Arnebia root oil promotes wound healing and expression of basic fibroblast growth factor on the wound surface in rabbits

Abstract

The promoting effect of arnebia root oils on wound healing may be related to increasing the expression level of basic fibroblast growth factor in the skin wound.

Water Extract of Gromwell <i>(Lithospermum erythrorhizon)</i> Enhances Migration of Human Keratinocytes and Dermal Fibroblasts with Increased Lipid Synthesis in an in vitro Wound Scratch Model

“…As for the bioactive components, naphthoquinones such as shikon and its derivatives have been characterized mostly in the organic extracts of gromwell, which has been shown to have wound healing effects [2][3][4][5][6][7] . Moreover, prior studies also demonstrated that naphthoquinones from gromwell not only increased the expression of vascular endothelial growth factor [5,6] , transforming growth factor-␤ 1 [22] and fibroblast growth factor 1 [23] , but also blocked the mRNA splicing of tumor necrosis factor-␣ [24] and inhibited biosynthesis of lipoxygenase and cyclooxygenase metabolites [25,26] . However, little is known about the biological activities of WG, which is more commonly used in traditional remedies than the organic extracts, which is why it has been the focus of the present studies.…”

Τεχνολογία Δευτερογενών Μεταβολιτών

“…Αμείωτο παραμένει ως και σήμερα το ενδιαφέρον της επιστημονικής κοινότητας όσον αφορά την εύρεση νέων φυτών της οικογένειας Boraginaceae, πλούσιων σε παράγωγα αλκαννίνης και σικονίνης. Το γεγονός αυτό αποδεικνύεται από τον μεγάλο αριθμό των δημοσιευμένων εργασιών, μιας και η επουλωτική δράση των δραστικών συστατικών τους είναι πλέον αποδεδειγμένη (Huang et al, 2004;Mani et al, 2004;Ogurtan et al, 2002;Ozgen et al, 2006;Pei et al, 2006b;Pei et al, 2006a).…”