Aromatase inhibitors isolated from a flowering tea, snow Chrysanthemum (the capitula of Coreopsis tinctoria Nutt.)

Luo, Fenglin; Manse, Yoshiaki; Ishikawa, Satoshi; Nishi, Sakura; Chen, Anshin; Wang, Tao; Morikawa, Toshio

doi:10.1007/s11418-022-01678-3

Cited by 7 publications

(3 citation statements)

References 64 publications

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“…In our previous studies, each active fraction (the EtOAc-soluble and methanol-eluted fractions) was subjected to normalphase silica gel and reversed-phase ODS column chromatography, and finally to HPLC to obtain a total of 46 compounds including iridoid glycosides (1-7), phenylethanoid glycosides (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18), and aromatics (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29), etc., as shown in Fig. 1.…”

Section: Resultsmentioning

confidence: 99%

“…2,3) An extract of the rhizomes of P. kurroa, commonly known as "kutki," has been used for the treatment of liver and lung diseases, fever, skin lesions, worm infections, rheumatic diseases, urinary disorders, heart failure, and snake and scorpion bites in the Ayurvedic and Unani systems of medicine. [4][5][6][7] During characterization of the bioactive constituents of plants in Tibet and Xinjiang, both autonomous regions in China, [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] we had previously isolated 46 compounds including iridoid glycosides (1-7), phenylethanoid glycosides (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18), aromatics (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29), etc., from the rhizomes of P. kurroa using normal phase silica gel column chromatography followed by HPLC; these isolates exhibited hyaluronidase and collagenase inhibitory activities.…”

Section: Introductionmentioning

confidence: 99%

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Hepatoprotective Principles from the Rhizomes of <i>Picrorhiza kurroa</i>

Sakamoto

Inoue

Nakanishi

et al. 2023

Biological & Pharmaceutical Bulletin

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A methanol extract of rhizomes of Picrorhiza kurroa Royle ex Benth. (Plantaginaceae) showed hepatoprotective effects against D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced liver injury in mice. We had previously isolated 46 compounds, including several types of iridoid glycosides, phenylethanoid glycosides, and aromatics, etc., from the extract. Among them, picroside II, androsin, and 4-hydroxy-3-methoxyacetophenone exhibited active hepatoprotective effects at doses of 50-100 mg/kg, per os (p.o.) To characterize the mechanisms of action of these isolates and to clarify the structural requirements of phenylethanoid glycosides for their hepatoprotective effects, their effects were assessed in in vitro studies on (i) D-GalN-induced cytotoxicity in mouse primary hepatocytes, (ii) LPS-induced nitric oxide (NO) production in mouse peritoneal macrophages, and (iii) tumor necrosis factor-α (TNF-α)-induced cytotoxicity in L929 cells. These isolates decreased the cytotoxicity caused by D-GalN without inhibiting LPS-induced macrophage activation and also reduced the sensitivity of hepatocytes to TNF-α. In addition, the structural requirements of phenylethanoids for the protective effects of D-GalN-induced cytotoxicity in mouse primary hepatocytes were evaluated.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Principles from the Rhizomes of <i>Picrorhiza kurroa</i>

Sakamoto

Inoue

Nakanishi

et al. 2023

Biological & Pharmaceutical Bulletin

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“…The serum insulin levels of HFD mice were significantly increased after the administration of CT extract, suggesting that CT extract can prevent the development of type 2 diabetes in obese individuals. Literature has confirmed that CT regulates insulin production by improving pancreatic inflammation and reducing damage in obese individuals [ 13 , 46 , 47 ]. Under a high-fat diet, the body takes in excess energy, which leads to a physiological imbalance in energy consumption [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Coreopsis tinctoria improves energy metabolism in obese hyperglycemic mice

Huangfu,

Yang,

et al. 2024

Heliyon

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An Updated Review on Nelumbo Nucifera Gaertn: Chemical Composition, Nutritional Value and Pharmacological Activities

Sahu,

Sahu

et al. 2024

Chemistry & Biodiversity

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Nelumbo nucifera Gaertn is a recognised herbal plant in ancient medical sciences. Each portion of the plant leaf, flower, seed and rhizome is utilised for nutritional and medicinal purposes. The chemical compositions like phenol, alkaloids, glycoside, terpenoids and steroids have been isolated. The plant contains various nutritional values like lipids, proteins, amino acids, minerals, carbohydrates, and fatty acids. Traditional medicine confirms that the phytochemicals of plants give significant benefits to the treatment of various diseases such as leukoderma, smallpox, dysentery, haematemesis, coughing, haemorrhage, metrorrhagia, haematuria, fever, hyperlipidaemia, cholera, hepatopathy and hyperdipsia. To verify the traditional claims, researchers have conducted scientific biological in vivo and in vitro screenings, which have exhibited that the plant keeps various notable pharmacological activities such as anticancer, hepatoprotective, antioxidant, antiviral, hypolipidemic, anti‐obesity, antipyretic, hypoglycaemic, antifungal, anti‐inflammatory and antibacterial activities. This review, summaries the nutritional composition, chemical constituents and biological activities substantiated by the researchers done in vivo and in vitro.

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Aromatase inhibitors isolated from a flowering tea, snow Chrysanthemum (the capitula of Coreopsis tinctoria Nutt.)

Cited by 7 publications

References 64 publications

Hepatoprotective Principles from the Rhizomes of <i>Picrorhiza kurroa</i>

Hepatoprotective Principles from the Rhizomes of <i>Picrorhiza kurroa</i>

Coreopsis tinctoria improves energy metabolism in obese hyperglycemic mice

An Updated Review on Nelumbo Nucifera Gaertn: Chemical Composition, Nutritional Value and Pharmacological Activities

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