Aromatic Compound Catabolism in Corynebacterium glutamicum

The fermentation production of platform chemicals in biorefineries is a sustainable alternative to the current petroleum refining process. The natural advantages of Corynebacterium glutamicum in carbon metabolism have led to C. glutamicum being used as a microbial cell factory that can use various biomass to produce value-added platform chemicals and polymers. In this review, we discussed the use of C. glutamicum surface display engineering bacteria in the three generations of biorefinery resources, and analyzed the C. glutamicum engineering display system in degradation, transport, and metabolic network reconstruction models. These engineering modifications show that the C. glutamicum engineering display system has great potential to become a cell refining factory based on sustainable biomass, and further optimizes the inherent properties of C. glutamicum as a whole-cell biocatalyst. This review will also provide a reference for the direction of future engineering transformation.

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Promising non-model microbial cell factories obtained by genome reduction

Ravagnan,

Schmid

2024

Front. Bioeng. Biotechnol.

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The development of sustainable processes is the most important basis to realize the shift from the fossil-fuel based industry to bio-based production. Non-model microbes represent a great resource due to their advantageous traits and unique repertoire of bioproducts. However, most of these microbes require modifications to improve their growth and production capacities as well as robustness in terms of genetic stability. For this, genome reduction is a valuable and powerful approach to meet industry requirements and to design highly efficient production strains. Here, we provide an overview of various genome reduction approaches in prokaryotic microorganisms, with a focus on non-model organisms, and highlight the example of a successful genome-reduced model organism chassis. Furthermore, we discuss the advances and challenges of promising non-model microbial chassis.

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Aromatic Compound Catabolism in Corynebacterium glutamicum

Cited by 3 publications

References 48 publications

Bacterial enzymatic degradation of recalcitrant organic pollutants: catabolic pathways and genetic regulations

Bacterial enzymatic degradation of recalcitrant organic pollutants: catabolic pathways and genetic regulations

Application of Corynebacterium glutamicum engineering display system in three generations of biorefinery

Promising non-model microbial cell factories obtained by genome reduction

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