Aromatic Hydroxylation in Nasal Lavage Fluid Following Ambient Ozone Exposure

Frischer, T.; Pullwitt, A.; Kühr, J.; Meinert, Rolf; Haschke, N.; Studnicka, Michael; Lubec, Gert

doi:10.1016/s0891-5849(96)00292-4

Cited by 27 publications

(11 citation statements)

References 28 publications

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“…There are studies concerning measurement of nasal inflammatory markers showing that it can generally be assumed to reflect lower airway pathology [5,[11][12][13][14][15]. Jyonouchi et al [5], have evaluated distribution of IgG antibodies in the airway in association with inflammatory changes in a rabbit sinusitis model.…”

Section: Discussionmentioning

confidence: 99%

“…The response of the lower airway to the exposure of the upper airway to allergens, viral infection, and to different exogenous harmful substances, such as Masses of PMN cells infiltrating the entire wall down to and including the adventitia; the epithelium is disrupted; at least 50% of the airway circumference involved ozone, passive smoking, or particles have been studied. In exposure studies with ozone [14] or swine dust in adults [15], changes in nasal lavage samples reflect, to some extent, inflammation in the lower airway. In experimentally induced infection with rhinovirus, it has been shown that the virus can be found both in the upper and lower airway [12].…”

Section: Discussionmentioning

confidence: 99%

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Analysis of Lower Airway Inflammation in a Rabbit Model of Acute Rhinosinusitis

Selçuk¹,

Akdoğan

Giray

et al. 2011

Indian J Otolaryngol Head Neck Surg

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This study aimed to investigate the association of inflammatory changes of upper and lower airways in a rabbit model of acute rhinosinusitis. The study included six adult albino rabbits. The sinuses of one animal were injected with saline solution and the animal was served as sham control. Other animals were implanted with intranasal S. aureus soaked-absorbable gelatin sponge. Acute rhinosinusitis was induced and subjects were sacrificed at the end of the second week. Tissue samples from all levels of the airway were obtained. They were evaluated for the presence of inflammatory changes histologically. A scoring system for airway inflammation was used for quantitative assessment of the degree of inflammation. Structural changes in the epithelial and stromal layers of the upper and lower airway structures were analyzed, as well. The animal of which the sinuses were injected with saline solution developed neither acute rhinosinusitis nor lower airway inflammation. In contrast, the animals in which acute rhinosinusitis was induced demonstrated significant upper and lower airway inflammation histologically. Inflammatory changes ranged from engorgement of blood vessels and polymorphonuclear cell proliferation within the capillaries, in the perivascular tissue of the epithelium or in the lamina propria and to epithelial disruption. Nasal airway inflammation scores (2.86 ± 1.81) were significantly higher than lower airway scores (1.36 ± 0.77), (P \ 0.01). We obtained a generalized mucosal inflammatory response against localized bacterial inflammation in a rabbit model of acute rhinosinusitis, confirming the suggestion of 'one airway--one disease' from a bacterial infection point of view.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Analysis of Lower Airway Inflammation in a Rabbit Model of Acute Rhinosinusitis

Selçuk¹,

Akdoğan

Giray

et al. 2011

Indian J Otolaryngol Head Neck Surg

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“…Es sind dies vor allem Zeitreihen-Untersuchungen (Friza et al, 1986;Neuberger et al, 1987Neuberger et al, , 2004Neuberger et al, , 2005Neuberger et al, , 2007aNeuberger et al, , 2007bNeuberger et al, , 2008Krüger et al, 2009), aber auch Längsschnitt-Untersuchungen (Neuberger et al, , 2002 und PanelUntersuchungen (Wittels et al, 1997;Moshammer et al, 2006a;Moshammer und Neuberger, 2003;Ihorst et al, 2004;Horak et al, 2002;Frischer et al, 1997Frischer et al, , 1999Frischer et al, , 2001Kopp et al, 2000) sowie Querschnittsstudien (Pattenden et al, 2006 …”

Section: Luftqualität: Dosis-wirkungs-beziehungunclassified

Kapitel 4: Gesundheit, Tourismus

Moshammer¹,

Prettenthaler²,

Damm³

et al. 2014

Österreichischer Sachstandsbericht Klimawandel 2014

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“…Acute effects of ozone on pulmonary function and airway inflammation have been observed in controlled human exposure (McDonnell et al, 1995;Koren et al, 1990Koren et al, , 1991Balmes et al, 1997;Devlin et al, 1997;Frampton et al, 1997aFrampton et al, , 1997b and field studies (Kinney et al, 1989;Spektor et al, 1991;Frischer et al, 1993Frischer et al, , 1997. In order to determine risks associated with population exposure to ozone, it is essential to have an accurate estimate of ozone concentrations that can cause human health effects using relatively noninvasive methods.…”

mentioning

confidence: 99%

“…A short-term exposure of human subjects to 0.12 to 0.4 ppm ozone has been found to cause nasal inflammatory responses, including increases in nasal polymorphonuclear neutrophils McBride et al, 1994) and albumin levels . Epidemiological field studies have demonstrated an association between ozone concentrations in ambient air and increased inflammatory responses (Frischer et al, 1993) and free radical production (Frischer et al, 1997) in nasal lavage fluid of school children. Induced sputum is composed of fluid and cellular components originating mostly from the bronchial regions (Fahy et al, 1993(Fahy et al, , 1995a.…”

mentioning

confidence: 99%

A Comparison of Biomarkers of Ozone Exposure in Human Plasma, Nasal Lavage, and Sputum

Liu

Leech

Urch

et al. 1999

Inhalation Toxicology

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We examined ozone-induced upper and lower airway inflammatory responses and the concentrations of hydroxylated salicylate metabolites using nasal lavage fluid and induced sputum, in order to identify noninvasive and sensitive biomarkers for ozone exposure and effects. A time course for plasma concentration of 2, 3-dihydroxybenzoic acid (2,3-DHBA, a salicylate metabolite and an indicator for hydroxyl radical) in response to 0.12 ppm ozone was also studied. Healthy, young, nonsmoking volunteers were given acetylsalicylic acid (ASA, 975 mg) or placebo orally. Subjects were exposed to ozone (0.12 or 0.4 ppm) or filtered air in an environmental chamber for 2 h, while performing intermittent exercise. Blood was collected hourly over a 4-h period. After exposure, nasal lavage fluid was collected, and sputum was induced using hypertonic saline. Results show that in sputum the percentage of neutrophils was significantly higher after the subjects were exposed to 0.4 ppm ozone (p<.05) than after they were exposed to filtered air or 0.12 ppm ozone. The absolute number and the percentage of macrophages were significantly lower at 0.4 ppm ozone than for filtered air control or 0.12 ppm ozone. The percentage of lymphocytes in sputum was also significantly lower at 0.4 ppm ozone than for filtered air control or 0.12 ppm ozone. The sputum cellular responses to ozone were not significantly altered by ASA treatment. In nasal lavage, cell counts and differentials did not change significantly after exposure to ozone in comparison to filtered air control. The cellular data indicate an acute inflammation developed during ozone exposure in the lower respiratory tract. The concentrations of total protein and interleukin-8 and the activity of N-acetyl-beta-D-glucosaminidase (a lysosomal enzyme) in nasal lavage and sputum did not change significantly following exposure to ozone in comparison to filtered air control. Plasma 2,3-DHBA concentration increased significantly following exposure to 0.12 ppm ozone in an exposure-dependent temporal pattern. Salicylate metabolites in nasal lavage fluid and sputum did not increase significantly following exposure to ozone. There was a marked variation of 2,3-DHBA concentrations in airway fluids. Data suggest that plasma 2,3-DHBA is a sensitive marker indicating acute ozone exposure, even at an ozone concentration that causes minimal observable airway effects in healthy subjects.

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Aromatic Hydroxylation in Nasal Lavage Fluid Following Ambient Ozone Exposure

Cited by 27 publications

References 28 publications

Analysis of Lower Airway Inflammation in a Rabbit Model of Acute Rhinosinusitis

Analysis of Lower Airway Inflammation in a Rabbit Model of Acute Rhinosinusitis

Kapitel 4: Gesundheit, Tourismus

A Comparison of Biomarkers of Ozone Exposure in Human Plasma, Nasal Lavage, and Sputum

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