Aromaticity Tuning of Heavy-Atom-Free Photosensitizers for Singlet Fission-Enhanced Immunogenic Photodynamic Oncotherapy

Chen, Dapeng; Shao, Jinjun; Zhang, Tian; Xu, Kang; Liang, Chen; Cai, Yu; Guo, Yuxin; Chen, Peng; Mou, Xiao-Zhou; Dong, Xiaochen

doi:10.1021/acs.nanolett.4c01862

Nano Lett.

2024

DOI: 10.1021/acs.nanolett.4c01862

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Aromaticity Tuning of Heavy-Atom-Free Photosensitizers for Singlet Fission-Enhanced Immunogenic Photodynamic Oncotherapy

Dapeng Chen,

Jinjun Shao,

Tian Zhang

et al.

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Cited by 3 publications

References 38 publications

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Molecular endoperoxides for optical imaging and photodynamic therapy

Chen,

Zhang,

Jiao

et al. 2025

Coordination Chemistry Reviews

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Molecular endoperoxides for optical imaging and photodynamic therapy

Chen,

Zhang,

Jiao

et al. 2025

Coordination Chemistry Reviews

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Synthesis of heavy-atom-free thienoisoindigo dye as near-infrared photosensitizer for type I photodynamic therapy and photoacoustic imaging

Zhang,

Cai,

Wang

et al. 2024

Journal of Photochemistry and Photobiology B: Biology

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Coassembly of Dual-Modulated AIE-ESIPT Photosensitizers and UCNPs for Enhanced NIR-Excited Photodynamic Therapy

Hu,

Li,

Feng

et al. 2024

Nano Lett.

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Aggregation-induced emission (AIE) photosensitizers are promising for photodynamic therapy, yet their short excitation wavelengths present a limitation. In this study, we develop a series of organic photosensitizers with dual modulation capabilities based on excited-state intramolecular proton transfer (ESIPT) and AIE. Notably, we synthesize near-infrared (NIR)excited photosensitive nanoparticles through a coassembly strategy utilizing upconversion nanoparticles (UCNPs) and amphiphilic polymers. The spectroscopic analysis and theoretical calculations elucidate the significant impact of additional or π-spacer groups on the conformational change and the energy barrier of the ESIPT process. An efficient Forster resonance energy transfer between the photosensitizer and UCNPs is achieved through the coassembly strategy. Both in vitro and in vivo experiments demonstrate the antitumor efficacy of these nanoparticles under NIR excitation. This work not only introduces a novel approach for simultaneously modulating AIE properties and the ESIPT process but also provides a robust solution for overcoming the excitation wavelength limitations of many organic photosensitizers.

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Aromaticity Tuning of Heavy-Atom-Free Photosensitizers for Singlet Fission-Enhanced Immunogenic Photodynamic Oncotherapy

Cited by 3 publications

References 38 publications

Molecular endoperoxides for optical imaging and photodynamic therapy

Molecular endoperoxides for optical imaging and photodynamic therapy

Synthesis of heavy-atom-free thienoisoindigo dye as near-infrared photosensitizer for type I photodynamic therapy and photoacoustic imaging

Coassembly of Dual-Modulated AIE-ESIPT Photosensitizers and UCNPs for Enhanced NIR-Excited Photodynamic Therapy

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