AROS-29 is involved in adaptive response to oxidative stress

Gesualdi, Nicola Montesano; Chirico, Giuseppa; Catanese, Maria Teresa; Pirozzi, Giuseppe; Esposito, Franca

doi:10.1080/10715760600570547

Cited by 18 publications

(10 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reactive oxygen species including hydrogen peroxide, superoxide anion, and singlet oxygen are generated as by-products of cellular metabolism primarily in mitochondria, and play a predominant role in many pathological conditions, including immune suppression, photo-carcinogenesis, and photo-aging [ 1 – 4 ]. Excessive generation of reactive oxygen species in the skin is a major contributor for various cutaneous pathologies [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Naringenin-Loaded Elastic Liposomes for Topical Application

et al. 2015

View full text Add to dashboard Cite

Excessive production of radical oxygen species in skin is a contributor to a variety of skin pathologies. Naringenin is a potent antioxidant. The purpose of the present study was to develop elastic liposomes for naringenin topical application. Naringenin-loaded elastic liposomes containing different amounts of Tween 80 and cholesterol were prepared. The physicochemical properties including vesicle size, surface charge, encapsulation efficiency, and permeability capacity were determined to evaluate the effect of components. The stability of formulation and skin irritation caused by drug-loaded elastic liposomes were also evaluated for assessment of the clinical utility of elastic liposomes. Saturated aqueous solution of naringenin and naringenin dissolved in 10% Tween 80 solution (5 mg/mL) were used as the control group. The result showed that in using elastic liposomes as carrier, the deposition amounts in the skin of naringenin were significantly increased about 7.3~11.8-fold and 1.2~1.9-fold respectively, when compared with the saturated aqueous solution and Tween 80 solution-treated groups. The level of drug was more than 98.89±3.90% after 3 months of storage at 4℃. In a skin irritation test, the result showed experimental formulation exhibit considerably less irritating than the positive control (paraformaldehyde-treated) group, suggesting its potential therapeutic application.

show abstract

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Naringenin-Loaded Elastic Liposomes for Topical Application

et al. 2015

View full text Add to dashboard Cite

show abstract

“…When their production exceeds the cell's antioxidant capacity, macromolecules such as lipids, proteins, and DNA can be damaged. 1 Excessive generation of ROS in the skin is believed to be an important contributor to a variety of cutaneous pathologies, including different types of cancers. 2,3 ROS such as superoxide anion, hydrogen peroxide, and singlet oxygen, also play a critical role in many pathological conditions, including immune suppression, photo-aging, and photocarcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

Resveratrol-loaded solid lipid nanoparticles versus nanostructured lipid carriers: evaluation of antioxidant potential for dermal applications

Gökçe¹,

Korkmaz²,

Dellera³

et al. 2012

IJN

279

130

View full text Add to dashboard Cite

Background: Excessive generation of radical oxygen species (ROS) is a contributor to skin pathologies. Resveratrol (RSV) is a potent antioxidant. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) can ensure close contact and increase the amount of drug absorbed into the skin. In this study, RSV was loaded into SLN and NLC for dermal applications. Methods: Nanoparticles were prepared by high shear homogenization using Compritol 888ATO, Myglyol, Poloxamer188, and Tween80. Particle size (PS), polydispersity index (PI), zeta potential (ZP), drug entrapment efficiency (EE), and production yield were determined. Differential scanning calorimetry (DSC) analysis and morphological transmission electron microscopy (TEM) examination were conducted. RSV concentration was optimized with cytotoxicity studies, and net intracellular accumulation of ROS was monitored with cytofluorimetry. The amount of RSV was determined from different layers of rat abdominal skin. Results: PS of uniform RSV-SLN and RSV-NLC were determined as 287.2 nm ± 5.1 and 110.5 nm ± 1.3, respectively. ZP was −15.3 mV ± 0.4 and −13.8 mV ± 0.1 in the same order. The drug EE was 18% higher in NLC systems. TEM studies showed that the drug in the shell model was relevant for SLN, and that the melting point of the lipid in NLC was slightly lower. Concentrations below 50 µM were determined as suitable RSV concentrations for both SLN and NLC in cell culture studies. RSV-NLC showed less fluorescence, indicating less ROS production in cytofluorometric studies. Ex vivo skin studies revealed that NLC are more efficient in carrying RSV to the epidermis. Conclusion: This study suggests that both of the lipid nanoparticles had antioxidant properties at a concentration of 50 µM. When the two systems were compared, NLC penetrated deeper into the skin. RSV-loaded NLC with smaller PS and higher drug loading appears to be superior to SLN for dermal applications.

show abstract

“…Notably, four SNPs located within TMEM161A were grouped into a haplotype block, and association analysis confirmed that both the SNPs and the haplotype were significantly associated with EN48 and EN60. TMEM161A, also known as adaptive response to oxidative stress protein 29 (AROS-29), is involved in several cellular processes, including the adaptive response to oxidative stress (Montesano Gesualdi et al, 2006), the response to ultraviolet radiation, and the response to retinoic acid; in addition, TMEM161A is a negative regulator of the intrinsic apoptotic signaling pathway in response to DNA damage and is a positive regulator of the DNA repair response. In birds, retinoic acid promotes embryonic development and egg production and can regulate the number of eggs (Fu et al, 2000;Scheider et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Genome-Wide Association Study-Based Identification of SNPs and Haplotypes Associated With Goose Reproductive Performance and Egg Quality

Gao

Zhao

et al. 2021

Front. Genet.

View full text Add to dashboard Cite

Geese are one of the most economically important waterfowl. However, the low reproductive performance and egg quality of geese hinder the development of the goose industry. The identification and application of genetic markers may improve the accuracy of beneficial trait selection. To identify the genetic markers associated with goose reproductive performance and egg quality traits, we performed a genome-wide association study (GWAS) for body weight at birth (BBW), the number of eggs at 48 weeks of age (EN48), the number of eggs at 60 weeks of age (EN60) and egg yolk color (EYC). The GWAS acquired 2.896 Tb of raw sequencing data with an average depth of 12.44× and identified 9,279,339 SNPs. The results of GWAS showed that 26 SNPs were significantly associated with BBW, EN48, EN60, and EYC. Moreover, five of these SNPs significantly associated with EN48 and EN60 were in a haplotype block on chromosome 35 from 4,512,855 to 4,541,709 bp, oriented to TMEM161A and another five SNPs significantly correlated to EYC were constructed in haplotype block on chromosome 5 from 21,069,009 to 21,363,580, which annotated by TMEM161A, CALCR, TFPI2, and GLP1R. Those genes were enriched in epidermal growth factor-activated receptor activity, regulation of epidermal growth factor receptor signaling pathway. The SNPs, haplotype markers, and candidate genes identified in this study can be used to improve the accuracy of marker-assisted selection for the reproductive performance and egg quality traits of geese. In addition, the candidate genes significantly associated with these traits may provide a foundation for better understanding the mechanisms underlying reproduction and egg quality in geese.

show abstract

AROS-29 is involved in adaptive response to oxidative stress

Cited by 18 publications

References 37 publications

Preparation and Characterization of Naringenin-Loaded Elastic Liposomes for Topical Application

Preparation and Characterization of Naringenin-Loaded Elastic Liposomes for Topical Application

Resveratrol-loaded solid lipid nanoparticles versus nanostructured lipid carriers: evaluation of antioxidant potential for dermal applications

Genome-Wide Association Study-Based Identification of SNPs and Haplotypes Associated With Goose Reproductive Performance and Egg Quality

Contact Info

Product

Resources

About