2023
DOI: 10.1101/2023.11.06.565918
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Arousal as a universal embedding for spatiotemporal brain dynamics

Ryan V. Raut,
Zachary P. Rosenthal,
Xiaodan Wang
et al.

Abstract: Neural activity in awake organisms shows widespread and spatiotemporally diverse correlations with behavioral and physiological measurements. We propose that this covariation reflects in part the dynamics of a unified, arousal-related process that regulates brain-wide physiology on the timescale of seconds. This interpretation motivates a surprising prediction: that a single, scalar measurement of arousal (e.g., pupil diameter) should suffice to reconstruct the evolution of multimodal, spatiotemporal measureme… Show more

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Cited by 3 publications
(2 citation statements)
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“…Covariation with multiple autonomic signals suggests that global brain fluctuations measured with fMRI/EEG may form one component of a larger, integrated physiological network spanning multiple organ systems governed by the ANS. Previous studies provide support for this hypothesis, showing that global hemodynamic and EEG power fluctuations covary closely in time with peripheral physiological recordings from the respiratory system, cardiovascular and peripheral vasculature (Gu et al, 2022), and may reflect spontaneous fluctuations in arousal (Raut et al, 2021, 2023).…”
Section: Introductionmentioning
confidence: 83%
“…Covariation with multiple autonomic signals suggests that global brain fluctuations measured with fMRI/EEG may form one component of a larger, integrated physiological network spanning multiple organ systems governed by the ANS. Previous studies provide support for this hypothesis, showing that global hemodynamic and EEG power fluctuations covary closely in time with peripheral physiological recordings from the respiratory system, cardiovascular and peripheral vasculature (Gu et al, 2022), and may reflect spontaneous fluctuations in arousal (Raut et al, 2021, 2023).…”
Section: Introductionmentioning
confidence: 83%
“…Cognitive and emotional behaviors are intimately linked with context-dependent modulation of physiological indicators of arousal 11,12 . Hence, prominent arousal modulation of cortical activity may represent a fundamental mechanism for coordinating central and bodily processes important for behavioral control 13,14 .…”
Section: Mainmentioning
confidence: 99%