This systematic review synthesizes findings from 19 studies on stressors and coping strategies in esports, following the PRISMA guidelines and employing the SPIDER framework. The review reports stressors in esports, with performance stressors such as defeat and performance pressure prominently observed, followed by team, organizational, and personal stressors. A diverse range of coping strategies were identified, representing Nicholls et al. (2016)’s classification. Internal regulation emerged as the most frequently reported coping strategy, followed by mastery coping, while goal withdrawal strategies were less frequently reported. The review reveals similarities and distinctions compared to traditional sports, highlighting the role of stressors such as social media and equipment challenges in esports. However, personal stressors were rarely reported in the studies. The review also identifies research gaps in stressor appraisal and communal coping strategies. Future research could delve into personal stressors, considering a wide array of psychological factors, and employing dynamic methodologies. Practical implications revolve around tailored interventions, promoting open communication, mastery coping techniques, and holistic well-being strategies. This review provides a broader understanding of esports stressors and coping strategies, offering a starting point for targeted interventions aimed at enhancing performance and well-being in the distinctive competitive landscape of esports.