Arrabidaea chica (Humb. &amp; Bonpl.) B. Verlot (Bignoniaceae)

Behrens, Maria Dutra; Tellis, Carla Junqueira Moragas; Chagas, Maria do Socorro dos Santos

doi:10.32712/2446-4775.2012.165

Cited by 10 publications

(4 citation statements)

References 23 publications

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“…The folioles have an oblong-lanceolate shape, cartaceous, with an obtuse base, acute apex and herbaceous consistency. The surface of the folioles is smooth, and the rib is of the peninerveal type, i.e., the secondary ribs branch from the main rib [ 3 , 7 , 8 , 9 ]. The flowers are campanulate, resemble the shape of a bell, and have pink or violet coloration [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Leaves from Fridericia chica (Bonpl.) L. G. Lohmann: Botanical Aspects, Phytochemical and Biological, Anti-Inflammatory, Antioxidant and Healing Action

et al. 2022

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Plants of the species Fridericia chica (Bonpl.) L. G. Lohmann (Bignoniaceae), which are widely distributed in Brazil and named crajiru in the state of Amazonas, are known in folk medicine as a traditional medicine in the form of a tea for the treatment of intestinal colic, diarrhea, and anemia, among other diseases. The chemical analysis of extracts of the leaves has identified phenolic compounds, a class of secondary metabolites that provide defense for plants and benefits to the health of humans. Several studies have shown the therapeutic efficacy of F. chica extracts, with antitumor, antiviral, wound healing, anti-inflammatory, and antioxidant activities being among the therapeutic applications already proven. The healing action of F. chica leaf extract has been demonstrated in several experimental models, and shows the ability to favor the proliferation of fibroblasts, which is essential for tissue repair. The anti-inflammatory activity of F. chica has been clearly demonstrated by several authors, who suggest that it is related to the presence of 3-deoxyanthocyanidins, which is capable of inhibiting pro-inflammatory pathways such as the kappa B (NF-kB) nuclear transcription factor pathway. Another important effect attributed to this species is the antioxidant effect, attributed to phenolic compounds interrupting chain reactions caused by free radicals and donating hydrogen atoms or electrons. In conclusion, the species Fridericia chica has great therapeutic potential, which is detailed in this paper with the objective of encouraging new research and promoting the sum of efforts for the inclusion of herbal medicines in health systems around the world.

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Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Leaves from Fridericia chica (Bonpl.) L. G. Lohmann: Botanical Aspects, Phytochemical and Biological, Anti-Inflammatory, Antioxidant and Healing Action

et al. 2022

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“…It comprises about 120 genera and 860 species (Fischer et al, 2004;Sampaio et al, 2016). A. chica occurs in tropical America, being a very common species in the Amazon region (Takemura et al, 1995;dos Santos et al, 2013) and is popularly known as crajiru or pariri (Behrens et al, 2012). It is traditionally used as a medicinal plant in the Amazon region (Takemura et al, 1995), with the use of tea made from leaves as an anti-inflammatory (Evangelista et al, 2013), to treat skin inflammation and mycoses (Corrêa, 1984), and has astringent properties (Lima de Medeiros et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Antileishmanial Activity of Flavones-Rich Fraction From Arrabidaea chica Verlot (Bignoniaceae)

et al. 2021

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Acknowledging the need of identifying new compounds for the treatment of leishmaniasis, this study aimed to evaluate, from in vitro trials, the activity of flavones from Arrabidaea chica against L. amazonensis. The chromatographic profiles of the hydroethanolic extract and a flavone-rich fraction (ACFF) from A. chica were determined by high-performance liquid chromatography coupled with a diode-array UV-Vis detector (HPLC-DAD-UV) and electrospray ionization mass spectrometry in tandem (LC-ESI-MS-MS). The flavones luteolin (1) and apigenin (2), isolated from chromatographic techniques and identified by Nuclear Magnetic Resonance of 1H and 13C, were also quantified in ACFF, showing 190.7 mg/g and apigenin 12.4 mg/g, respectively. The other flavones were identified by comparing their spectroscopic data with those of the literature. The in vitro activity was assayed against promastigotes and intramacrophagic amastigote forms of L. amazonensis. Cytotoxicity tests were performed with peritoneal macrophages of BALB/c mice. Nitrite quantification was performed with Griess reagent. Ultrastructural investigations were obtained by transmission electron microscopy. Anti-Leishmania assays indicated that the IC50 values for ACFF, apigenin, and luteolin were obtained at 40.42 ± 0.10 and 31.51 ± 1.13 μg/mL against promastigotes, respectively. ACFF and luteolin have concentration-dependent cytotoxicity. ACFF and luteolin also inhibited the intra-macrophagic parasite (IC50 3.575 ± 1.13 and 11.78 ± 1.24 μg/mL, respectively), with a selectivity index of 11.44 for ACFF. Promastigotes exposed to ACFF and luteolin exhibited ultrastructural changes, such as intense cytoplasm vacuolization and mitochondrial swelling. These findings data evidence the antileishmanial action of flavone-rich fractions of A. chica against L. amazonensis, encouraging further studies.

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“…Lohmann, which became the official name of the species) belongs to the Bignoniaceae family, which comprises of about 100 genera and 860 species [1]. This species is popularly known as crajiru, pariri and cipó cruz among other other names [2][3][4]. The plant is listed as a natural dye, its leaves being used traditionally by indigenous peoples as a body paint [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…), with large leaves (up to 10 cm long and 6 cm wide), a larger panicle and a 3 cm corolla [7]. Little is recorded of the phytochemical variation that may accompany these varieties or of the relation between their metabolites and their biological activity [2].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Anthocyanidin Profile on Antileishmanial Activity of Arrabidaea chica Morphotypes

Tellis¹,

Almeida-Souza

Chagas³

et al. 2020

Molecules

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Arrabidaea chica Verlot (crajiru) is a plant used in folk medicine as an astringent, anti-inflammatory, wound healing and to treat fungal and viral diseases such as measles chickenpox and herpes. Arrabidaea chica has several morphotypes recognized but little is known about its chemical variability. In the present study the anthocyanidin profile of A. chica morphotypes collected in two seasons (summer and winter) have been examined and their activity against Leishmania infection compared. High-performance liquid chromatography coupled to a diode-array detector (HPLC-DAD-UV) and by tandem mass spectrometry with electrospray ionization (ESI-MS/MS) were used for anthocyanidin separation and identification. Antileishmanial activity was measured against promastigote forms of Leishmania amazonensis. Multivariate analysis, principal component analysis (PCA) and Pearson’s correlation were performed to classify morphotypes accordingly to their anthocyanidin profile. The presence of 6,7,3′,4′-tetrahydroxy-5-methoxyflavylium (3′-hydroxy-carajurone) (1), carajurone (2), 6,7,3′-trihydroxy-5,4′-dimethoxy-flavylium (3′-hydroxy-carajurin) (3) and carajurin (4), and three unidentified anthocyanidins were detected. Two different groups were recognized: group I containing 3′-hydroxy-carajurone; and group II with high content of carajurin. Among anthocyanidins identified in the extracts, only carajurin showed significant statistical correlation (p = 0.030) with activity against L. amazonensis. Carajurin could thus be considered as a pharmacological marker for the antileishmanial potential of the species.

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Arrabidaea chica (Humb. & Bonpl.) B. Verlot (Bignoniaceae)

Cited by 10 publications

References 23 publications

Therapeutic Potential of Leaves from Fridericia chica (Bonpl.) L. G. Lohmann: Botanical Aspects, Phytochemical and Biological, Anti-Inflammatory, Antioxidant and Healing Action

Therapeutic Potential of Leaves from Fridericia chica (Bonpl.) L. G. Lohmann: Botanical Aspects, Phytochemical and Biological, Anti-Inflammatory, Antioxidant and Healing Action

Antileishmanial Activity of Flavones-Rich Fraction From Arrabidaea chica Verlot (Bignoniaceae)

The Influence of Anthocyanidin Profile on Antileishmanial Activity of Arrabidaea chica Morphotypes

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