Array-on-a-disk? How Blu-ray technology can be applied to molecular diagnostics

Cellphone-based diagnostic devices

“…Most consumer electronic devices provide an easy route for researchers to develop new sensing applications using cellphones, scanners, and disc players on the basis of their powerful capabilities and accessibility [15][16][17][18][19][20][21][22][23]. Cellphones especially outweigh over others in terms of their convenience in myriad situations in mundane life.…”

Enzyme Inhibition Microassays on Blu-Ray Disks for Drug Discovery

“…16−21 We present a methodology that uses Blu-ray-based microarray technology (disks as assay platform and a disk-player as detector) to perform assays for drug screening of inhibitors against horseradish peroxidase (HRP) as a member of the glycoenzymes superfamily. 22 We establish the basis for the development of high-throughput screening assay using compact disk technology and develop a novel strategy based on kinetic and thermodynamic parameters for drug discovery, identifying hits during primary screening stages.…”

Polymorphism genotyping based on loop-mediated isothermal amplification and smartphone detection

“…In line with this, the features of consumer electronic devices are 82 excellent as they are ubiquitous, low-cost, compact and high-performance products that can 83 benefit advanced analytical measurements (Kido et al, 2000;Maquieira, 2012;Ozcan, 2014;84 Quesada-González et al, 2016). The sensing devices described for diagnostic purposes include compact disc drivers (Morais et al, 2014), flatbed scanners (Tortajada-Genaro et al, 2016) and mobile phones (Roda et al, 2016;Kanchi et al, 2018), among others. In this study, we explored the colorimetric detection of the developed homogeneous and heterogeneous LAMP assays supported by smartphone technology due to its widespread presence, portability and capacity to transmit data at a user-friendly interface.…”