Arrhythmia insensitive rapid cardiac T1 mapping pulse sequence

Fitts, Michelle; Breton, Élodie; Kholmovski, Eugene; Dosdall, Derek J.; Vijayakumar, Sathya; Hong, Kyung Pyo; Ranjan, Ravi; Marrouche, Nassir F.; Axel, Leon; Kim, Daniel

doi:10.1186/1532-429x-15-s1-o112

Cited by 33 publications

(76 citation statements)

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“…For T 2 , the mean myocardial value measured with MRF was 38ms (min 34ms, max 43ms), which is consistent with the mean value obtained with the T 2 -prepared bSSFP sequence of 38ms (min 32ms, max 43ms). These measurements lie within the range of previously reported native myocardial relaxation times at 3T of T 1 from 1080-1500ms (16,18,24,38) and T 2 from 38-50ms (24,39). The mean M 0 measured in myocardium was 0.28 but exhibited wide variability across subjects (min 0.12, max 0.39).…”

Section: Human Volunteer Imagingsupporting

confidence: 85%

MR fingerprinting for rapid quantification of myocardial T₁ , T₂ , and proton spin density

et al. 2017

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Purpose-To introduce a 2D MR Fingerprinting technique for quantification of T 1 , T 2 , and M 0 in myocardium.Methods-An ECG-triggered MR Fingerprinting (MRF) method is introduced for mapping myocardial T 1 , T 2 , and M 0 during a single breathhold in as short as four heartbeats. The pulse sequence employs variable flip angles, repetition times, inversion recovery times, and T 2 preparation dephasing times. A dictionary of possible signal evolutions is simulated for each scan that incorporates the subject's unique variations in heart rate. Aspects of the sequence design were explored in simulations, and the accuracy and precision of cardiac MRF were assessed in a phantom study. In vivo imaging was performed at 3T in eleven volunteers to generate native parametric maps.Results-T 1 and T 2 measurements from the proposed cardiac MRF sequence correlated well with standard spin echo measurements in the phantom study (R 2 >0.99). A Bland-Altman analysis revealed good agreement for myocardial T 1 measurements between MRF and MOLLI (bias 1ms, 95% limits of agreement −72 to 72ms) and T 2 measurements between MRF and T 2 -prepared bSSFP (bias −2.6ms, 95% limits of agreement −8.5 to 3.3ms). Conclusions-MRFcan provide quantitative single slice T 1 , T 2 , and M 0 maps in the heart within a single breathhold.

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Section: Human Volunteer Imagingsupporting

confidence: 85%

MR fingerprinting for rapid quantification of myocardial T₁ , T₂ , and proton spin density

et al. 2017

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“…Several T1 mapping techniques have been proposed by using different acquisition schemes to sample the T1 recovery signal (1,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Multiple images with different T1-weighting are generally acquired and used to provide quantitative T1 estimates by using a model of the T1 recovery signal (1,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20).…”

Section: Methodsmentioning

confidence: 99%

“…Multiple images with different T1-weighting are generally acquired and used to provide quantitative T1 estimates by using a model of the T1 recovery signal (1,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Despite the promise of these T1 mapping techniques to improve diagnosis, prognosis, and monitoring response to therapy in a variety of Implications for Patient Care n SAPPHIRE and SASHA can be used for accurate myocardial T1 assessment.…”

Section: Methodsmentioning

confidence: 99%

Accuracy, Precision, and Reproducibility of Four T1 Mapping Sequences: A Head-to-Head Comparison of MOLLI, ShMOLLI, SASHA, and SAPPHIRE

et al. 2014

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To compare accuracy, precision, and reproducibility of four commonly used myocardial T1 mapping sequences: modified Look-Locker inversion recovery (MOLLI), shortened MOLLI (ShMOLLI), saturation recovery single-shot acquisition (SASHA), and saturation pulse prepared heart rate independent inversion recovery (SAPPHIRE). Materials andMethods:This HIPAA-compliant study was approved by the institutional review board. All subjects provided written informed consent. Accuracy, precision, and reproducibility of the four T1 mapping sequences were first compared in phantom experiments. In vivo analysis was performed in seven healthy subjects (mean age 6 standard deviation, 38 years 6 19; four men, three women) who were imaged twice on two separate days. In vivo reproducibility of native T1 mapping and extracellular volume (ECV) were measured. Differences between the sequences were assessed by using Kruskal-Wallis and Wilcoxon rank sum tests (phantom data) and mixed-effect models (in vivo data). Results:T1 mapping accuracy in phantoms was lower with ShMOLLI (62 msec) and MOLLI (44 msec) than with SASHA (13 msec; P , .05) and SAPPHIRE (12 msec; P , .05). MOLLI had similar precision to ShMOLLI (4.0 msec vs 5.6 msec; P = .07) but higher precision than SAPPHIRE (6.8 msec; P = .002) and SASHA (8.7 msec; P , .001). All sequences had similar reproducibility in phantoms (P = .1). The four sequences had similar in vivo reproducibility for native T1 mapping (~25-50 msec; P . .05) and ECV quantification (~0.01-0.02; P . .05). Conclusion:SASHA and SAPPHIRE yield higher accuracy, lower precision, and similar reproducibility compared with MOLLI and ShMOLLI for T1 measurement. Different sequences yield different ECV values; however, all sequences have similar reproducibility for ECV quantification.q RSNA, 2014

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“…Many sessions discussed the current use of T1 maps and the need to standardize and optimize the acquisition techniques to pre- and post-contrast maps, the use of bolus versus continuous infusion of gadolinium as well as the different approaches to heart rate variability and types of sequences. Fitts et al presented a recent arrhythmia-insensitive rapid T1 mapping sequence to overcome some of the limitations of the most widely used modified Look-Locker inversion recovery (MOLLI) techniques [28]. The sequence is based on saturation recovery magnetization and uses centric k-space ordering resulting in smaller coefficients of variation and higher T1 values in patients with high heart rates or arrhythmias.…”

Section: Technical Advances/imaging Methodsmentioning

confidence: 99%

Highlights of the 16th annual scientific sessions of the Society for Cardiovascular Magnetic Resonance

Carpenter

Patel

Fernandes

2013

Journal of Cardiovascular Magnetic Resonance

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The 16th Annual Scientific Sessions of the Society for Cardiovascular Magnetic Resonance (SCMR) took place in San Francisco, USA at the end of January 2013. With a faculty of experts from across the world, this congress provided a wealth of insight into cutting-edge research and technological development. This review article intends to provide a highlight of what represented the most significant advances in the field of cardiovascular magnetic resonance (CMR) during this year’s meeting.

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Arrhythmia insensitive rapid cardiac T1 mapping pulse sequence

Cited by 33 publications

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MR fingerprinting for rapid quantification of myocardial T₁ , T₂ , and proton spin density

MR fingerprinting for rapid quantification of myocardial T₁ , T₂ , and proton spin density

Accuracy, Precision, and Reproducibility of Four T1 Mapping Sequences: A Head-to-Head Comparison of MOLLI, ShMOLLI, SASHA, and SAPPHIRE

Highlights of the 16th annual scientific sessions of the Society for Cardiovascular Magnetic Resonance

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Arrhythmia insensitive rapid cardiac T1 mapping pulse sequence

Cited by 33 publications

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MR fingerprinting for rapid quantification of myocardial T1 , T2 , and proton spin density

MR fingerprinting for rapid quantification of myocardial T1 , T2 , and proton spin density

Accuracy, Precision, and Reproducibility of Four T1 Mapping Sequences: A Head-to-Head Comparison of MOLLI, ShMOLLI, SASHA, and SAPPHIRE

Highlights of the 16th annual scientific sessions of the Society for Cardiovascular Magnetic Resonance

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MR fingerprinting for rapid quantification of myocardial T₁ , T₂ , and proton spin density

MR fingerprinting for rapid quantification of myocardial T₁ , T₂ , and proton spin density