2019
DOI: 10.1093/eurheartj/ehz260
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Arrhythmic risk stratification in post-myocardial infarction patients with preserved ejection fraction: the PRESERVE EF study

Abstract: Aims Sudden cardiac death (SCD) annual incidence is 0.6–1% in post-myocardial infarction (MI) patients with left ventricular ejection fraction (LVEF)≥40%. No recommendations for implantable cardioverter-defibrillator (ICD) use exist in this population. Methods and results We introduced a combined non-invasive/invasive risk stratification approach in post-MI ischaemia-free patients, with LVEF ≥ 40%, in a multicentre, prospecti… Show more

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Cited by 117 publications
(121 citation statements)
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“…This allows the assessment of microvolt TWA even in patients with very limited exercise tolerance. We used well-established criteria for each parameter [16].…”
Section: Discussionmentioning
confidence: 99%
“…This allows the assessment of microvolt TWA even in patients with very limited exercise tolerance. We used well-established criteria for each parameter [16].…”
Section: Discussionmentioning
confidence: 99%
“…11 Beyond recommendations about ICD therapy in patients with ischemic cardiomyopathy and poor LVEF, diagnostic algorithms for the identification of patients with relatively preserved LV contractility at increased risk of major arrhythmic events have been proposed. The PRESERVE EF study 12 was performed among 575 patients of mean age 57 years and LVEF 50.8%. Participants were assessed in two steps: if there were abnormalities on ECG (eg, premature ventricular complexes, unsustained ventricular tachycardia, late potentials, prolonged QTc), patients were referred to programmed ventricular stimulation (PVS).…”
Section: Who Is Appropriate For Cieds?mentioning
confidence: 99%
“…The value of SAECG, incorporated in risk‐stratification strategies, is further underscored by a recent study in patients with preserved LV function, undergoing infarct‐scar characterization by cardiac magnetic resonance; wide variation was reported in the extent of potential substrates for monomorphic VT, which correlated with noninvasive indices, including SAECG. Much information on the value of prophylactic ICD implantation in such patients is awaited from the ongoing PRESERVE‐EF study, which examines high‐risk patients, based on complex ventricular tachyarrhythmias, presence of LPs, prolonged QTc, T‐wave alternans, and abnormal autonomic function. The predictive value of such algorithms may be enhanced, if supplemented with the analysis for fragmented QRS complexes on 12‐lead ECG; this promising tool constitutes another marker of depolarization abnormality, representing conduction delay caused by myocardial scar in patients with previous MI …”
Section: Healed Myocardial Infarctionmentioning
confidence: 99%