Arrhythmogenicity of dopamine and its effects on hemodynamics in dogs under halothane anesthesia.

Sato, Takashi; Washizu, Makoto; Kobayashi, Kunito; Misaka, Kazunori; Hayashi, Tarou; Orima, Hiromitsu; Motoyoshi, Shigekatsu

doi:10.1292/jvms1939.51.396

Cited by 5 publications

(7 citation statements)

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“…Recently, Wu et al (9) reported that a high dose of OPC-18790 (3 mg/kg, i.v. ), similar to other drugs which increase calcium inward current, worsened halothane- (10) and acts to increase the arrhythmogenicity of catecholamines (11)(12)(13).…”

Section: Opc-18790 (±)-6-[3-(34-dimethoxybenzylamino)-2-hydroxypropmentioning

confidence: 87%

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Cardiovascular Effects of the Combination of OPC-18790 and Dopamine in Halothane-Anesthetized Dogs

Itoh

Mori

Yoshida

et al. 1995

Japanese Journal of Pharmacology

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ABSTRACT-OPC-18790, (±)-6-[3-(3,4-dimethoxybenzylamino)-2-hydroxypropoxy]-2(1H)-quinolinone, is a novel positive inotropic agent, and its mechanism of positive inotropic action involves not only phosphodiesterase inhibition, but also a prolongation of action potential duration in ventricular muscle. Prolongation of action potential duration is also a property of class III antiarrhythmic agents; therefore, we examined the cardiohemodynamic effects and arrhythmogenicity of a combination of OPC-18790 and dopamine in halothane-anesthetized dogs. Dopamine (5 pg/kg/min) alone increased the peak of the first derivative of left ventricular pressure (LVdP/dtm ) and cardiac output (CO) by 43-48% and 16-20%, respectively, while OPC-18790 (10 pg/kg/min) increased these parameters by 56% and 22%, respectively. The combination of OPC-18790 (10 pg/kg/min) and dopamine (5 pg/kg/min) and dopamine alone at an increased dose of 10 ,pg/kg/min further increased LVdP/dtm , and CO by 104-113% and 29-30%, respectively. Thus, positive inotropic effects were equally observed in both groups, and the effects of OPC-18790 and dopamine seemed to be additive. The other hemodynamic effects were similar among all groups. Arrhythmias such as premature ventricular contraction developed in 5 out of 7 dogs (71.4%) in the 10-pg/kg/min dopamine group, while only one premature ventricular contraction was observed in 1 of 7 dogs (14.3%) in the OPC-18790 (10 pg/kg/min) and dopamine (5 pg/kg/min) combination group. These results suggest that the combination of OPC-18790 and dopamine may provide new therapeutic options for the treatment of heart failure.

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Section: Opc-18790 (±)-6-[3-(34-dimethoxybenzylamino)-2-hydroxypropmentioning

confidence: 87%

“…6). Sato et al (13) reported that ventricular arrhythmias were produced by dopamine infusion at doses of 5 pg/kg/min and above in halothane-anesthetized dogs. Our results concerning the arrhythmogenicity of dopamine are in agreement with this finding.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular Effects of the Combination of OPC-18790 and Dopamine in Halothane-Anesthetized Dogs

Itoh

Mori

Yoshida

et al. 1995

Japanese Journal of Pharmacology

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“…These high doses stimulate sodium and water reabsorption and induce vasoconstriction, resulting in decreased sodium excretion, urinary output, renal blood flow and GFR ( 70 ). Medium and high dopamine dose infusions can provoke arrhythmia, which requires careful subject monitoring ( 71 ). In this study, the dose of dopamine was determined based on previous studies in dogs investigating the effects of dopamine on kidney functions and hemodynamics ( 71–73 ).…”

Section: Discussionmentioning

confidence: 99%

“…Medium and high dopamine dose infusions can provoke arrhythmia, which requires careful subject monitoring ( 71 ). In this study, the dose of dopamine was determined based on previous studies in dogs investigating the effects of dopamine on kidney functions and hemodynamics ( 71–73 ). Dopamine at a low dose was chosen since higher doses do not induce a greater change in renal perfusion, but do affect systemic hemodynamics and cause arrhythmias, posing a greater anesthetic risk ( 71–73 ).…”

Section: Discussionmentioning

confidence: 99%

“…In this study, the dose of dopamine was determined based on previous studies in dogs investigating the effects of dopamine on kidney functions and hemodynamics ( 71–73 ). Dopamine at a low dose was chosen since higher doses do not induce a greater change in renal perfusion, but do affect systemic hemodynamics and cause arrhythmias, posing a greater anesthetic risk ( 71–73 ). In veterinary medicine, dopamine is used in the prevention and treatment of kidney and heart disease ( 72 ).…”

Section: Discussionmentioning

confidence: 99%

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Assessment of pharmacologically induced changes in canine kidney function by multiparametric magnetic resonance imaging and contrast enhanced ultrasound

Hillaert,

Sanmiguel Serpa,

Bogaert

et al. 2024

Front. Vet. Sci.

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IntroductionDynamic contrast-enhanced (DCE) MRI and arterial spin labeling (ASL) MRI enable non-invasive measurement of renal blood flow (RBF), whereas blood oxygenation level-dependent (BOLD) MRI enables non-invasive measurement of the apparent relaxation rate (R2*), an indicator of oxygenation. This study was conducted to evaluate the potential role of these MRI modalities in assessing RBF and oxygenation in dogs. The correlation between contrast-enhanced ultrasound (CEUS) and the MRI modalities was examined and also the ability of the MRI modalities to detect pharmacologically induced changes.MethodsRBF, using CEUS, ASL- and DCE-MRI, as well as renal oxygenation, using BOLD-MRI of eight adult beagles were assessed at two time-points, 2–3 weeks apart. During each time point, the anesthetized dogs received either a control (0.9% sodium chloride) or a dopamine treatment. For each time point, measurements were carried out over 2 days. An MRI scan at 3 T was performed on day one, followed by CEUS on day two.ResultsUsing the model-free model with caudal placement of the arterial input function (AIF) region of interest (ROI) in the aorta, the DCE results showed a significant correlation with ASL measured RBF and detected significant changes in blood flow during dopamine infusion. Additionally, R2* negatively correlated with ASL measured RBF at the cortex and medulla, as well as with medullary wash-in rate (WiR) and peak intensity (PI). ASL measured RBF, in its turn, showed a positive correlation with cortical WiR, PI, area under the curve (AUC) and fall time (FT), and with medullary WiR and PI, but a negative correlation with medullary rise time (RT). During dopamine infusion, BOLD-MRI observed a significant decrease in R2* at the medulla and entire kidney, while ASL-MRI demonstrated a significant increase in RBF at the cortex, medulla and the entire kidney.ConclusionASL- and BOLD-MRI can measure pharmacologically induced changes in renal blood flow and renal oxygenation in dogs and might allow detection of changes that cannot be observed with CEUS. However, further research is needed to confirm the potential of ASL- and BOLD-MRI in dogs and to clarify which analysis method is most suitable for DCE-MRI in dogs.

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Electrophysiologic and proarrhythmic effects of intravenous inotropic agents

Tisdale

Patel

Webb

et al. 1995

Progress in Cardiovascular Diseases

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Arrhythmogenicity of dopamine and its effects on hemodynamics in dogs under halothane anesthesia.

Cited by 5 publications

References 0 publications

Cardiovascular Effects of the Combination of OPC-18790 and Dopamine in Halothane-Anesthetized Dogs

Cardiovascular Effects of the Combination of OPC-18790 and Dopamine in Halothane-Anesthetized Dogs

Assessment of pharmacologically induced changes in canine kidney function by multiparametric magnetic resonance imaging and contrast enhanced ultrasound

Electrophysiologic and proarrhythmic effects of intravenous inotropic agents

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