ARRIGE Arrives: Toward the Responsible Use of Genome Editing

Montoliu, Lluı́s; Merchant, Jennifer; Hirsch, François; Abecassis, Marion; Jouannet, Pierre; Baertschi, Bernard; Menthière, Cyril Sarrauste de; Chneiweiss, Hervé

doi:10.1089/crispr.2018.29012.mon

Cited by 28 publications

(13 citation statements)

References 6 publications

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“…; Montoliu et al. ). This approach is founded on the principle that engineered organisms have the potential to have wide‐ranging impacts that may not be considered by the designers and thus need broader societal input prior to implementation.…”

Section: Ethical Considerations Of Editing Organisms For Conservationmentioning

confidence: 97%

Transforming ecology and conservation biology through genome editing

Phelps

Seeb

2019

Conservation Biology

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As the conservation challenges increase, new approaches are needed to help combat losses in biodiversity and slow or reverse the decline of threatened species. Genome-editing technology is changing the face of modern biology, facilitating applications that were unimaginable only a decade ago. The technology has the potential to make significant contributions to the fields of evolutionary biology, ecology, and conservation, yet the fear of unintended consequences from designer ecosystems containing engineered organisms has stifled innovation. To overcome this gap in the understanding of what genome editing is and what its capabilities are, more research is needed to translate genome-editing discoveries into tools for ecological research. Emerging and future genome-editing technologies include new clustered regularly interspaced short palindromic repeats (CRISPR) targeted sequencing and nucleic acid detection approaches as well as species genetic barcoding and somatic genome-editing technologies. These genome-editing tools have the potential to transform the environmental sciences by providing new noninvasive methods for monitoring threatened species or for enhancing critical adaptive traits. A pioneering effort by the conservation community is required to apply these technologies to real-world conservation problems.

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Section: Ethical Considerations Of Editing Organisms For Conservationmentioning

confidence: 97%

Transforming ecology and conservation biology through genome editing

Phelps

Seeb

2019

Conservation Biology

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“…The implementation of such principles in practice has proven somewhat challenging. While Montoliu, et al [37] have illustrated how comprehension and endorsement of experiments on animals in laboratory can benefit from openness and transparency, the result of Bremer, et al [38] experimental engagement with the full spectrum of aquaculture stakeholders are more nuanced. Starting from the normative principle that responsible decisions can be made solely by engaging with the multiplicity of ethical concerns, the researcher assembled 27 types of stakeholders, including individuals and organization representing, or claiming to represent, producers, the scientific community, the aquaculture industry at large, including input suppliers, processors, retail distributor, consumers, the environment and even the fish themselves.…”

Section: Literature Reviewmentioning

confidence: 99%

RRI and Corporate Stakeholder Engagement: The Aquadvantage Salmon Case

Callegari

Михайлова

2021

Sustainability

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Declining public trust in science and innovation triggered the emergence and development of the responsible research and innovation (RRI) concept among policymakers and academics. Engaging stakeholders in the early phases of innovation processes has been identified as a major driver of inclusive, responsible, and sustainable development. Firms however have often adopted practices entirely opposite to those being advocated within the RRI framework, namely, reducing external interaction with stakeholders, focusing on exclusive communication with the scientific community and legal authorities while avoiding the social spotlight. We illustrate these practices, their causes and consequences using the case of the Aquadvantage salmon, the first genetically modified (GM) animal approved to petition for the United States (US) Food and Drug Administration (FDA) approval for human consumption. We find that such practices heighten the risk of social backlash, being undesirable from the perspective of both the organizations involved and society at large. Stakeholder engagement remains necessary in order to gain the minimum social acceptance required for contentious innovative products to enter the market. However, stakeholder engagement must be selective, focused on pragmatic organizations whose aims and interests are sufficiently broad to potentially align with corporate interests. Strategic stakeholder engagement offers a meeting point between the transformative aspirations of RRI framework proponents and legitimate business interests.

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“…The promising use of CRISPR as a tool for gene editing to treat defective unborn children, involving the success and accessibility of diagnosis and design, the treatment has generated debates among researchers to propose ethical guidelines for approval of this approach in preclinical settings (Curtis 2011 ). A survey conducted in 2018 of over 2500 Americans (Montoliu et al 2018 ) showed general knowledge and acceptance of the idea for gene surgery in human embryos. While the vast majority of the USA population are not in favor of vaccination, blood transfusion, in vitro fertilization and organ transplant to save lives, it is difficult to press the issue to support the potential application of CRISPR in mankind to treat serious diseases.…”

Section: Ethical Factors For Therapeutic Application Of Crisprmentioning

confidence: 99%

CRISPR: a journey of gene-editing based medicine

Golkar

2020

Genes Genom

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CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat) is one of the hallmark of biological tools, contemplated as a valid and hopeful alternatives to genome editing. Advancements in CRISPR-based technologies have empowered scientists with an editing kit that allows them to employ their knowledge for deleting, replacing and lately “Gene Surgery”, and provides unique control over genes in broad range of species, and presumably in humans. These fast-growing technologies have high strength and flexibility and are becoming an adaptable tool with implementations that are altering organism’s genome and easily used for chromatin manipulation. In addition to the popularity of CRISPR in genome engineering and modern biology, this major tool authorizes breakthrough discoveries and methodological advancements in science. As scientists are developing new types of experiments, some of the applications are raising questions about what CRISPR can enable. The results of evidence-based research strongly suggest that CRISPR is becoming a practical tool for genome-engineering and to create genetically modified eukaryotes, which is needed to establish guidelines on new regulatory concerns for scientific communities.

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ARRIGE Arrives: Toward the Responsible Use of Genome Editing

Cited by 28 publications

References 6 publications

Transforming ecology and conservation biology through genome editing

Transforming ecology and conservation biology through genome editing

RRI and Corporate Stakeholder Engagement: The Aquadvantage Salmon Case

CRISPR: a journey of gene-editing based medicine

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