Arritmias ventriculares en superrespondedores a la terapia de resincronización cardiaca

García‐Lunar, Inés; Castro, Victor; Toquero‐Ramos, Jorge; Mingo-Santos, Susana; Moñivas-Palomero, Vanessa; Mitroi, Cristina; Sánchez-García, Manuel; Pérez-Pereira, Elena; Delgado, Hugo E.; Fernández‐Lozano, Ignacio

doi:10.1016/j.recesp.2014.01.017

Cited by 21 publications

(2 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We found super-response was associated with a reduced occurrence of all-cause death or HF hospitalization, which was consistent with the previous studies [4, 5, 18, 20, 21]. Moreover, a previous study reported that the patients considered as super-responders had a significantly reduced incidence of ventricular arrhythmias [22]. Similarly, Killu et al demonstrated that the super-response to CRT-D group had very low rates of ventricular arrhythmias requiring implantable cardioverter defibrillator (ICD) therapy compared with the non-super-response to CRT-D group [23].…”

Section: Discussionsupporting

confidence: 92%

Heart Failure Duration Combined with Left Atrial Dimension Predicts Super-Response and Long-Term Prognosis in Patients with Cardiac Resynchronization Therapy Implantation

Guo

Liu

et al. 2019

BioMed Research International

View full text Add to dashboard Cite

Background. Response to cardiac resynchronization therapy (CRT) varies significantly among patients. This study aimed to identify baseline characteristics that could predict super-response to CRT and to evaluate the long-term prognosis in super-responders. Methods. We retrospectively reviewed the data of 73 consecutive patients who received CRT. Patients were considered as super-responders after 6-month follow-up when NYHA class reduction to I or II combined with left ventricular ejection fraction (LVEF) ≥ 50% was observed. Patients were divided into super-responders group and non-super-responders group. All-cause mortality or hospitalization for heart failure (HF) was referred to the combined end point. Results. 17 (23.3%) patients were super-responders. HF duration, left atrial dimension (LAD), and left bundle branch block (LBBB) were independent predictors of super-response to CRT. The combination of HF duration and LAD could provide more robust prediction of super-response than standalone HF duration (0.899 versus 0.789, Z = 2.207, P = 0.027) or standalone LAD (0.899 versus 0.775, Z = 2.487, P = 0.013). super-responders had excellent LV reverse remodeling. The cumulative incidences of combined end point were significantly lower in the super-responders group, LAD ≤ 42mm group, and combination of HF duration ≤ 48 months and LAD ≤ 42mm group. LBBB remained associated with a lowered risk of the combined end point (HR: 0.19, 95% CI: 0.07-0.57, P = 0.003), whereas LAD was associated with a raised risk of the combined end point (HR: 1.09, 95% CI: 1.02-1.17, P = 0.014). Conclusions. HF duration, LAD, and LBBB independently predicted super-response. The combination of HF duration and LAD makes more robust prediction of CRT super-response. Super-responders had excellent LV reverse remodeling and decreased the incidences of the combined end point. LBBB and LAD were independently associated with the combined end point.

show abstract

Section: Discussionsupporting

confidence: 92%

Heart Failure Duration Combined with Left Atrial Dimension Predicts Super-Response and Long-Term Prognosis in Patients with Cardiac Resynchronization Therapy Implantation

Guo

Liu

et al. 2019

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Por otro lado, la ausencia de eventos arrítmicos en los pacientes con normalización precoz y mantenida de la FE es un hallazgo concordante con los de García-Lunar et al 7 , que evidencian en una serie de 196 pacientes con seguimiento de 30 meses una presencia mínima (5,6%) de arritmias ventriculares en pacientes hiperrespondedores frente al resto (46,6%). En este caso no se trataba únicamente de pacientes con miocardiopatía dilatada idiopática, por lo que las diferencias aún podrían ser mayores y justificar las pequeñas diferencias en nuestra serie.…”

Section: Discussionunclassified

La normalización precoz de la fracción de eyección tras resincronización en miocardiopatía dilatada idiopática es mantenida a largo plazo e identifica el mejor pronóstico clínico y arrítmico

et al. 2015

View full text Add to dashboard Cite

Decision making for upgrading or downgrading a CRT device regarding ethical, medical, and economic issues

Kallergis

Simantirakis

Nakou

et al. 2016

Continuing Cardiol Educ

View full text Add to dashboard Cite

There are limited data about the management of patients presenting for elective generator replacements in the setting of previously implanted implantable cardioverter defibrillator (ICD) or cardiac resynchronization therapy (CRT) devices that are nearing end of life. Over a patient's life span, clinical situations evolve and previously present conditions that merited CRT implantation may change. The individual patient's clinical status and concomitant illnesses may evolve so that considerations may include not only replacement of the pulse generator but also potentially changing the type of device [e.g., downgrading CRT-defibrillator (CRT-D) to CRT-pacemaker (CRT-P) or ICD or upgrading of CRT-P to CRT-D]. Moreover, the clinical evidence for CRT-D/ CRT-P placement may evolve over time, with ongoing research and availability of new trial data. In this review we discuss the ethical, medical, and financial implications related to CRT generator replacements and the need for additional clinical trials to better understand which patients should undergo downgrading or upgrading.

show abstract

Arritmias ventriculares en superrespondedores a la terapia de resincronización cardiaca

Cited by 21 publications

References 27 publications

Heart Failure Duration Combined with Left Atrial Dimension Predicts Super-Response and Long-Term Prognosis in Patients with Cardiac Resynchronization Therapy Implantation

Heart Failure Duration Combined with Left Atrial Dimension Predicts Super-Response and Long-Term Prognosis in Patients with Cardiac Resynchronization Therapy Implantation

La normalización precoz de la fracción de eyección tras resincronización en miocardiopatía dilatada idiopática es mantenida a largo plazo e identifica el mejor pronóstico clínico y arrítmico

Decision making for upgrading or downgrading a CRT device regarding ethical, medical, and economic issues

Contact Info

Product

Resources

About