Arsenal of Phytochemicals to Combat Against Arsenic-Induced Mitochondrial Stress and Cancer

Sarkar, Nivedita; Das, Bornita; Bishayee, Anupam; Sinha, Dona

doi:10.1089/ars.2019.7950

Cited by 14 publications

(6 citation statements)

References 190 publications

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“…Silybum marianum was found to inhibit caspase-3-mediated tubular cell apoptosis and down-regulate the expression of nicotinamide adenine dinucleotide (NADPH) oxidase, inducible gas synthase (iNOS), and NF-κB in renal tissues as well as preserve the traditional structure of renal tissues in rats exposed to arsenic . Epigallocatechin-3-gallate (EGCG), an ester of epigallocatechin and gallic acid, is a major flavonoid present in green tea, which was found to be effective in the removal of arsenic-induced testicular toxicity of male Swiss mice . EGCG was found to be effective in ameliorating arsenic toxicity in several studies performed using different animal models.…”

Section: Phytochemicals and Their Use To Manage Arsenic Toxicitymentioning

confidence: 99%

“…This in turn converts the polyphenolic antioxidant (PhOH) to a phenoxy radical (PhO•), which may interact with each other, thus neutralizing the ROS (reaction ). Flavonoids generally have properties ranging from antioxidant and anti-inflammatory effects and reactive oxygen species scavenging activity to chelating metal/metalloid ions. , Phase II detoxifying enzymes induced by polyphenolic compounds such as glutathione-S-transferase and CYP (cytochromes P450)-mediated detoxification are responsible for the detoxification of toxicants. Taurine, quercetin, silymarin, rutin, and the mixed polyphenolic flavonoids present in green tea leaves exert a protective action against As-caused damage through their antioxidant and chelating abilities. …”

Section: Phytochemicals and Their Use To Manage Arsenic Toxicitymentioning

confidence: 99%

“…20 Epigallocatechin-3-gallate (EGCG), an ester of epigallocatechin and gallic acid, is a major flavonoid present in green tea, which was found to be effective in the removal of arsenic-induced testicular toxicity of male Swiss mice. 92 EGCG was found to be effective in ameliorating arsenic toxicity in several studies performed using different animal models. EGCG decreased immunosuppression and inflammation in arsenicexposed mice.…”

Section: Phytochemicals and Their Use To Manage Arsenic Toxicitymentioning

confidence: 99%

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Phytochemicals in the Management of Arsenic Toxicity

Khan

Sharma

Flora

2022

Chem. Res. Toxicol.

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Arsenic toxicity is a major concern due to its deleterious consequences for human health. Rapid industrialization also has weakened the quality of the environment by introducing pollutants that may disrupt balanced ecosystems, adversely and irreversibly impacting humans, plants, and animals. Arsenic, an important toxicant among all environmental hazards, can lead to several detrimental effects on cells and organs, impacting the overall quality of life. Nevertheless, arsenic also has a rich history as a chemotherapeutic agent used in ancient days for the treatment of diseases such as malaria, cancer, plague, and syphilis when other chemotherapeutic agents were yet to be discovered. Arsenicosis-mediated disorders remain a serious problem due to the lack of effective therapeutic options. Initially, chelation therapy was used to metabolically eliminate arsenic by forming a complex, but adverse effects limited their pharmacological use. More recently, plant-based products have been found to provide significant relief from the toxic effects of arsenic poisoning. They act by different mechanisms affecting various cellular processes. Phytoconstituents such as curcumin, quercetin, diallyl trisulfide, thymoquinone, and others act via various molecular pathways, primarily by attenuating oxidative damage, membrane damage, DNA damage, and proteinopathies. Nonetheless, most of the phytochemicals reviewed here protect against the adverse effects of metal or metalloid exposure, supporting their consideration as alternatives to chelation therapy. These agents, if used prophylactically and in conjunction with other chemotherapeutic agents, may provide an effective approach for management of arsenic toxicity. In a few instances, such strategies like coadministration of phytochemicals with a known chelating agent have led to more pronounced elimination of arsenic from the body with lesser off-site adverse effects. This is possible because combination treatment ensures the use of a reduced dose of chelating agent with a phytochemical without compromising treatment. Thus, these therapies are more practical than conventional therapeutic agents in ameliorating arsenic-mediated toxicity. This review summarizes the potential of phytochemicals in alleviating arsenic toxicity on the basis of available experimental and clinical evidence.

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Section: Phytochemicals and Their Use To Manage Arsenic Toxicitymentioning

confidence: 99%

Section: Phytochemicals and Their Use To Manage Arsenic Toxicitymentioning

confidence: 99%

Section: Phytochemicals and Their Use To Manage Arsenic Toxicitymentioning

confidence: 99%

See 1 more Smart Citation

Phytochemicals in the Management of Arsenic Toxicity

Khan

Sharma

Flora

2022

Chem. Res. Toxicol.

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“…In addition to biological trace elements, food-derived bioactive compounds that can attenuate oxidative stress and inflammation have protective potential against arsenic-induced tissue damage [ 83 ]. The most notable of the natural compounds are curcumin, quercetin, gallic acid, genistein, resveratrol, and thymoquinone, whose protective effects against arsenic toxicity have been supported by multiple studies in animals [ 84 , 85 ].…”

Section: Management and Control Of Arsenic-induced Neurological Deficitsmentioning

confidence: 99%

Exposure to Environmental Arsenic and Emerging Risk of Alzheimer’s Disease: Perspective Mechanisms, Management Strategy, and Future Directions

Rahman

Hannan

Uddin

et al. 2021

Toxics

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Alzheimer’s disease (AD) is one of the most prevailing neurodegenerative diseases, characterized by memory dysfunction and the presence of hyperphosphorylated tau and amyloid β (Aβ) aggregates in multiple brain regions, including the hippocampus and cortex. The exact etiology of AD has not yet been confirmed. However, epidemiological reports suggest that populations who were exposed to environmental hazards are more likely to develop AD than those who were not. Arsenic (As) is a naturally occurring environmental risk factor abundant in the Earth’s crust, and human exposure to As predominantly occurs through drinking water. Convincing evidence suggests that As causes neurotoxicity and impairs memory and cognition, although the hypothesis and molecular mechanism of As-associated pathobiology in AD are not yet clear. However, exposure to As and its metabolites leads to various pathogenic events such as oxidative stress, inflammation, mitochondrial dysfunctions, ER stress, apoptosis, impaired protein homeostasis, and abnormal calcium signaling. Evidence has indicated that As exposure induces alterations that coincide with most of the biochemical, pathological, and clinical developments of AD. Here, we overview existing literature to gain insights into the plausible mechanisms that underlie As-induced neurotoxicity and the subsequent neurological deficits in AD. Prospective strategies for the prevention and management of arsenic exposure and neurotoxicity have also been discussed.

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“…In addition to biological trace elements, food-derived bioactive compounds that can attenuate oxidative stress and inflammation have protective potential against arsenic-induced tissue damage [84]. The most notable of the natural compounds are curcumin, quercetin, gallic acid, genistein, resveratrol, and thymoquinone whose protective effects against arsenic toxicity have been supported by multiple studies in animals [85,86].…”

Section: Management and Control Of Arsenic-induced Neurological Deficitsmentioning

confidence: 99%

Exposure to Environmental Factor Arsenic and Emerging Risk of Alzheimer’s Disease: Perspective Mechanisms, Management Strategy, And Future Directions

Rahman¹,

Hannan²,

Uddin³

et al. 2021

Preprint

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Alzheimer’s disease (AD) is one of the most prevailing neurodegenerative diseases, characterized by memory dysfunction and the presence of hyperphosphorylated tau and amyloid β (Aβ) aggregate in multiple brain regions, including the hippocampus and cortex. The exact etiology of AD has not yet been confirmed. However, epidemiological reports suggest that populations who were exposed to environmental hazards are more likely to develop AD than those who were not. Arsenic (As) is a naturally occurring environmental risk factor abundant in the Earth’s crust and human exposure to As predominantly occurs through drinking water. Convincing evidence suggests that As causes neurotoxicity and impairs memory and cognition although the hypothesis and molecular mechanism of As-associated pathobiology in AD are not clear yet. However, exposure to As and its metabolites leads to various pathogenic events such as oxidative stress, inflammation, mitochondrial dysfunctions, ER stress, apoptosis, impaired protein homeostasis, and abnormal calcium signaling. Evidence has indicated that As exposure induces alterations that coincide with most of the biochemical, pathological, and clinical developments of AD. Here, we overview existing literature to gain insights into the plausible mechanisms that underlie As-induced neurotoxicity and the subsequent neurological deficits in AD. Prospective strategies for the prevention and management of arsenic exposure and neurotoxicity have also been discussed.

show abstract

Arsenal of Phytochemicals to Combat Against Arsenic-Induced Mitochondrial Stress and Cancer

Cited by 14 publications

References 190 publications

Phytochemicals in the Management of Arsenic Toxicity

Phytochemicals in the Management of Arsenic Toxicity

Exposure to Environmental Arsenic and Emerging Risk of Alzheimer’s Disease: Perspective Mechanisms, Management Strategy, and Future Directions

Exposure to Environmental Factor Arsenic and Emerging Risk of Alzheimer’s Disease: Perspective Mechanisms, Management Strategy, And Future Directions

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