Arsenic and Immune Response to Infection During Pregnancy and Early Life

Attreed, Sarah E.; Navas‐Acien, Ana; Heaney, Christopher D.

doi:10.1007/s40572-017-0141-4

Cited by 40 publications

(24 citation statements)

References 77 publications

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“…The mechanism(s) associated with arsenic immunosuppression are likely due to a combination of genotoxic and non-genotoxic actions on lymphoid cells. The consequences of immunosuppression produced by arsenic include an increased susceptibility to infections [3,24,26,27]. The genotoxic actions of arsenic are likely due to increased DNA damage and oxidative stress [21,[28][29][30][31][32].…”

Section: Discussionmentioning

confidence: 99%

Arsenic exposure associated T cell proliferation, smoking, and vitamin D in Bangladeshi men and women

et al. 2020

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There are limited data examining the consequences of environmental exposure to arsenic on the immune system in adults, particularly among smokers. Smoking has been shown to exacerbate or contribute to impaired immune function in men chronically exposed to arsenic. In contrast, vitamin D (VitD) is known to have a positive influence on innate and adaptive immune responses. The effect of circulating VitD on arsenic-associated immune dysfunction is not known. Here we examine the relationship of arsenic exposure and T cell proliferation (TCP), a measure of immune responsiveness, and circulating VitD among adult men and women in Bangladesh. Arsenic exposure was assessed using total urinary arsenic as well as urinary arsenic metabolites all adjusted for urinary creatinine. TCP was measured ex vivo in cryopreserved peripheral blood mononuclear cells from 614 adult participants enrolled in the Bangladesh Health Effects of Arsenic Longitudinal Study; serum VitD was also evaluated. The influence of cigarette smoking on arsenic-induced TCP modulation was assessed only in males as there was an inadequate number of female smokers. These studies show that arsenic suppressed TCP in males. The association was significantly strong in male smokers and to a lesser extent in male non-smokers. Interestingly, we found a strong protective effect of high/sufficient serum VitD levels on TCP among non-smoking males. Furthermore, among male smokers with low serum VitD (t20 ng/ml), we found a strong suppression of TCP by arsenic. On the other hand, high VitD (>20 ng/ml) was found to attenuate effects of arsenic on TCP among male-smokers. Overall, we found a strong protective effect of VitD, when serum levels were >20 ng/ml, on arsenic-induced inhibition of TCP in men,

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Section: Discussionmentioning

confidence: 99%

Arsenic exposure associated T cell proliferation, smoking, and vitamin D in Bangladeshi men and women

et al. 2020

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“…Despite a significant number of epidemiological studies that have examined the influence of environmental arsenic exposure on cancer [33, 34], cardiovascular disease [6, 35] altered lung function [36], and infection [14, 37–39], there are only a few studies that examined the effects of chronic arsenic exposure on the human immune system. This is somewhat surprising as the immune system in known to play a critical role in protection from infections and immune surveillance of cancer.…”

Section: Discussionmentioning

confidence: 99%

Assessment of arsenic and polycyclic aromatic hydrocarbon (PAH) exposures on immune function among males in Bangladesh

et al. 2019

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Arsenic and polycyclic aromatic hydrocarbons (PAH) are environmental pollutants to which people around the world are exposed through water, food and air. In mouse and in vitro studies of human cells, both of these chemicals have been shown to modulate the immune system. In some experimental studies, a synergistic disruption of immune function was observed by a combined exposure to arsenic and PAH. However, a joint effect of arsenic and PAH on immune function has not been studied in humans. We have conducted an epidemiological investigation to examine effects of chronic arsenic and PAH exposures on immune function. We assessed T-cell proliferation (TCP) and cytokine production of anti-CD3/anti-CD28 stimulated lymphocytes in human peripheral blood mononuclear cells (HPBMC) among 197 healthy men enrolled to the Health Effects of Arsenic Longitudinal (HEALS) cohort in Bangladesh. By design, approximately half were active smokers and the rest were never smokers. Our analyses demonstrated that IL-1b, IL-2, IL-4 and IL-6 were significantly stimulated as a function of urinary arsenic levels in models adjusted for age, body mass index (BMI), smoking status and PAH-DNA adducts. After correcting for false detection rate (FDR), only IL-1b remained statistically significant. We found a U-shaped dose response relationship between urinary arsenic and IL-1b. On the other hand, PAH-DNA adducts were associated with an inhibition of TCP and appeared as an inverted U-shape curve. Dose response curves were non-monotonic for PAH-DNA adduct exposures and suggested that cytokine secretion of IFNg, IL-1b, IL-2, IL-10 and IL17A followed a complex pattern. In the majority of donors, there was a trend towards a decrease in cytokine associated with PAH-DNA adducts. We did not observe any interaction between urinary arsenic and PAH-DNA adducts on immune parameters. Our results indicate that long-term exposures to arsenic and PAH have independent, non-monotonic associations with TCP and cytokine production.

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“…Future experimental and human studies could help address this knowledge gap by evaluating the differential effects of high to moderate exposure to each of these chemicals. Humoral immune function seems to be less prone to impairment by either arsenic or lead compared to cellmediated immunity [8,59]. Additional work examining the impact of both humoral and cell-mediated immunity in the context of metal mixtures would help determine the interplay between these interrelated immune processes and prevalent exposures.…”

Section: Discussionmentioning

confidence: 99%

“…Experimental studies also show that arsenic impairs the function of T-cells, macrophages, and several other immune system cells [5][6][7]. Prospective cohort studies report that arsenic exposure increases infectious disease risk in the first year of life [8]. Additionally, prenatal and early childhood arsenic exposure is associated with suppressed cell-mediated immunity and modulation of humoral immunity via altered immunoglobulin (Ig) profiles [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Evaluating the effects between metal mixtures and serum vaccine antibody concentrations in children: a prospective birth cohort study

et al. 2020

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Background: Many populations are exposed to arsenic, lead, and manganese. These metals influence immune function. We evaluated the association between exposure to single and multiple metals, including arsenic, lead, and manganese, to humoral immunity as measured by antibody concentrations to diphtheria and tetanus toxoid among vaccinated Bangladeshi children. Additionally, we examined if this association was potentially mediated by nutritional status. Methods: Antibody concentrations to diphtheria and tetanus were measured in children's serum at age 5 (n = 502). Household drinking water was sampled to quantify arsenic (W-As) and manganese (W-Mn), whereas lead was measured in blood (B-Pb). Exposure samples were taken during pregnancy, toddlerhood, and early childhood. Multiple linear regression models (MLRs) with single or combined metal predictors were used to determine the association with antibody outcomes. MLR results were transformed to units of percent change in outcome per doubling of exposure to improve interpretability. Structural equation models (SEMs) were used to further assess exposure to metal mixtures. SEMs regressed a latent exposure variable (Metals), informed by all measured metal variables (W-As, W-Mn, and B-Pb), on a latent outcome variable (Antibody), informed by measured antibody variables (diphtheria and tetanus). Weight-forage z-score (WFA) at age 5 was evaluated as a mediator.

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Arsenic and Immune Response to Infection During Pregnancy and Early Life

Cited by 40 publications

References 77 publications

Arsenic exposure associated T cell proliferation, smoking, and vitamin D in Bangladeshi men and women

Arsenic exposure associated T cell proliferation, smoking, and vitamin D in Bangladeshi men and women

Assessment of arsenic and polycyclic aromatic hydrocarbon (PAH) exposures on immune function among males in Bangladesh

Evaluating the effects between metal mixtures and serum vaccine antibody concentrations in children: a prospective birth cohort study

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