Arsenic concentrations in well water and risk of bladder and kidney cancer in Finland.

Kurttio, Päivi; Pukkala, Eero; Kahelin, Hanna; Auvinen, A; Pekkanen, Juha

doi:10.1289/ehp.99107705

Cited by 254 publications

(120 citation statements)

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“…Most of the available studies have been conducted in areas at elevated arsenic content (typically above 200 mg/l). The results of studies of bladder cancer conducted in areas with low or intermediate contamination are suggestive of a possible increased risk (Bates et al, 1995;Kurttio et al, 1999).…”

Section: Cancer Risk From Inorganic Arsenic In Drinking Watermentioning

confidence: 99%

Epidemiology of environmental and occupational cancer

Boffetta

2004

Oncogene

123

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Environmental carcinogens, in a strict sense, include outdoor and indoor air pollutants, as well as soil and drinking water contaminants. An increased risk of mesothelioma has consistently been detected among individuals experiencing residential exposure to asbestos, while results for lung cancer are less consistent. Several good-quality studies have investigated lung cancer risk from outdoor air pollution based on measurement of specific agents. Their results tend to show an increased risk in the categories at highest exposure, with relative risks in the range 1.5. A causal association has been established between exposure to environmental tobacco smoke and lung cancer, with a relative risk in the order of 1.2. Radon is another carcinogen present in indoor air, with a relative risk in the order of 1.06 for exposure at 100 Bq/m 3 . In several Asian populations, an increased risk of lung cancer results among women from indoor pollution from cooking and heating. There is strong evidence of an increased risk of bladder, skin and lung cancers following consumption of water with high arsenic contamination; results for other drinking water contaminants, including chlorination by-products, are inconclusive. A total of 29 occupational agents are established human carcinogens, and another 30 agents are suspected carcinogens. In addition, at least 12 exposure circumstances entail exposure to carcinogens. Exposure is still widespread for many important occupational carcinogens, such as asbestos, coal tar, arsenic and silica, in particular in developing countries. Although estimates of the global burden of occupational and environmental cancer result in figures in the order of 2% and less than 1%, respectively, these cancers concentrate in subgroups of the population; furthermore, exposure is involuntary and can, to a large extent, be avoided.

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Section: Cancer Risk From Inorganic Arsenic In Drinking Watermentioning

confidence: 99%

Epidemiology of environmental and occupational cancer

Boffetta

2004

Oncogene

123

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“…There was no association between kidney cancer and As exposure (Kurttio et al, 1999). This research showed relatively low As doses can lead to internal cancers.…”

Section: Internal Malignanciesmentioning

confidence: 56%

“…A cohort study on bladder and kidney cancers relating to As exposure in Finland found a significant elevation of bladder cancer risk among the subjects that were exposed over 0.5 μg As/L in the drinking water or to a daily dose of 1.0 μg for from 3 to 9 years before diagnosis (Kurttio et al, 1999). There was no association between kidney cancer and As exposure (Kurttio et al, 1999).…”

Section: Internal Malignanciesmentioning

confidence: 99%

Chronic health effects in people exposed to arsenic via the drinking water: dose?response relationships in review

Yoshida¹

2004

Toxicology and Applied Pharmacology

517

266

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Chronic arsenic (As) poisoning has become a world wide public health issue.Most human As exposure occurs from consumption of drinking water containing high amounts of inorganic As (iAs). In this paper, epidemiological studies conducted on the dose-response relationships between iAs exposure via the drinking water and related adverse health effects are reviewed. Before the review, the methods for evaluation of the individual As exposure are summarized and classified into two types, i.e. the methods depending on As concentration of the drinking water and the methods depending on biological monitoring for As exposure; certain methods may be applied as optimum As exposure indexes to study dose-response relationship based on various As exposure situation. Chronic effects of iAs exposure via drinking water include skin lesions, neurological effects, hypertension, peripheral vascular disease, cardiovascular disease, respiratory disease, diabetes mellitus, and malignancies including skin cancer.The skin is quiet sensitive to arsenic and skin lesions are some of the most common and earliest non-malignant effects related to chronic As exposure. The increase of prevalence in the skin lesions has been observed even at the exposure levels in the range of 0.005-0.01 mg/L As in drinking waters. Skin, lung, bladder, kidney, liver and uterus are considered as sites As-induced malignancies, and the skin is though to be perhaps the most sensitive site. Prospective studies in large area of endemic As poisoning, like Bangladesh or China, where the rate of malignancies is expected to increase within the next several decades, will help to clarify the dose-response relationship between As exposure levels and adverse health effects with enhanced accuracy.

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“…22 The study population was selected from a register-based cohort of all Finns who had lived at an address outside the municipal drinking water system during 1967-1980 (n= 144,627). The final study population consisted of 61 bladder cancer cases, 49 kidney cancer cases diagnosed between 1981 and 1995 and age and sex matched random sample reference cohort (n= 275).…”

Section: Current Researchmentioning

confidence: 99%

Renal cell Cancer, Environmental Arsenic Exposure and Carcinogenic Mutations

Tanrıöver¹

2012

UHOD

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Malignant tumors of the kidney accounts for approximately 2-3% of the all new primary cancers cases diagnosed in the US, with an estimated 60.000 cases occurring annually. Current epidemiological studies provide convincing evidence linking environmental arsenic exposure to an elevated risk of renal cell carcinoma (RCC). High levels of arsenic leaching from natural underground sources have contaminated newly drilled wells, leading to cancers of the skin, lung, liver, kidney, and bladder. This link has been the basis for regulatory actions. In 2002, the US Environmental Protection Agency (EPA) lowered the maximum contaminant level for the amount of arsenic allowed in drinking water from 50 ppb to 10 ppb (10 µ/L). In addition, recent molecular biology research on familial kidney cancer syndromes indicate that inactivation mutation in VHL tumor suppressor gene contributes to clear cell RCC development. Future studies using animal models are needed to explain genetic susceptibility in VHL mutations and carcinogenic effect of arsenic exposure.Keywords: Arsenic, Environmental exposure, Renal cell carcinoma OZET Böbrek Kanserinin Gelifliminde Arsenik ve Karsinojenik Mutasyonlar›n RolüAmerika Birleflik Devletleri'nde her sene 60,000 civar›nda yeni böbrek kanserine tan› konulmakta ve bu bütün kanserlerin %2-3'ünü oluflturmaktad›r. Epidemiyolojik araflt›rmalar, çevresel arseni¤e maruz kalanlarda böbrek kanser riskinin artt›¤›n› göstermifllerdir. Bu araflt›rmalar, daha çok içme suyu kuyudan temin edilen k›rsal alanlarda ve az geliflmifl ülkelerde yap›lm›fl ve arseni¤e kronik olarak 10 ppb (10 µg/L)' den daha fazla konsantrasyonlarda maruz kalanlarda gosterilmifltir. Günümüze kadar molekuler seviyede arsenik toksisitesinin karsinojenik ve mutagenik etkisi henüz çal›fl›lmam›flt›r. Di¤er taraftan, ailesel böbrek kanseri (von Hippel-Lindau sendromu) olan hastalarda yap›lan genetik çal›flmalar, VHL tumor supresor genindeki inaktivasyon mutasyonunun en s›k rastlanan böbrek kanser çesidi olan fleffaf hücreli kansere sebep oldu¤u gosterilmifltir. S›k rastlanan bir halk sa¤l›¤› problemi olmas› itabariyle, gelecekte hayvan modelleriyle VHL mutasyonu ve arseni¤in kanserojenik etkisinin çal›fl›lmas› önemli bir araflt›rma konusu olarak yerini korumaktad›r.

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Arsenic concentrations in well water and risk of bladder and kidney cancer in Finland.

Cited by 254 publications

References 26 publications

Epidemiology of environmental and occupational cancer

Epidemiology of environmental and occupational cancer

Chronic health effects in people exposed to arsenic via the drinking water: dose?response relationships in review

Renal cell Cancer, Environmental Arsenic Exposure and Carcinogenic Mutations

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