Arsenic Exposure and Diabetes Mellitus in the United States

Tseng, Chin‐Hsiao

doi:10.1001/jama.2008.812

Cited by 9 publications

(6 citation statements)

References 19 publications

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“…Both acute and chronic health effects have been investigated, and their types and magnitude vary greatly depending on the dose and species of arsenic, as well as on specific intrinsic and extrinsic factors . The clinical and pathological manifestations of arsenicosis have been widely reported, and include black foot disease in Taiwan, atherosclerosis, cerebral infarction, hypertension, diabetes mellitus, skin pathologies, liver and lung fibrosis, hearing loss, and neurologic damage in children . However, many of these clinical endpoints do not show strong scientific evidence.…”

Section: Epidemiology Of Arsenic Toxicitymentioning

confidence: 99%

“…Research on industrial studies on workers points to arsenic association with lung cancer risk . It is probable that i As acts in conjunction with other related risk factors such as radiation, asbestos, radon, nickel, chromates, as well as genetic and nutritional factors . Many population‐based studies on populations consuming high i As concentrations have reported higher risk of lung neoplasm .…”

Section: Epidemiology Of Arsenic Toxicitymentioning

confidence: 99%

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State of the science review of the health effects of inorganic arsenic: Perspectives for future research

Tchounwou

Yedjou

Udensi

et al. 2018

Environmental Toxicology

134

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Human exposure to inorganic arsenic (iAs) is a global health issue. Although there is strong evidence for iAs-induced toxicity at higher levels of exposure, many epidemiological studies evaluating its effects at low exposure levels have reported mixed results. We comprehensively reviewed the literature and evaluated the scientific knowledge on human exposure to arsenic, mechanisms of action, systemic and carcinogenic effects, risk characterization, and regulatory guidelines. We identified areas where additional research is needed. These priority areas include: (1) further development of animal models of iAs carcinogenicity to identify molecular events involved in iAs carcinogenicity; (2) characterization of underlying mechanisms of iAs toxicity; (3) assessment of genderspecific susceptibilities and other factors that modulate arsenic metabolism; (4) sufficiently powered epidemiological studies to ascertain relationship between iAs exposure and reproductive/ developmental effects; (5) evaluation of genetic/epigenetic determinants of iAs effects in children;and (6) epidemiological studies of people chronically exposed to low iAs concentrations.

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Section: Epidemiology Of Arsenic Toxicitymentioning

confidence: 99%

Section: Epidemiology Of Arsenic Toxicitymentioning

confidence: 99%

State of the science review of the health effects of inorganic arsenic: Perspectives for future research

Tchounwou

Yedjou

Udensi

et al. 2018

Environmental Toxicology

134

View full text Add to dashboard Cite

show abstract

“…3 In addition, arsenic exposure through drinking water is associated with cardiovascular and neurological disorders and recently with diabetes mellitus. 1,4 In water, arsenic is found in two oxidation states, either as As III (arsenite) or As V (arsenate), with As V being more predominant in the oxidizing environment. 5,6 As III is a neutral molecule and can be actively transported into the cell by aquaglyceroporins in zebrafish and humans.…”

Section: Introductionmentioning

confidence: 99%

Pentavalent Arsenate Transport by Zebrafish Phosphate Transporter NaPi-IIb1

et al. 2011

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Arsenate is a pentavalent form of arsenic that shares similar chemical properties to phosphate. It has been shown to be taken up by phosphate transporters in both eukaryotic and prokaryotic microbes such as yeast and Escherichia coli. Recently, the arsenate uptake in vertebrate cells was reported to be facilitated by mammalian type II sodium/phosphate transporter with different affinities. As arsenate is the most common form of arsenic exposure in aquatic system, identifying the uptake pathway of arsenate into aquatic animals is a crucial step in the elucidation of the entire metabolic pathway of arsenic. In this study, the ability of a zebrafish phosphate transporter, NaPi-IIb1 (SLC34a2a), to transport arsenate was examined. Our results demonstrate that a type II phosphate transporter in zebrafish, NaPi-IIb1, can transport arsenate in vitro when expressed in Xenopus laevis oocytes. NaPi-IIb1 mediates a high-affinity arsenate transport, with a K(m) of 0.22 mM. The natural substrate of NaPi-IIb1, dibasic phosphate, inhibits arsenate transport. Arsenate transport via NaPi-IIb1 is coupled with Na(+) and exhibits sigmoidal kinetics with a Hill coefficient of 3.24 ± 0.19. Consistent with these in vitro studies, significant arsenate accumulation is observed in all examined zebrafish tissues where NaPi-IIb1 is expressed, particularly intestine, kidney, and eye, indicating that zebrafish NaPi-IIb1 is likely the transport protein that is responsible for arsenic accumulation in vivo.

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“…On the other hand, in studies conducted in non-exposed populations (without evidence of exposure to iAs or another toxin), the A140D polymorphism has been associated with higher risk of diVerent diseases, such as childhood acute lymphatic leukemia (Pongstaporn et al 2009) and COPD (Yanbaeva et al 2009), suggesting that GSTO1-1 plays an important role in physiological processes that are not only related to the metabolism of toxins. As is known, human exposure to iAs in drinking water is associated with the development of diverse diseases including diVerent types of cancer, as well as non-cancerous diseases including atherosclerosis, high blood pressure, diabetes, and neurodegenerative diseases De Vizcaya-Ruiz et al 2009;Tseng 2008), all of them sharing a common sub-adjacent inXammatory component. Due the documented participation of GSTO1-1 in iAs metabolism, as well as in inXammation and apoptosis, the main aim of this work was to determine whether the presence of the polymorphisms (A140D, E155del and E208K) of GSTO1-1 in a human population chronically exposed to iAs in drinking water is associated with the expression of genes involved in the inXammatory response and in the apoptotic process, which could contribute to explain the interindividual variation in As-exposed human populations.…”

Section: Discussionmentioning

confidence: 99%

Association of glutathione S-transferase Ω 1-1 polymorphisms (A140D and E208K) with the expression of interleukin-8 (IL-8), transforming growth factor beta (TGF-β), and apoptotic protease-activating factor 1 (Apaf-1) in humans chronically exposed to arsenic in drinking water

et al. 2012

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Human exposure to arsenicals is associated with inflammatory-related diseases including different kinds of cancer as well as non-cancerous diseases like neuro-degenerative diseases, atherosclerosis, hypertension, and diabetes. Interindividual susceptibility has been mainly addressed by evaluating the role of genetic polymorphism in metabolic enzymes in inorganic arsenic (iAs) metabolism. Glutathione S-transferase omega 1-1 (GSTO1-1), which had been associated with iAs metabolism, is also known to participate in inflammatory and apoptotic cellular responses. The polymorphism A140D of GSTO1-1 has been not only associated with distinct urinary profile of arsenic metabolites in populations chronically exposed to iAs in drinking water, but also with higher risk of childhood leukemia and lung disease in non-exposed populations, suggesting that GSTO1-1 involvement in other physiologic processes different from toxics metabolism could be more relevant than is thought. We evaluated the association of the presence of A140D and E208K polymorphisms of GSTO1-1 gene with the expression of genes codifying for proteins involved in the inflammatory and apoptotic response in a human population chronically exposed to iAs through drinking water. A140D polymorphism was associated with higher expression of genes codifying for IL-8 and Apaf-1 mainly in heterozygous individuals, while E208K was associated with higher expression of IL-8 and TGF- gene, in both cases, the association was independently of iAs exposure level; however, the exposure to iAs increased slightly but significantly the influence of A140D and E208K polymorphisms on such genes expression. These results suggest an important role of GSTO1-1 in the inflammatory response and the apoptotic process and indicate that A140D and E208K polymorphisms could increase the risk of developing inflammatory and apoptosis-related diseases in As-exposed populations.

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Arsenic Exposure and Diabetes Mellitus in the United States

Cited by 9 publications

References 19 publications

State of the science review of the health effects of inorganic arsenic: Perspectives for future research

State of the science review of the health effects of inorganic arsenic: Perspectives for future research

Pentavalent Arsenate Transport by Zebrafish Phosphate Transporter NaPi-IIb1

Association of glutathione S-transferase Ω 1-1 polymorphisms (A140D and E208K) with the expression of interleukin-8 (IL-8), transforming growth factor beta (TGF-β), and apoptotic protease-activating factor 1 (Apaf-1) in humans chronically exposed to arsenic in drinking water

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