Arsenic exposure and human blood DNA methylation and hydroxymethylation profiles in two diverse populations from Bangladesh and Spain

Domingo‐Relloso, Arce; Bozack, Anne K.; Kiihl, Samara; Rodriguez-Hernandez, Zulema; Rentero-Garrido, Pilar; Casasnovas, José A.; León-Latre, Montserrat; García‐Barrera, Tamara; Gómez‐Ariza, José Luis; Moreno, B.; Cenarro, Ana; Marco, Griselda de; Parvez, Faruque; Siddique, Abu Baker; Shahriar, Hasan; Uddin, Mohammad Nasir; Islam, Tariqul; Navas‐Acien, Ana; Gamble, Mary V.; Téllez-Plaza, María

doi:10.1016/j.envres.2021.112021

Cited by 7 publications

(2 citation statements)

References 75 publications

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“…In the present study, the total arsenic content was measured, including both the highly toxic inorganic forms and the harmless organic forms-which might lead some to question whether the impact of arsenic was underestimated or overestimated. Nevertheless, recent evidence suggests blood arsenic concentration is a better reflection of exposure to inorganic arsenic than urinary arsenic concentration [37], supporting the reliability of our associations within this matrix. Even so, further studies should be conducted to assess the health risks associated with the different forms of arsenic.…”

Section: Discussionsupporting

confidence: 79%

Bioaccumulation of Non-Essential Trace Elements Detected in Women’s Follicular Fluid, Urine, and Plasma Is Associated with Poor Reproductive Outcomes following Single Euploid Embryo Transfer: A Pilot Study

Palomar,

Gonzalez-Martin,

Quiñonero

et al. 2023

IJMS

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This study aims to determine the association of non-essential trace elements present in follicular fluid, plasma, and urine with reproductive outcomes of women undergoing intracytoplasmic sperm injection (ICSI), preimplantation genetic testing for aneuploidies (PGT-A) and single frozen euploid embryo transfer (SET/FET). This single-center, prospective cohort study included sixty women undergoing ICSI with PGT-A and SET/FET between 2018 and 2019. Urine, plasma and follicular fluid samples were collected on the vaginal oocyte retrieval day to simultaneously quantify ten non-essential trace elements (i.e., Ba, Sr, Rb, Sn, Ti, Pb, Cd, Hg, Sb, and As). We found several associations between the levels of these non-essential trace elements and clinical IVF parameters. Specifically, the increased levels of barium in follicular fluid were negatively associated with ovarian function, pre-implantation development and embryo euploidy, while elevated strontium concentrations in this biofluid were negatively associated with impaired blastulation and embryo euploidy. Elevated plasma strontium levels were negatively associated with ovarian function, fertilization and blastulation. Enhanced presence of other trace elements in plasma (i.e., rubidium and arsenic) were associated with a diminished ovarian function and limited the number of recovered oocytes, mature oocytes and zygotes, respectively. Fully adjusted models suggested significantly lower odds of achieving a live birth when increased concentrations of barium and tin were found in urine.

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Section: Discussionsupporting

confidence: 79%

Bioaccumulation of Non-Essential Trace Elements Detected in Women’s Follicular Fluid, Urine, and Plasma Is Associated with Poor Reproductive Outcomes following Single Euploid Embryo Transfer: A Pilot Study

Palomar,

Gonzalez-Martin,

Quiñonero

et al. 2023

IJMS

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“…Wang et al showed that As inhibited the TET-mediated DNA demethylation and subsequently induced the hypermethylation in the promotor region to suppress the antioxidant genes 8-oxoguanine DNA glycosylase ( OGG1 ) and glutathione S-transferase Pi 1 ( GSTP1 ), thus increasing oxidative stress in human bronchial epithelial (HBE) cells in vitro [ 65 ]. In another recent study, Domingo-Relloso et al conducted an epigenome-wide association study (EWAS) to compare the association of different As exposure levels and human blood 5 mc and 5 hmc markers in two diverse populations from the Aragon Workers Health Study (AWHS, Spain) and the Folic Acid and Creatinine Trial (FACT, Bangladesh) [ 66 ]. The effect of As on site-specific 5 mC and 5 hmC was measured using the Illumina methylation EPIC array on more than 850,000 CpG sites.…”

Section: Arsenic-induced Changes In Dna Methylationmentioning

confidence: 99%

Epigenetic Dysregulations in Arsenic-Induced Carcinogenesis

Islam

Zhao

Wang

et al. 2022

Cancers

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Arsenic is a crucial environmental metalloid whose high toxicity levels negatively impact human health. It poses significant health concerns to millions of people in developed and developing countries such as the USA, Canada, Bangladesh, India, China, and Mexico by enhancing sensitivity to various types of diseases, including cancers. However, how arsenic causes changes in gene expression that results in heinous conditions remains elusive. One of the proposed essential mechanisms that still has seen limited research with regard to causing disease upon arsenic exposure is the dysregulation of epigenetic components. In this review, we have extensively summarized current discoveries in arsenic-induced epigenetic modifications in carcinogenesis and angiogenesis. Importantly, we highlight the possible mechanisms underlying epigenetic reprogramming through arsenic exposure that cause changes in cell signaling and dysfunctions of different epigenetic elements.

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