Arsenic exposure impairs intestinal stromal cells

Kellett, Michael P.; Jatko, Jordan T.; Darling, Caitlin L.; Ventrello, Scott W.; Bain, Lisa J.

doi:10.1016/j.toxlet.2022.03.006

Cited by 10 publications

(1 citation statement)

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“…Recent report showed arsenic treatment impairs distinct population of intestinal stromal cells and intraepithelial and innate immune cells (Kellett et al 2022) (Medina et al 2020). In conjunction, the histology of colon sections of pAs-mice showed infiltration of inflammatory cells and goblet cell hyperplasia.…”

Section: Discussionmentioning

confidence: 99%

Prenatal arsenic exposure stymies gut butyrate production and enhances gut permeability in post natal life even in absence of arsenic deftly through miR122-Occludin pathway

Chakraborty

Gautam

Das

et al. 2022

Preprint

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This discourse attempts to capture a few important dimensions of gut physiology like microbial homeostasis, short chain fatty acid (SCFA) production, occludin expression and gut permeability in post-natal life of mice those received arsenic only during pre-natal life (pAs-mice). The pAs-mice showed a striking reduction in Firmicutes to Bacteroidetes (F/B) ratio coupled with decrease in tight junction protein, occludin resulting in increase in gut permeability, increased infiltration of inflammatory cells in the colon and decrease in common SCFAs in which butyrate reduction was quite prominent in fecal samples as compared to normal control. The above phenotypes of pAs-mice were mostly reversed by supplementing butyrate with food. The talismanic ability of butyrate in enhancing occludin expression, in particular, was dissected further. As miR122 causes degradation of Occludin mRNA, we transiently overexpressed miR122 by injecting appropriate plasmids and showed reversal of butyrate effects in pAs-mice. Thus, pre-natal arsenic exposure orchestrates variety of effects by decreasing in butyrate in pAs-mice leading to increased permeability due to reduced occludin expression. Our research adds a new dimension to our understanding that pre-natal arsenic exposure imprints in post-natal life while there was no further arsenic exposure.

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Section: Discussionmentioning

confidence: 99%