Arsenic exposure increases maternal but not cord serum Ig<scp>G</scp> in <scp>B</scp>angladesh

Ser, Ping Han; Banu, Bilkis; Jebunnesa, Fatema; Fatema, Kaneez; Rosy, Nasrin; Yasmin, Rabeya; Furusawa, Hana; Ali, Liaquat; Shojaei, Ahmad; Watanabe, Chiho

doi:10.1111/ped.12396

Cited by 14 publications

(12 citation statements)

References 36 publications

(73 reference statements)

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“…A case-control study nested within a prospective cohort in Bangladesh also observed that arsenic exposure potentially modulates humoral immunity regarding viral infection, as higher urinary arsenic was associated with increased susceptibility to hepatitis E viral infection among pregnant women [74]. In contrast to our results, multiple studies have observed positive associations between arsenic exposure and antibody profiles [11,12,75,76]. A small cohort study in Bangladesh (n = 60) found that following booster vaccination, children living within a high W-As area had higher diphtheria and tetanus vaccine-related antibody concentrations, but lower blood counts, compared to children living in a low W-As area [12].…”

Section: Discussioncontrasting

confidence: 89%

Evaluating the effects between metal mixtures and serum vaccine antibody concentrations in children: a prospective birth cohort study

et al. 2020

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Background: Many populations are exposed to arsenic, lead, and manganese. These metals influence immune function. We evaluated the association between exposure to single and multiple metals, including arsenic, lead, and manganese, to humoral immunity as measured by antibody concentrations to diphtheria and tetanus toxoid among vaccinated Bangladeshi children. Additionally, we examined if this association was potentially mediated by nutritional status. Methods: Antibody concentrations to diphtheria and tetanus were measured in children's serum at age 5 (n = 502). Household drinking water was sampled to quantify arsenic (W-As) and manganese (W-Mn), whereas lead was measured in blood (B-Pb). Exposure samples were taken during pregnancy, toddlerhood, and early childhood. Multiple linear regression models (MLRs) with single or combined metal predictors were used to determine the association with antibody outcomes. MLR results were transformed to units of percent change in outcome per doubling of exposure to improve interpretability. Structural equation models (SEMs) were used to further assess exposure to metal mixtures. SEMs regressed a latent exposure variable (Metals), informed by all measured metal variables (W-As, W-Mn, and B-Pb), on a latent outcome variable (Antibody), informed by measured antibody variables (diphtheria and tetanus). Weight-forage z-score (WFA) at age 5 was evaluated as a mediator.

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Section: Discussioncontrasting

confidence: 89%

Evaluating the effects between metal mixtures and serum vaccine antibody concentrations in children: a prospective birth cohort study

et al. 2020

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“…64 However, for 1-day-old chickens who were administered metalloid As for up to 60 days in drinking water, the response to Ranikhet disease virus vaccination (administered on days 1 and 60) was suppressed compared with the control group. 52 Considering the ability of As exposure to suppress cell-mediated immune function, it is possible that early-life exposure to As would adversely affect humoral function in offspring.…”

Section: Persistent Organicmentioning

confidence: 96%

Early-life Exposure to Widespread Environmental Toxicants and Health Risk: A Focus on the Immune and Respiratory Systems

Cao

Hylkema

et al. 2016

Annals of Global Health

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Evidence has accumulated that exposure to widespread environmental toxicants, such as heavy metals, persistent organic pollutants, and tobacco smoke adversely affect fetal development and organ maturation, even after birth. The developing immune and respiratory systems are more sensitive to environmental toxicants due to their long-term physical development, starting from the early embryonic stage and persisting into early postnatal life, which requires complex signaling pathways that control proliferation and differentiation of highly heterogeneous cell types. In this review, we summarize the effect of early-life exposure to several widespread environmental toxicants on immune and lung development before and after birth, including the effects on immune cell counts, baseline characteristics of cell-mediated and humoral immunity, and alteration of lung structure and function in offspring. We also review evidence supporting the association between early-life exposure to environmental toxicants and risk for immune-related diseases and lung dysfunction in offspring in later life.

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“…In this study their IgG titers were elevated compared to nonexposed pregnant women from a different region. The study suggest that a higher titer of IgG can increase the pregnant women mortality, however, the overall effect on humoral response that these elevation in IgG can have is still unknown [187].…”

Section: Immunotoxicity Of Metalsmentioning

confidence: 99%