Arsenic in drinking water and renal cancers in rural Bangladesh

Mostafa, Mohammad Golam; Cherry, Nicola

doi:10.1136/oemed-2013-101443

Cited by 34 publications

(31 citation statements)

References 15 publications

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“…Les résultats sont plus contradictoires pour des doses inférieures à 10 microg/L. Une récente étude cas-témoins menée au Banghladesh entre 2008 et 2011 concernant 1489 cas de lésions rénales (dont 90 TVES pyélocalicielles) a mis en évidence un risque majoré de TVES chez les patients buvant de l'eau contaminée par l'arsenic (> 50 microg/L) (niveau de preuve III-2) [55].…”

Section: Maladie Du « Pied Noir » (Black Foot Disease)unclassified

Épidémiologie et facteurs de risque des tumeurs de la voie excrétrice urinaire supérieure : revue de la littérature pour le rapport annuel de l’Association française d’urologie

Ouzzane

Rouprêt

Leon³

et al. 2014

Progrès en Urologie

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Section: Maladie Du « Pied Noir » (Black Foot Disease)unclassified

Épidémiologie et facteurs de risque des tumeurs de la voie excrétrice urinaire supérieure : revue de la littérature pour le rapport annuel de l’Association française d’urologie

Ouzzane

Rouprêt

Leon³

et al. 2014

Progrès en Urologie

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“…Early developmental and adult exposure to arsenic is associated with a multitude of health problems, including cognitive (Rodriguez-Barranco et al, 2013; Rosado et al, 2007; von Ehrenstein et al, 2007; Wasserman et al, 2004), cardiovascular (McClintock et al, 2014; Moon et al, 2012; Wu et al, 2014), metabolic (Chen et al, 2009; Joshi and Shrestha, 2010; Lu et al, 2014) and metastatic (Ferreccio et al, 2013; Mostafa and Cherry, 2013; Wong et al, 1998; Xie et al, 2014) disorders that are manifested across the lifespan. The developmental origins of health and disease (DOHaD) theory (Gluckman et al, 2007; McMullen and Mostyn, 2009; Wadhwa et al, 2009) proposes that susceptibilities to chronic diseases are, in part, determined by physiologic changes initiated in utero in response to an altered prenatal environment.…”

Section: Introductionmentioning

confidence: 99%

Prenatal arsenic exposure alters the programming of the glucocorticoid signaling system during embryonic development

Caldwell

Labrecque

Solomon

et al. 2015

Neurotoxicology and Teratology

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The glucocorticoid system, which plays a critical role in a host of cellular functions including mood disorders and learning and memory, has been reported to be disrupted by arsenic. In previous work we have developed and characterized a prenatal moderate arsenic exposure (50 ppb) model and identified several deficits in learning and memory and mood disorders, as well as alterations within the glucocorticoid receptor signaling system in the adolescent mouse. In these present studies we assessed the effects of arsenic on the glucocorticoid receptor (GR) pathway in both the placenta and the fetal brain in response at two critical periods, embryonic days 14 and 18. The focus of these studies was on the 11β-hydroxysteroid dehydrogenase enzymes (11β-HSD1 and 11β-HSD2) which play a key role in glucorticoid synthesis, as well as the expression and set point of the GR negative feedback regulation. Negative feedback regulation is established early in development. At E14 we found arsenic exposure significantly decreased expression of both protein and message in brain of GR and the 11β-HSD1, while 11β-HSD2 enzyme protein levels were increased but mRNA levels were decreased in the brain. These changes in brain protein continued into the E18 time point, but mRNA levels were no longer significantly altered. Placental HSD11B2 mRNA was not altered by arsenic treatment but protein levels were elevated at E14. GR placental protein levels were decreased at E18 in the arsenic exposed condition. This suggests that arsenic exposure may alter GR expression levels as a consequence of a prolonged developmental imbalance between 11β-HSD1 and 11β-HSD2 protein expression despite decreased 11HSDB2 mRNA. The suppression of GR and the failure to turn down 11β-HSD2 protein expression during fetal development may lead to an altered set point for GR signaling throughout adulthood. To our knowledge, these studies are the first to demonstrate that gestational exposure to moderate levels of arsenic results in altered fetal programming of the glucocorticoid system.

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“…Arsenic is a known carcinogen and has the potential to produce cancers at multiple sites, notably in the skin, bladder, kidneys, prostate, and lungs [56][57][58]. In Bangladesh, skin cancer, lung cancer, and renal cancer have been reported in different studies [12,72,73]. However, skin cancers were more common and the types of skin cancers are squamous cell cancer and basal cell cancer.…”

Section: Suspected Case Showing Melanosis or Keratosis After Excludinmentioning

confidence: 99%

Ground Water Arsenic Contamination and Its Health Effects in Bangladesh

Shojaei

Khan

2015

Handbook of Arsenic Toxicology

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Arsenic in drinking water and renal cancers in rural Bangladesh

Abstract: The relationship between arsenic concentration and both RCC and TCC suggests that arsenic is a causal factor in renal cancer.

Cited by 34 publications

References 15 publications

Épidémiologie et facteurs de risque des tumeurs de la voie excrétrice urinaire supérieure : revue de la littérature pour le rapport annuel de l’Association française d’urologie

Épidémiologie et facteurs de risque des tumeurs de la voie excrétrice urinaire supérieure : revue de la littérature pour le rapport annuel de l’Association française d’urologie

Prenatal arsenic exposure alters the programming of the glucocorticoid signaling system during embryonic development

Ground Water Arsenic Contamination and Its Health Effects in Bangladesh

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