Arsenic in drinking water and cerebrovascular disease, diabetes mellitus, and kidney disease in Michigan: a standardized mortality ratio analysis

Meliker, Jaymie R.; Wahl, Robert; Cameron, Lorraine; Nriagu, Jerome O.

doi:10.1186/1476-069x-6-4

Cited by 258 publications

(184 citation statements)

References 49 publications

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“…The environmental sources of arsenic include groundwater, pesticides (which cause food contamination), seafood, folk or alternative remedies, and products which are used for wood preservation [13]. High drinking water arsenic levels have been associated with an increased mortality from CKD [14]. Arsenic is also a known carcinogen [15].…”

Section: Resultsmentioning

confidence: 99%

Blood Arsenic and Cadmium Concentrations in End-Stage Renal Disease Patients who were on Maintenance Haemodialysis

Palaneeswari

Pm²,

Silambanan³

et al. 2013

JCDR

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Background: In India, there is a rising burden of chronic diseases like hypertension and diabetes. It has been estimated that 25-40% of these patients are likely to develop chronic kidney disease (CKD), with a significant percentage requiring renal replacement therapy. Haemodialysis is the most common method which is used to treat advanced and permanent kidney failure. Derangements in the metabolism of several toxic and trace elements such as antimony, arsenic cadmium, molybdenum, nickel, and selenium have been reported for several decades in patients with chronically reduced renal functions. Overall, the available literature suggests that the blood levels of some elements such as cadmium, chromium, fluorine, iodine, lead, or vanadium are high in end-stage renal disease (ESRD). Aim and Objectives:Our aim was to study the levels of blood arsenic and cadmium in ESRD patients who were on maintenance haemodialysis (MHD), and to study whether there was any relationship between their concentrations and the duration of the MHD. Methods:The blood lead levels were determined in 50 healthy subjects with normal renal functions and in 50 patients with ESRD, who were on MHD. None of them had any history of smoking or any industrial exposure. Results:The results of the study revealed that the blood arsenic and cadmium concentrations were higher in the ESRD patients who were on MHD than in the healthy adults. The blood arsenic and cadmium concentrations were found to increase with the duration of the MHD. Conclusion:The mild increase in the blood arsenic and cadmium concentrations, with an increase in the duration of the MHD in the study population, may be viewed in the wider context, that a prolonged exposure to arsenic and cadmium, even at low levels, may result in renal damage and/or progression of an already existing CKD.

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Section: Resultsmentioning

confidence: 99%

Blood Arsenic and Cadmium Concentrations in End-Stage Renal Disease Patients who were on Maintenance Haemodialysis

Palaneeswari

Pm²,

Silambanan³

et al. 2013

JCDR

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“…The World Health Organization and the United States Environmental Protection Agency have set the drinking water standard for arsenic at 10 parts per billion (ppb) based on cancer risk. However, even at this low level, arsenic may increase the occurrence of cardiovascular disease in humans (1)(2)(3) and promotes angiogenesis and vascular remodeling in mice (4,5). Epidemiological studies demonstrate that arsenic increases risk for many vascular pathologies, including peripheral vascular disease, ischemic heart disease, acute myocardial infarction, atherosclerosis, and hypertension (2,(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Arsenic-stimulated liver sinusoidal capillarization in mice requires NADPH oxidase–generated superoxide

Straub

Clark²,

Ross³

et al. 2008

J. Clin. Invest.

107

114

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Environmental arsenic exposure, through drinking contaminated water, is a significant risk factor for developing vascular diseases and is associated with liver portal hypertension, vascular shunting, and portal fibrosis through unknown mechanisms. We found that the addition of low doses of arsenite to the drinking water of mice resulted in marked pathologic remodeling in liver sinusoidal endothelial cells (SECs), including SEC defenestration, capillarization, increased junctional PECAM-1 expression, protein nitration, and decreased liver clearance of modified albumin. Furthermore, the pathologic changes observed after in vivo exposure were recapitulated in isolated mouse SECs exposed to arsenic in culture. To investigate the role of NADPH oxidase-generated ROS in this remodeling, we examined the effect of arsenite in the drinking water of mice deficient for the p47 subunit of the NADPH oxidase and found that knockout mice were protected from arsenite-induced capillarization and protein nitration. Furthermore, ex vivo arsenic exposure increased SEC superoxide generation, and this effect was inhibited by addition of a Nox2 inhibitor and quenched by the cellpermeant superoxide scavenger. In addition, inhibiting either oxidant generation or Rac1-GTPase blocked ex vivo arsenic-stimulated SEC differentiation and dysfunction. Our data indicate that a Nox2-based oxidase is required for SEC capillarization and that it may play a central role in vessel remodeling following environmentally relevant arsenic exposures.

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“…The average As concentration in marine waters is around 1.5 μg/L (Cullen and Reimer, 1989). While concentrations of As vary in freshwaters, depending on the geological features and the result of As mobilization through a combination of natural processes as well as through a range of anthropogenic activities (Smedley and Kinniburgh, 2002), As-contaminated water is causing worldwide drinking water safety and food supply problems as around 150 million people are exposed to As-contaminated drinking water, particularly in South or Southeast Asia (Brammer and Ravenscroft, 2009;Christen, 2001;Meliker et al, 2007;Pan et al, 2014). In addition to drinking water, As biomagnification by alga, fishes, and other aquatic organisms also introduces As into the food chain and can be a potential source of threat to human health (Maher et al, 2011;Rahman et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Arsenic methylation by an arsenite S-adenosylmethionine methyltransferase from Spirulina platensis

Guo

Xue

Yan

et al. 2016

Journal of Environmental Sciences

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Arsenic-contaminated water is a serious hazard for human health. Plankton plays a critical role in the fate and toxicity of arsenic in water by accumulation and biotransformation.Spirulina platensis (S. platensis), a typical plankton, is often used as a supplement or feed for pharmacy and aquiculture, and may introduce arsenic into the food chain, resulting in a risk to human health. However, there are few studies about how S. platensis biotransforms arsenic. In this study, we investigated arsenic biotransformation by S. platensis. When exposed to arsenite (As(III)), S. platensis accumulated arsenic up to 4.1 mg/kg dry weight.After exposure to As(III), arsenate (As(V)) was the predominant species making up 64% to 86% of the total arsenic. Monomethylarsenate (MMA(V)) and dimethylarsenate (DMA(V)) were also detected. An arsenite S-adenosylmethionine methyltransferase from S. platensis (SpArsM) was identified and characterized. SpArsM showed low identity with other reported ArsM enzymes. The Escherichia coli AW3110 bearing SparsM gene resulted in As(III) methylation and conferring resistance to As(III). The in vitro assay showed that SpArsM exhibited As(III) methylation activity. DMA(V) and a small amount of MMA(V) were detected in the reaction system within 0.5 hr. A truncated SpArsM derivative lacking the last 34 residues still had the ability to methylate As(III). The three single mutants of SpArsM (C59S, C186S, and C238S) abolished the capability of As(III) methylation, suggesting the three cysteine residues are involved in catalysis. We propose that SpArsM is responsible for As methylation and detoxification of As(III) and may contribute to As biogeochemistry.

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Arsenic in drinking water and cerebrovascular disease, diabetes mellitus, and kidney disease in Michigan: a standardized mortality ratio analysis

Cited by 258 publications

References 49 publications

Blood Arsenic and Cadmium Concentrations in End-Stage Renal Disease Patients who were on Maintenance Haemodialysis

Blood Arsenic and Cadmium Concentrations in End-Stage Renal Disease Patients who were on Maintenance Haemodialysis

Arsenic-stimulated liver sinusoidal capillarization in mice requires NADPH oxidase–generated superoxide

Arsenic methylation by an arsenite S-adenosylmethionine methyltransferase from Spirulina platensis

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