Arsenic in Drinking Water and Adverse Pregnancy Outcome in an Arseniasis-Endemic Area in Northeastern Taiwan

Yang, Ching-Yao; Chuang, Hung-Yi; Ho, Christine; Wu, T N; Wu, Ming-Tsang

doi:10.1097/00001648-200309001-00311

Cited by 19 publications

(25 citation statements)

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“…The two studies that examined birth weight as a continuous variable both reported a decrease in mean birth weight (ranging from −29 to −57 g) associated with living in an area with historically high drinking water arsenic levels 12 13. No information on arsenic exposure levels was available, however.…”

Section: Discussionmentioning

confidence: 99%

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Maternal drinking water arsenic exposure and perinatal outcomes in Inner Mongolia, China

Myers

Lobdell

Liu³

et al. 2009

Journal of Epidemiology & Community Health

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Section: Discussionmentioning

confidence: 99%

“…The majority of these studies have focused on arsenic exposure in regions of the world where high levels of arsenic are found in drinking water. Arsenic exposure was associated with lower birth weight in Chile12 and Taiwan13 and higher risks of spontaneous abortion, stillbirth, preterm birth and neonatal death in Bangladesh and India 14–17…”

mentioning

confidence: 99%

Maternal drinking water arsenic exposure and perinatal outcomes in Inner Mongolia, China

Myers

Lobdell

Liu³

et al. 2009

Journal of Epidemiology & Community Health

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“…There are also a few studies indicating that infants born to women who drink water with elevated arsenic concentrations during pregnancy have a lower birthweight (Hopenhayn et al, 2003b;Yang et al, 2003;Huyck et al, 2007). Two of the studies, in north-eastern Taiwan (up to 3,600 µg/L; 85 % above 50 µg/L in the drinking water) and northern Chile (average 40 µg/L in the water), showed 30 and 57 g lower birthweights in infants weighing on average 3,133 and 3,398 g, respectively.…”

Section: Effects Of Arsenic On Foetal Developmentmentioning

confidence: 99%

Scientific Opinion on Arsenic in Food

2009

EFSA Journal

880

220

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The EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) assessed the risks to human health related to the presence of arsenic in food. More than 100,000 occurrence data on arsenic in food were considered with approximately 98 % reported as total arsenic. Making a number of assumptions for the contribution of inorganic arsenic to total arsenic, the inorganic arsenic exposure from food and water across 19 European countries, using lower bound and upper bound concentrations, has been estimated to range from 0.13 to 0.56 µg/kg bodyweight (b.w.) per day for average consumers, and from 0.37 to 1.22 µg/kg b.w. per day for 95 th percentile consumers. Dietary exposure to inorganic arsenic for children under three years of age is in general estimated to be from 2 to 3-fold that of adults. The CONTAM Panel concluded that the provisional tolerable weekly intake (PTWI) of 15 µg/kg b.w. established by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) is no longer appropriate as data had shown that inorganic arsenic causes cancer of the lung and urinary bladder in addition to skin, and that a range of adverse effects had been reported at exposures lower than those reviewed by the JECFA. The CONTAM Panel modelled the dose-response data from key for providing consumption information and calculating exposure, the partners of the EFSA project on the "Individual food consumption data and exposure" coordinated by Ghent University (Department of Public Health, University Hospital, Ghent University, Belgium), and RIKILT (Institute of Food Safety, Wageningen, The Netherlands) for the accessibility of the exposure assessment tools. 4 Table of contents shows now the fourth level of subheadings. 5 An error in the interpretation of the total number of the population in the study of Rahman et al. (2006a) was discovered (Table 41). The BMDL was recalculated and as a consequence it was not considered a potential reference point. The text in the opinion, Table 43 and Appendix were revised accordingly. In addition, the header of the "total number of cases" was replaced by "total number of individuals" in Tables 40-42 and the erroneous units were corrected to µg/L in the text below SUMMARYArsenic is a metalloid that occurs in different inorganic and organic forms, which are found in the environment both from natural occurrence and from anthropogenic activity. The inorganic forms of arsenic are more toxic as compared to the organic arsenic but so far most of the occurrence data in food collected in the framework of official food control are still reported as total arsenic without differentiating the various arsenic species. The need for speciation data is evident because several investigations have shown that especially in seafood most of the arsenic is present in organic forms that are less toxic. Consequently, a risk assessment not taking into account the different species but considering total arsenic as being present exclusively as inorganic arsenic would lead to a considerable overestimation of the health risk rel...

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“…As proposed by recent studies, arsenic exposed residents from across the world exhibit reduced foetal growth, lower birth weight, foetal mortality www.jmscr.igmpublication. Yang et al 2003).Novel work conducted by the Waalkes lab has revealed numerous adverse effects of in utero arsenic contact and also has thrown light on the mechanisms relevant to the developmental toxicity of arsenic. They have established that mice exposed transplacentally to inorganic arsenates have transformed levels of manifestation of tumor suppressor genes, oncogenes and stress related genes all over their lives as adults (Waalkes et al 2004).…”

Section: Introductionmentioning

confidence: 99%