Arsenic-induced oxidative stress in reproductive systems

Erkan, Melike; Aydın, Yasemin; Yılmaz, Banu Orta; Yildizbayrak, Nebahat

doi:10.1016/b978-0-12-819092-0.00016-9

Cited by 5 publications

(5 citation statements)

References 60 publications

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“…The study is in line with the report of Erkan et al(41),Renu et al (4), Zubair et al(116), and Zubair et al(119) following arsenic intoxication revealing a significant decline in FSH levels. However, Zhang and Tang(114) reported a non-significant decline in FSH level, which refutes the study findings.…”

supporting

confidence: 92%

“…Male infecundity has been linked to environmental toxicant exposure, which has contributed immensely to infertility in animal and human studies (40)(41)(42) resulting from oxidative stress processes. However, exposure to environmental carcinogenic substances or endocrine disruptors has been significantly associated with infertility and, thus, has a substantial influence on hormones of reproductive function in males, which alters spermatogenesis and impairs glycolytic pathways and impairment of sperm capacitation (4,41,43) resulting from oxidative stress. Medicinal plants have shown significance in the management of reproductive abnormality, which results from their secondary metabolites (44) such as polyphenols, tannins, flavonoids, quercetin, Etc.…”

Section: Discussionmentioning

confidence: 99%

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The impact of Annona muricata and metformin on semen quality and hormonal profile in Arsenic trioxide-induced testicular dysfunction in male Wistar rat

A¹,

C.C²,

K.C³

et al. 2023

Magna Sci. Adv. Res. Rev.

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Male Infertility has been an issue of significant concern affecting an appraised 20-30% of couples worldwide. The study aims to access the hormonal and semen profile following metformin and ethanolic leave extract of Annona muricata (ELAM) on arsenic-induced toxicity in Male Wistar rats. Thirty-male Wistar rats were used in the study, weighing 150-170 grams, and were divided into six groups of five rats each. Group A received 50 mg/kg of arsenic trioxide (As2O3) only. Group B received feed and water ad libitum. Groups C and D received 50mg/kg of As2O3 and were immediately treated with 30 mg/kg of metformin and 500 mg/kg of ELAM. Group E received 500mg/kg of ELAM and treated immediately with As2O3, and group F received 30 mg/kg of metformin and treated immediately with As2O3. Data obtained were subjected to ANOVA followed by post Hoc LSD using SPSS version 25. Semen quality, Testosterone, FSH, LH levels, and gonadal-somatic index were analysed. Values were presented as Mean±SEM and considered significant at p<0.05. The gonadal-somatic index revealed a significant decrease in group D, while groups B, C, E, and F had no significant decrease compared to A. As2O3 treated rats showed impaired sperm motility, morphology, and total sperm count significantly in groups A to B, while groups C, D, E, and F improved sperm motility, morphology, and total sperm count. Testosterone, LH, and FSH showed a significant decline in group A compared to B, except for LH. Groups C, D, E, and F showed a significant increase in testosterone and LH, except group C in FSH. The study concluded that MET and ELAM improved semen quality and hormonal profile, which could be used in the reversing and prevention of male infecundity linked to arsenic trioxide toxicity caused by oxidative stress.

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supporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

The impact of Annona muricata and metformin on semen quality and hormonal profile in Arsenic trioxide-induced testicular dysfunction in male Wistar rat

A¹,

C.C²,

K.C³

et al. 2023

Magna Sci. Adv. Res. Rev.

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“…The physiological and molecular mechanisms by which arsenic causes reproductive toxicity in fish remain largely unknown. Mammalian studies indicate that arsenic-induced oxidative damage in reproductive tissues significantly mediates reproductive toxicity [ 21 , 22 , 23 ]. Mammalian studies also suggest that arsenic is a potent endocrine disruptor and induces reproductive toxicity by disrupting the endocrine axis (hypothalamus–pituitary–gonad (HPG) axis) that regulates reproductive functions [ 16 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Reproductive and Developmental Effects of Sex-Specific Chronic Exposure to Dietary Arsenic in Zebrafish (Danio rerio)

Rachamalla,

Salahinejad,

Kodzhahinchev

et al. 2024

Toxics

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The present study investigated the reproductive and developmental effects of sex-specific chronic exposure to dietary arsenic in zebrafish. Adult zebrafish (Danio rerio) were exposed to environmentally realistic doses of arsenic via diet [0 (control; no added arsenic), 30 (low), 60 (medium), and 100 (high) μg/g dry weight, as arsenite] for 90 days. Following exposure, arsenic-exposed females from each dietary treatment were mated with control males, and similarly, arsenic-exposed males from each dietary treatment were mated with control females. In females, arsenic exposure resulted in a dose-dependent decrease in reproductive performance (fecundity, fertilization success, and hatching success). Moreover, a dose-dependent increase in developmental toxicity (larval deformities and larval mortality) was observed with maternal exposure to arsenic. In contrast, in males, arsenic exposure also induced similar reproductive and developmental toxicity; however, the adverse effects were mainly evident only in the medium and high dietary arsenic treatment groups. We also examined the sex-specific effects of dietary arsenic exposure on the expression of genes that regulate the hypothalamus–pituitary–gonadal–liver (HPG-L) axis in fish. The gene expression results indicated the downregulation of HPG-L axis genes in females irrespective of the arsenic treatment dose; however, the reduced expression of HPG-L axis genes in males was recorded only in the medium and high arsenic treatment groups. These observations suggest that chronic arsenic exposure in either females or males causes reproductive and developmental toxicity in zebrafish. However, these toxic effects are markedly higher in females than in males. Our results also suggest that arsenic can act as an endocrine disruptor and mediate reproductive and developmental toxicity by disrupting the HPG-L axis in zebrafish.

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“…Side effects associated with arsenic doses vary from fatality to cancers of the skin, bladder, liver, and kidney. Arsenic exposure has also contributed significantly to infertility and miscarriages in humans [ 3 , 4 , 5 ]. Findings from several epidemiological studies on menstruation indicate that exposure to heavy metals affects hormone levels in the human system [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Several urinary biomarkers such as acylcarnitines, uridine (a stimulant of energy expenditure and apoptosis), and methyl xanthine have shown an association between arsenic-induced oxidative stress and infertility in men [ 9 ]. Numerous animal and human studies have shown that arsenic exposures induce infertility by altering the levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone and may cause damage to the process of spermatogenesis and oogenesis [ 5 , 9 ]. Decreases in the fusion of egg–sperm [ 9 ], abnormalities in the shape of the sperm [ 6 ], disturbances of sperm capacitation [ 10 ], impairments in the glycolysis pathway [ 11 ], as well as disruptions in lipid and amino acids’ metabolism [ 12 ], are known adverse outcomes of arsenic for the male reproductive system.…”

Section: Introductionmentioning

confidence: 99%

Arsenic, Oxidative Stress and Reproductive System

Zargari

Rahaman

Kazempour

et al. 2022

JoX

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Infertility is a severe medical problem and is considered a serious global public health issue affecting a large proportion of humanity. Oxidative stress is one of the most crucial factors involved in infertility. Recent studies indicate that the overproduction of reactive oxygen species (ROS) or reactive nitrogen species (RNS) may cause damage to the male and female reproductive systems leading to infertility. Low amounts of ROS and RNS are essential for the normal functioning of the male and female reproductive systems, such as sperm motility, acrosome reaction, interactions with oocytes, ovulation, and the maturation of follicles. Environmental factors such as heavy metals can cause reproductive dysfunction in men and women through the overproduction of ROS and RNS. It is suggested that oxidative stress caused by arsenic is associated with male and female reproductive disorders such as through the alteration in sperm counts and motility, decreased sex hormones, dysfunction of the testis and ovary, as well as damage to the processes of spermatogenesis and oogenesis. This review paper highlights the relationship between arsenic-induced oxidative stress and the prevalence of infertility, with detailed explanations of potential underlying mechanisms.

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Arsenic-induced oxidative stress in reproductive systems

Cited by 5 publications

References 60 publications

The impact of Annona muricata and metformin on semen quality and hormonal profile in Arsenic trioxide-induced testicular dysfunction in male Wistar rat

The impact of Annona muricata and metformin on semen quality and hormonal profile in Arsenic trioxide-induced testicular dysfunction in male Wistar rat

Reproductive and Developmental Effects of Sex-Specific Chronic Exposure to Dietary Arsenic in Zebrafish (Danio rerio)

Arsenic, Oxidative Stress and Reproductive System

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