Arsenic-induced toxicity and the protective role of ascorbic acid in mouse testis

Chang, Soo Im; Jin, Bum Ja; Youn, Pilju; Park, Changbo; Park, Jung-Duck; Ryu, Doug-Young

doi:10.1016/j.taap.2006.11.009

Cited by 161 publications

(104 citation statements)

References 44 publications

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“…This could lead later reproductive consequences such as the impairment of spermatogenesis. This can be supported from the fact that the mice that received SA had lower epdidymidis sperm counts compared to the control mice in our previous study (Chang et al, 2007). For other examples, mice that were continuously exposed to arsenic for 35 days showed decreased sperm counts (Pant et al, 2001).…”

Section: Discussionmentioning

confidence: 52%

“…Therefore, these observations suggest that the target of arsenic is not hypothalamus or pituitary but testis. However, according to our previous study, mRNA expression levels of LH receptor in mouse testis were not changed by arsenic treatment (Chang et al, 2007). Thus, it appears that arsenic does not reduce the release of T by reducing the LH binding sites in Leydig cells in mouse testis.…”

Section: Resultsmentioning

confidence: 64%

“…2). Since individual T and LH levels exhibited wide variability, consistent with previous reports (Bartke et al, 1973;Jane-Faucher et al, 1983;Klomberg et al, 2002;Mi et al, 2002;Chang et al, 2007), and did not show normal distribution, we used a non-parametric test to examine the difference between control and arsenic-treated groups.…”

Section: Resultsmentioning

confidence: 64%

“…According to the previous study, if a sample size is small, T levels cannot be statistically significant (Chang et al, 2007). In the study, the sample size was n=10, and it was not enough to obtain significant results.…”

Section: Discussionmentioning

confidence: 95%

“…Although we assayed T level, we failed to show that the hormone level was decreased significantly by arsenite because T levels in mice were extremely variable among individuals (Chang et al, 2007). In the present study, we investigate whether mouse T can be determined if the sample sizes are increased in spite of the individual variation.…”

Section: Introductionmentioning

confidence: 87%

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Decreased Levels of Plasma Testosterone/LH Ratio in Male Mice Exposed to Sodium Arsenite

Chang¹,

Kim²,

Park³

et al. 2010

Biomolecules and Therapeutics

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-While it's been shown that arsenic impairs male reproductive function, it remains unclear whether the mechanism involves an effect on testosterone (T) production. We examined plasma T and luteinizing hormone (LH) levels in mice given water containing either 20 or 40 mg/L sodium arsenite (SA). The plasma T levels were lower in SA-treated mice than in controls and correlated well with testicular T levels within individuals. However, SA treatment did not significantly affect plasma LH levels. The ratio of plasma T to LH was reduced by the treatment with 40 mg/L SA. These results suggest arsenic-induced defect in testicular testosterone production in mice.

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Section: Discussionmentioning

confidence: 52%

Section: Resultsmentioning

confidence: 64%

Section: Resultsmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 87%

See 3 more Smart Citations

Decreased Levels of Plasma Testosterone/LH Ratio in Male Mice Exposed to Sodium Arsenite

Chang¹,

Kim²,

Park³

et al. 2010

Biomolecules and Therapeutics

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Arsen und anorganische Arsenverbindungen (mit Ausnahme von Arsenwasserstoff) [MAK Value Documentation in German language, 2014]

2014

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 57. Lieferung, Ausgabe 2014 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Aufnahme, Verteilung, Ausscheidung Metabolismus Erfahrungen beim Menschen Reproduktionstoxizität Genotoxizität Kanzerogenität Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Bewertung

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Arsenic and its Inorganic Compounds (with the Exception of Arsine) [MAK Value Documentation, 2014]

Hartwig

2016

The MAK‐Collection for Occupational Health and Safety

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The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated arsenic and its inorganic compounds, with a special focus on gallium arsenide. Available publications and study reports are described in detail. Arsenic and its inorganic compounds are carcinogenic in humans. From the available studies in workers in the semiconductor industry probably exposed to gallium arsenide, no increased cancer risk can be derived. Carcinogenicity studies with inhalation exposure to gallium arsenide revealed lung tumours, mononuclear leukaemia and benign phaeochromocytomas in the adrenal glands in female rats. In animal studies, increased levels of arsenic in blood were determined after exposure to gallium arsenide. The metabolites are the same as those found after exposure to arsenite and arsenate. Although the bioavailability of gallium arsenide is much lower than that of arsenic trioxide, it cannot be completely neglected. Therefore, the classification of arsenic and its inorganic compounds including gallium arsenide as carcinogenic in man (Carcinogen Category 1) has been retained. In vitro genotoxicity studies with inorganic arsenic(III) compounds yielded mostly positive results in tests for sister chromatid exchange, chromosomal aberrations and micronuclei. In in vivo studies with somatic cells, arsenic(III) compounds induced an increase in DNA strand breaks, chromosomal aberrations and micronuclei. In humans exposed long‐term to arsenic, increased incidences of micronuclei, chromosomal aberrations, sister chromatid exchange and DNA damage were observed. Gallium arsenide was not genotoxic in vitro and in vivo. Gallium arsenide, like arsenic, is systemically available and forms the same metabolites as arsenic and its inorganic compounds. For this reason the suspected germ cell mutagenicity of gallium arsenide cannot be unequivocally excluded. Arsenic and its inorganic compounds including gallium arsenide therefore remain in Category 3A for germ cell mutagens which produce mutagenic effects in somatic cells of mammals in vivo and have been shown to reach the germ cells. No MAK value has been derived and thus also no peak limitation has been established, and classification into one of the Pregnancy Risk Groups is not possible. Skin contact is not expected to contribute significantly to systemic toxicity. Sensitizing effects of arsenic and its inorganic compounds cannot be derived from the available data.

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Arsenic-induced toxicity and the protective role of ascorbic acid in mouse testis

Cited by 161 publications

References 44 publications

Decreased Levels of Plasma Testosterone/LH Ratio in Male Mice Exposed to Sodium Arsenite

Decreased Levels of Plasma Testosterone/LH Ratio in Male Mice Exposed to Sodium Arsenite

Arsen und anorganische Arsenverbindungen (mit Ausnahme von Arsenwasserstoff) [MAK Value Documentation in German language, 2014]

Arsenic and its Inorganic Compounds (with the Exception of Arsine) [MAK Value Documentation, 2014]

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