Arsenic-Loaded Biomimetic Iron Oxide Nanoparticles for Enhanced Ferroptosis-Inducing Therapy of Hepatocellular Carcinoma

Abstract

Hepatocellular carcinoma (HCC) has a poor response to most available systemic therapies due to intrinsic or acquired resistance to apoptosis. Ferroptosis-based therapy is expected to circumvent those limitations. Therefore, the rational design of ferroptosis-based therapies with targeted delivery of ferroptosis inducers for HCC is in need. In this study, we found that arsenic trioxide (ATO) can efficiently induce ferroptosis in HCC cells, and this effect could be reversed by the iron chelator deferoxamine. On this basis, a drug delivery system was constructed to enhance the therapeutic efficacy of ATO by camouflaging ATO-loaded magnetic nanoparticles (Fe 3 O 4 ) with HCC cell membranes, termed AFN@CM. After AFN@CM treatment, glutathione peroxidase 4 was strongly inhibited and intracellular lipid peroxide species were significantly increased in HCC cells. In addition, enhanced ferroptosis and tumor suppression were observed both in vitro and in vivo. The bio-safety of AFN@CM was also demonstrated by the in vivo toxicity evaluation. In addition, benefiting from the cell membrane coating, AFN@CM showed enhanced accumulation at tumor sites and achieved continuous tumor elimination in the mouse model. In conclusion, AFN@CM exhibited satisfactory therapeutic efficacy in the treatment of HCC and provided a desirable ferroptosis-based strategy for safe and reliable HCC therapeutics.

A bio-inspired and switchable H+/OH− ion-channel for room temperature exhaled CO2 chemiresistive sensing

“…The concentration of the interfering gas that we detected was higher than that of human exhaled breath (approximately 15 ppb-1.75 ppm), which clearly demonstrates the selectivity of this CSPH ion channel sensor. [51][52][53][54][55][56][57][58][59] The high selectivity of the CSPH ion channel-based sensor is mainly attributed to the material having two CO 2 binding sites, including the hydroxide ion and the tertiary amines on RhB, which greatly increases the ability to interact with CO 2 . In order to explore the effect of humidity, the CSPH ion channel-based sensor was placed at a relative humidity of 5-70% (RH), and then the response of 1000 ppm CO 2 was measured.…”

Cancer Cell Membrane‐Based Materials for Biomedical Applications

“…In addition, the mFolfirinox platform based on CCM camouflage nanoparticles [116] utilizes CCM to increase reactive oxygen species (ROS) resistance in ROS-based chemotherapy, [122] and arsenic-loaded biomimetic Iron Oxide NPs to improve ferroptosis-inducing therapy of hepatocellular carcinoma. [120] Treatment efficacy is directly influenced by the delivery and release of chemotherapeutic drugs. Magnetic fields, electric fields, temperature, and light are examples of external physical stimuli [154] that can cause the precise release of CCM-NPs medicines.…”

Recent Advance in Solution‐Processed Hole Transporting Materials for Organic Solar Cells

“…In recent years, several solution‐processed TMO HTLs were developed and exhibited good performance in modifying OSCs, suggesting the promising potential of TMO‐based HTLs. [ 15,65–67 ] Overall, the solution‐processed HTL materials from PEDOT:PSS, CPEs, and TMOs have significantly enhanced the PCE of OSCs when modifying the transparent electrode, but most solution‐processed HTLs show poor performance in inverted OSCs. Although the underlying reason for the poor performances of solution‐processed HTLs in inverted OSCs is still unclear, it is believed that the WF, conductivity and film quality of these materials are insufficient to realize efficient hole collection while modifying the top electrode.…”