Arsenic Methylation and Bladder Cancer Risk in Case???Control Studies in Argentina and the United States

Steinmaus, Craig; Bates, Michael; Yuan, Yan; Kalman, Dave; Atallah, Raja H.; Rey, Omar A.; Biggs, Mary L.; Hopenhayn, Claudia; Moore, Lee E.; Hoang, Bruce K.; Smith, Allan H.

doi:10.1097/01.jom.0000200982.28276.70

Cited by 159 publications

(102 citation statements)

References 62 publications

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“…It is worth mentioning, however, that MMA has the highest correlation coefficient among the metabolites. MMA excretion has been associated with an increased risk of arsenic-related diseases such as bladder and skin cancer (Hopenhayn-Rich et al, 1996;Chen et al, 2003;Steinmaus et al, 2006). This information supports the hypothesis that arsenic drinking water concentrations are, to some extent, good surrogates of arsenic exposure, even in populations exposed to relatively low levels of arsenic in drinking water (o50 mg/l).…”

Section: Discussionsupporting

confidence: 53%

Urinary arsenic species, toenail arsenic, and arsenic intake estimates in a Michigan population with low levels of arsenic in drinking water

Rivera‐Núñez

Meliker

Meeker

et al. 2011

J Expo Sci Environ Epidemiol

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The large disparity between arsenic concentrations in drinking water and urine remains unexplained. This study aims to evaluate predictors of urinary arsenic in a population exposed to low concentrations (r50 mg/l) of arsenic in drinking water. Urine and drinking water samples were collected from a subsample (n ¼ 343) of a population enrolled in a bladder cancer case-control study in southeastern Michigan. Total arsenic in water and arsenic species in urine were determined using ICP-MS: arsenobetaine (AsB), arsenite ( A separate analysis indicated that AsB and DMA [V] were significantly correlated with fish and shellfish consumption, which may suggest that seafood intake influences DMA[V] excretion. The Spearman correlation between arsenic concentration in toenails and SumAs was 0.36 and between arsenic concentration in toenails and arsenic concentration in water was 0.42. Results show that arsenic exposure from drinking water consumption is an important determinant of urinary arsenic concentrations, even in a population exposed to relatively low levels of arsenic in drinking water, and suggest that seafood intake may influence urinary DMA [V] concentrations.

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Section: Discussionsupporting

confidence: 53%

Urinary arsenic species, toenail arsenic, and arsenic intake estimates in a Michigan population with low levels of arsenic in drinking water

Rivera‐Núñez

Meliker

Meeker

et al. 2011

J Expo Sci Environ Epidemiol

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“…Consequences of arsenic exposure to humans are evident when levels surpass 50 μg l -1 As (the current Argentine drinking water limit) (Bhattacharya et al 2006;Frisbie et al 2005). Health problems observed in the Argentine population are symptomatic of arsenic exposure (Steinmaus et al 2006;Tchounwou et al 2003). The most common manifestation is from skin disorders (lesions, keratosis, hyperpigmentation), but other more chronic conditions have been reported such as cancers (Steinmaus et al 2006;Bates et al 2004;Farías et al 2003;Hopenhayn-Rich et al 1998).…”

Section: Discussionmentioning

confidence: 99%

“…Health problems observed in the Argentine population are symptomatic of arsenic exposure (Steinmaus et al 2006;Tchounwou et al 2003). The most common manifestation is from skin disorders (lesions, keratosis, hyperpigmentation), but other more chronic conditions have been reported such as cancers (Steinmaus et al 2006;Bates et al 2004;Farías et al 2003;Hopenhayn-Rich et al 1998). Remediation and mitigation strategies have been adopted in the provinces.…”

Section: Discussionmentioning

confidence: 99%

Arsenic contamination of natural waters in San Juan and La Pampa, Argentina

O'Reilly

Watts

Shaw

et al. 2010

Environ Geochem Health

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Arsenic (As) speciation in surface and groundwater from two provinces in Argentina (San Juan and La Pampa) was investigated using solid phase extraction (SPE) cartridge methodology with comparison to total arsenic concentrations. A third province, Río Negro, was used as a control to the study. Strong cation exchange (SCX) and strong anion exchange (SAX) cartridges were utilised in series for the separation and preservation of arsenite (As ). Samples were collected from a range of water outlets (rivers/streams, wells, untreated domestic taps, well water treatment works) to assess the relationship between total arsenic and arsenic species, water type and water parameters (pH, conductivity and total dissolved solids, TDS). Analysis of the waters for arsenic (total and species) was performed by inductively coupled plasma mass spectrometry (ICP-MS) in collision cell mode. Total arsenic concentrations in the surface and groundwater from Encon and the San José de Jáchal region of San Juan (north-west Argentina within the Cuyo region) ranged from 9 -357 μg l -1As. Groundwater from Eduardo Castex (EC) and Ingeniero Luiggi (LU) in La Pampa (central Argentina within the Chaco-Pampean Plain) ranged from 3 -1326 μg l -1As. The pH range for the provinces of San Juan (7.2 -9.7) and La Pampa (7.0 -9.9) are in agreement with other published literature. The highest total arsenic concentrations were found in La Pampa well waters (both rural farms and pre-treated urban sources), particularly where there was high pH (typically > 8.2), conductivity (> 2600 μS cm As. Arsenic species for both provinces were predominantly As for groundwater, respectively. This translates to a relative As III abundance of 69 -100 % of the total arsenic in surface waters and 32 -100 % in groundwater. This is unexpected because it is typically thought that in oxidising conditions (surface waters), the dominant arsenic species is As V . However, data from the SPE methodology suggests that As III is the prevalent species in San Juan, indicating a greater influence from reductive processes. La Pampa groundwater had As (equating to up to 33 % of the total arsenic). Previously published literature has focused primarily on the inorganic arsenic species, however this study highlights the potentially significant concentrations of organoarsenicals present in natural waters. The potential for separating and preserving individual arsenic species in the field to avoid transformation during transport to the laboratory, enabling an accurate assessment of in-situ arsenic speciation in water supplies is discussed.

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“…Also, a higher proportion of urinary MA has been associated with higher risks of developing As-related diseases [117][118][119][120][121][122][123].…”

Section: Mechanisms and Toxicity Of Arsenic Compounds Occurring In Sementioning

confidence: 99%

Arsenic in the human food chain, biotransformation and toxicology – Review focusing on seafood arsenic

Molin

Ulven

Meltzer

et al. 2015

Journal of Trace Elements in Medicine and Biology

196

105

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Arsenic Methylation and Bladder Cancer Risk in Case???Control Studies in Argentina and the United States

Abstract: Overall, these results are consistent with data from Taiwan suggesting that some individuals who excrete a higher proportion of ingested arsenic as MMA are more susceptible to arsenic-related cancer.

Cited by 159 publications

References 62 publications

Urinary arsenic species, toenail arsenic, and arsenic intake estimates in a Michigan population with low levels of arsenic in drinking water

Urinary arsenic species, toenail arsenic, and arsenic intake estimates in a Michigan population with low levels of arsenic in drinking water

Arsenic contamination of natural waters in San Juan and La Pampa, Argentina

Arsenic in the human food chain, biotransformation and toxicology – Review focusing on seafood arsenic

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