Arsenic methylation capacity and obesity are associated with insulin resistance in obese children and adolescents

Lin, Hsiu Chen; Huang, Yung Kai; Shiue, Horng Sheng; Chen, Liang Sien; Choy, Cheuk Sing; Huang, Shih Wei; Han, Bor-Cheng; Hsueh, Yu Mei

doi:10.1016/j.fct.2014.08.018

Cited by 31 publications

(15 citation statements)

References 49 publications

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“…In this study, we have shown that elementary school students had a more efficient arsenic methylation capacity (higher DMA% and lower iAs%) than junior high school students; these results were similar to our previous study 13,14 . One interesting finding was that high HOMA-IR values were significantly associated with an increased depression and anger score in junior high school students and all students.…”

Section: Discussionsupporting

confidence: 92%

The Methylation Capacity of Arsenic and Insulin Resistance are Associated with Psychological Characteristics in Children and Adolescents

Lin

Shiue

et al. 2017

Sci Rep

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The goal of the present study was to compare the influence of the methylation capacity of arsenic, as well as insulin resistance on psychological characteristics of school students from elementary and junior high school. 296 elementary and 318 junior high school students participated in health examinations, completed questionnaires and determined their concentrations of urinary arsenic species and psychological characteristics. Insulin resistance was determined by means of the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). We found that HOMA-IR values were significantly related to increased score of the depression and anger after adjusted for age, gender, schools, father’s educational levels, mother’s educational levels, BMI, body fat, and urinary creatinine in all students. Anxiety scores and depression scores of junior high school children were significantly higher compared to elementary school children, but lower in disruptive behavior scores. HOMA-IR levels were significantly inversely related to self-concept scores in junior high school students. A greater urinary inorganic arsenic percentage (iAs%) was marginally significantly related to a higher depression score in junior high school students. This is the first study to show a relationship between HOMA-IR levels or urinary arsenic profiles and psychological distress in school students from elementary and junior high school.

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Section: Discussionsupporting

confidence: 92%

The Methylation Capacity of Arsenic and Insulin Resistance are Associated with Psychological Characteristics in Children and Adolescents

Lin

Shiue

et al. 2017

Sci Rep

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“…The median age of this population was 15 years and their median total urinary arsenic was 7.01μg/L. Compared to the study by Lin et al, where a positive association was found between arsenic and insulin resistance in children (Lin et al, 2014), this NHANES population was a bit older (15 years in this study vs. 8.8 years in Lin et al's), but exposed to much lower levels of arsenic (mean total urinary arsenic of 12.7 μg/L in this study vs. 24.5 μg/L in Lin et al's ). The inconsistency between our findings and Lin et al's may imply a potentially non-linear dose-response relationship between arsenic and insulin resistance.…”

Section: Discussioncontrasting

confidence: 52%

“…If arsenic indeed leads to diabetes through insulin resistance, we may be able to detect an association among younger populations but not in middle-aged adults because those who survive to middle age diabetes-free may be intrinsically resistant to arsenic's effects. A recent study among Taiwanese children seems to support this idea, but exposure levels in that study were relatively high (Lin et al, 2014). Whether arsenic exposure at levels common in the US increases insulin resistance in adolescents is unknown.…”

Section: Introductionmentioning

confidence: 90%

Urinary arsenic and insulin resistance in US adolescents

Peng

Harlow

Park

2015

International Journal of Hygiene and Environmental Health

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Chronic arsenic exposure has been associated with increased diabetes risk in adults. Insulin resistance (IR) has been proposed as a mechanism of arsenic-related diabetes. Although limited evidence in adults found no association between arsenic and IR, the association in adolescents is largely unknown. We examined the association between urinary arsenic and insulin resistance in US adolescents. Eight hundred thirty five adolescents aged 12-19 years, with complete data on urinary arsenic (total arsenic, inorganic arsenic and dimethylarsenic acid (DMA)), fasting glucose, insulin and key covariates were identified from the National Health and Nutrition Examination Survey (NHANES) cycles 2003/2004 through 2009/2010. Generalized additive mixed models accounting for intra-cluster correlation arising from the complex survey design were used to estimate the association between the updated Homeostasis Model Assessment (HOMA2)-IR and each type of arsenic. After adjusting for potential confounders, including urinary creatinine, sociodemographic factors, BMI, waist circumference, and arsenobetaine, arsenic exposure was not associated with HOMA2-IR. Interquartile range increases in total arsenic, inorganic arsenic and DMA were associated with 1.5% (95% CI: -2.0, 5.2), 1.1% (95% CI: -1.5, 3.8) and 0.25% (95% CI: -2.3, 2.9) increases in HOMA2-IR, respectively. In conclusion, despite arsenic's association with diabetes in adults and potential role in insulin resistance, our findings do not support the hypothesis that arsenic exposure at levels common in the US contributes to insulin resistance in adolescents. Whether higher doses and longer exposure duration are required for appreciable influence on insulin resistance, or that arsenic does not act through insulin resistance to induce diabetes needs further investigation.1

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“…In Taiwan, although T2D was not specifically assessed, chronic arsenic exposure and obesity were reported to synergistically contribute to insulin resistance in children (Lin et al 2014). In Bangladesh, some evidence of synergy for T2D was seen between arsenic in water and BMIs >25 kg/m 2 , although <10% of subjects had diabetes and <1% were obese (Pan et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Obesity and increased susceptibility to arsenic-related type 2 diabetes in Northern Chile

Castriota

Acevedo

Ferreccio

et al. 2018

Environmental Research

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Background: The prevalence of type 2 diabetes (T2D) has nearly doubled since 1980. Elevated body mass index (BMI) is the leading risk factor for T2D, mediated by inflammation and oxidative stress. Arsenic shares similar pathogenic processes, and may contribute to hyperglycemia and β-cell dysfunction. Objectives: We assessed a unique situation of individuals living in Northern Chile with data on lifetime arsenic exposure to evaluate the relationship between arsenic and T2D, and investigate possible interactions with BMI. Methods: We analyzed data collected from October 2007-December 2010 from an arsenic-cancer case-control study. Information on self-reported weight, height, smoking, diet, and other factors were obtained. Diabetes was defined by self-reported physician-diagnoses or use of hypoglycemic medication. A total of 1053 individuals, 234 diabetics and 819 without known diabetes were included. Results: The T2D odds ratio (OR) for cumulative arsenic exposures of 610–5279 and ≥5280 µg/L-years occurring 40 years or more before interview were 0.97 (95% CI: 0.66–1.43) and 1.53 (95% CI: 1.05–2.23), respectively. Arsenic-associated T2D ORs were greater in subjects with increased BMIs. For example, the ORs for past cumulative exposures ≥5280 µg/L-years was 1.45 (95% CI: 0.74–2.84) in participants with BMIs <25 kg/m2 but 2.64 (95% CI: 1.14–6.11) in those with BMIs ≥30 kg/m2 (synergy index = 2.49, 95% CI: 0.87–7.09). Results were similar when people with cancer were excluded. Conclusions: These findings identify increased odds of T2D with arsenic exposure, which are significantly increased in individuals with excess BMI.

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Arsenic methylation capacity and obesity are associated with insulin resistance in obese children and adolescents

Cited by 31 publications

References 49 publications

The Methylation Capacity of Arsenic and Insulin Resistance are Associated with Psychological Characteristics in Children and Adolescents

The Methylation Capacity of Arsenic and Insulin Resistance are Associated with Psychological Characteristics in Children and Adolescents

Urinary arsenic and insulin resistance in US adolescents

Obesity and increased susceptibility to arsenic-related type 2 diabetes in Northern Chile

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