Arsenic Speciation and Cadmium Determination in Tobacco Leaves, Ash and Smoke

Iwai, Toshiaki; Chiba, Koichi; Narukawa, Tomohiro

doi:10.2116/analsci.32.957

Cited by 17 publications

(11 citation statements)

References 16 publications

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“…Activities of As depend on its oxidoreduction state and methylation as well as its intracellular distribution and molecular association (13). TS contains mainly inorganic arsenate (iAs V ) (26). As undergoes several steps of oxidoreductive methylations by arsenic 3-methyl transferase (AS3MT) using SAM as a source of methyl groups to generate mono-and dimethyl derivatives (13) ( Figure 7J).…”

Section: Metallomic Analysis Reveals Increased Formation Ofmentioning

confidence: 99%

Tobacco smoking induces metabolic reprogramming of renal cell carcinoma

Reigle¹,

Secic²,

Biesiada³

et al. 2021

Journal of Clinical Investigation

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Background. Clear cell renal cell carcinoma (ccRCC) is the most common histologically defined renal cancer. However, it is not a uniform disease and includes several genetic subtypes with different prognosis. ccRCC is also characterized by distinguished metabolic reprogramming. Tobacco smoking (TS) is an established risk factor for ccRCC with unknown effects on tumor pathobiology. Methods. We investigated the landscape of ccRCCs and paired normal kidney tissues (NKTs) using integrated transcriptomic, metabolomic and metallomic approaches in a cohort of never smokers (NS) and long-term current smokers (LTS) Caucasian males. Results. All three Omics domains consistently identified a distinct metabolic subtype of ccRCCs in LTS, characterized by activation of oxidative phosphorylation (OxPhos) coupled with reprogramming of the malate-aspartate shuttle and metabolism of aspartate, glutamate, glutamine and histidine. Cadmium, copper and inorganic arsenic accumulated in LTS tumors showing redistribution among intracellular pools, including relocation of copper into the cytochrome c oxidase complex. Gene expression signature based on the LTS metabolic subtype provided prognostic stratification of The Cancer Genome Atlas (TCGA) ccRCC tumors that was independent from genomic alterations. Conclusions. The work identified the TS related metabolic subtype of ccRCC with vulnerabilities that can be exploited for precision medicine approaches targeting metabolic pathways. The results provided rationale for the development of metabolic biomarkers with diagnostic and prognostic applications using evaluation of OxPhos status. The metallomic analysis revealed the role of disrupted metal homeostasis in ccRCC highlighting the importance of studying effects of metals from e-cigarettes and environmental exposures.

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Section: Metallomic Analysis Reveals Increased Formation Ofmentioning

confidence: 99%

Tobacco smoking induces metabolic reprogramming of renal cell carcinoma

Reigle¹,

Secic²,

Biesiada³

et al. 2021

Journal of Clinical Investigation

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“…AB was found at significant concentrations in Carex praecox Schreb (28% of the extractable As) and P. lanceolata L. (1.2% of the extractable As). The concentrations of six As species (As III , As V , MMA, DMA, TMAO and TMA) determined in tobacco leaves, ash and smoke of 10 kinds of cigarettes made from tobacco sourced from different countries has been assessed 74 .…”

Section: Montezuma Well Through Vents In the Bottom Of This Collapsedmentioning

confidence: 99%

Atomic Spectrometry Update: review of advances in elemental speciation

Clough

Harrington

Hill

et al. 2018

J. Anal. At. Spectrom.

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This is the ninth Atomic Spectrometry Update (ASU) to focus on advances in elemental speciation and covers a period of approximately 12 months from December 2015. This ASU review deals with all aspects of the analytical atomic spectrometry speciation methods developed for: the determination of oxidation states; organometallic compounds; coordination compounds; metal and heteroatom-containing biomolecules, including metalloproteins, proteins, peptides and amino acids; and the use of metal-tagging to facilitate detection via atomic spectrometry. The review does not cover fractionation, which is sometimes termed operationally defined speciation. As with all ASU reviews the focus of the research reviewed includes those methods that incorporate atomic spectrometry as the measurement technique. However, because speciation analysis is inherently focused on the relationship between the metal(loid) atom and the organic moiety it is bound to, or incorporated within, atomic spectrometry alone cannot be the sole analytical approach of interest. For this reason molecular detection techniques are also included where they have provided a complementary approach to speciation analysis. As in previous years, As and Se speciation continues to dominate the current literature, with reports of the speciation of Cr and Hg also increasing, and there are an ever rising number of publications concerning the analysis of 'biomolecules'. Whilst most of this work is still the preserve of the research field some methods are now approaching the robustness and rapidity for use in the clinical setting.

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“…In cereals, such as rice, iAs and di-methylated species are present as a "natural" component. Another contribution that must be taken into account is the As exposure in smokers since tobacco contains iAs [7,9].…”

Section: −mentioning

confidence: 99%

Biomonitoring of arsenic in woodworkers exposed to CCA and evaluation of other non-occupational sources in Uruguay

Bühl

Álvarez

Torre

et al. 2017

International Journal of Occupational and Environmental Health

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In Uruguay wood-impregnation plants use chromated copper arsenate (CCA) as preservative applying good manufacture practices (GMP). This study aims a retrospective evaluation of toxicologically relevant species levels in CCA exposed woodworker's urine (As-U) and an assessment of the effects of work risk factors and non-occupational sources in As-U of workers from a selected plant. From 2014 to 2016, As-U in 212 urine samples (As-U) of 73 woodworkers from six CCA impregnation plants were determined. In one of these plants, 35 workers were interviewed to obtain individual data of work tasks, lifestyles, diet, habits, etc. that may contribute to their overall exposure to Arsenic. Responses were statistically evaluated. Out of the 212 urine samples from 73 woodworkers, 96% showed lower levels of As-U than those established by health regulations (<35μgL). According to their work tasks 34% of 35 surveyed workers showed high exposure risk to As and 29% moderate exposure risk. Although they have lower levels of As-U owing to their personal protective equipment, As-U significantly correlate to work risk factors. Consumption of bottled water could also contribute to As-U levels as a non-occupational source. These results confirm that efforts of Uruguayan authorities to promote GMP were successful and justify the importance and frequency of As-U systematic biomonitoring for occupational risk assessment. A significant accomplishment of this work is that non-occupational sources of As-like bottled water consumption should also be considered in future studies.

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Arsenic Speciation and Cadmium Determination in Tobacco Leaves, Ash and Smoke

Cited by 17 publications

References 16 publications

Tobacco smoking induces metabolic reprogramming of renal cell carcinoma

Tobacco smoking induces metabolic reprogramming of renal cell carcinoma

Atomic Spectrometry Update: review of advances in elemental speciation

Biomonitoring of arsenic in woodworkers exposed to CCA and evaluation of other non-occupational sources in Uruguay

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