Arsenic species excretion after controlled seafood consumption

Heinrich‐Ramm, R.; Mindt-Prüfert, Susanne; Szadkowski, D

doi:10.1016/s0378-4347(01)00443-1

Cited by 60 publications

(42 citation statements)

References 21 publications

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“…In a separate analysis (Table 7), the median percentage of the total arsenic from either arsenobetaine or dimethylarsinic acid for three categories of total urinary arsenic (o20, 20-50, and 450 mg/l) was determined. Arsenobetaine, usually due to seafood ingestion (Heinrich-Ramm et al, 2002), comprised a greater portion of the total urinary arsenic as levels increased and dimethylarsinic acid was the major contributor at lower levels of total urinary arsenic. Inorganic-related arsenic species (arsenic acid, arsenous acid, dimethylarsinic acid, and monomethylarsonic acid) were summed for each participant and percentiles were computed.…”

Section: Resultsmentioning

confidence: 99%

“…These organic forms are found in fish, shellfish, seaweed, and aquatic sediments and are generally much less toxic. These dietary arsenic species are commonly represented by arsenobetaine and, to a lesser extent, by arsenocholine and arsenosugars (Heinrich-Ramm et al, 2002). In addition to the arsenical forms found in marine organisms, mono-and dimethylated pentavalent and trivalent arsenicals are formed from inorganic arsenic in mammals.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Levels of urinary total and speciated arsenic in the US population: National Health and Nutrition Examination Survey 2003–2004

Caldwell

Jones

Verdon

et al. 2008

J Expo Sci Environ Epidemiol

171

110

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Objective: To provide levels of total and speciated urinary arsenic in a representative sample of the US population. Methods: For the first time, total arsenic and seven inorganic and organic arsenic species were measured in the urine of participants (n ¼ 2557) for the [2003][2004] National Health and Nutrition Examination Survey (NHANES). Data were compiled as geometric means and selected percentiles of urinary arsenic concentrations (mg/l) and creatinine-corrected urinary arsenic (mg/g creatinine) for total arsenic, dimethylarsinic acid, arsenobetaine, and a sum of the inorganic related species. Results: Arsenic acid, arsenous acid, arsenocholine, and trimethylarsine oxide were detected in 7.6%, 4.6%, 1.8%, and 0.3% of the participants, respectively (the limits of detection of 0.6-1.2 mg/l). Monomethylarsonic acid was detected in 35% of the overall population. For all participants aged Z6 years, dimethylarsinic acid (geometric mean of 3.71 mg/l) and arsenobetaine (geometric mean of 1.55 mg/l) had the greatest contribution to the total urinary arsenic levels. A relatively greater percentage contribution from arsenobetaine is seen at higher total urinary arsenic levels and from dimethylarsinic acid at lower total urinary arsenic levels. For all participants aged Z6 years, the 95th percentiles for total urinary arsenic and the sum of inorganic-related arsenic (arsenic acid, arsenous acid, dimethylarsinic acid, and monomethylarsonic acid) were 65.4 and 18.9 mg/l, respectively. For total arsenic and dimethylarsinic acid, covariate-adjusted geometric means demonstrated several slight differences due to age, gender, and race/ethnicity. Conclusions: The data reflect relative background contributions of inorganic and seafood-related arsenic exposures in the US population. Arsenobetaine and dimethylarsinic acid are the major arsenic species present with arsenobetaine, accounting for a greater proportion of total arsenic as total arsenic levels increase. Keywords: speciated arsenic, human, urine, biomonitoring, NHANES. IntroductionArsenic is an element that is widely distributed in the earth's surface in small amounts, primarily in its inorganic forms. Anthropomorphic sources of arsenic have included the smelting of mined metals. Inorganic arsenic is used currently as an outdoor wood preservative, in some pesticides, as semiconductor dopant materials, and in certain medicines. General human exposure to inorganic arsenic results from natural amounts consumed in drinking water. However, dietary arsenic may be an important source (NRC, 2001) when drinking water levels are low. Arsenic also forms organic compounds through biological action on inorganic arsenic. These organic forms are found in fish, shellfish, seaweed, and aquatic sediments and are generally much less toxic. These dietary arsenic species are commonly represented by arsenobetaine and, to a lesser extent, by arsenocholine and arsenosugars (Heinrich-Ramm et al., 2002). In addition to the arsenical forms found in marine organisms, mono-and dimethylated pentava...

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Levels of urinary total and speciated arsenic in the US population: National Health and Nutrition Examination Survey 2003–2004

Caldwell

Jones

Verdon

et al. 2008

J Expo Sci Environ Epidemiol

171

110

View full text Add to dashboard Cite

show abstract

“…From studies where humans have ingested seafood and the urinary excretion of arsenicals have been measured, no indications exist for formation of iAs from ingested organoarsenicals [46,49,54,85,93,99,100,143,144]. Scarce data from human seafood studies indicate that a repeated intake of seafood does not result in higher excretion of iAs than that ingested [93,107].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, a careful diet history must be taken and/or seafood consumption should be terminated at least 2-3 days before urine collection when using urinary tAs as a biomarker for iAs exposure [141,142]. Also, intake of arsenosugars and/or arsenolipids ingested with seafood results in increased DMA excretion [99,[143][144][145]. Some studies have used tAs minus AB or the sum DMA+MA+iAs as a biomarker for recent iAs exposure, resulting in misleading results unless a careful dietary history rules out possible organic arsenicals as precursors for urinary DMA.…”

Section: Biomarkers Of Arsenic Exposurementioning

confidence: 99%

Arsenic in the human food chain, biotransformation and toxicology – Review focusing on seafood arsenic

Molin

Ulven

Meltzer

et al. 2015

Journal of Trace Elements in Medicine and Biology

196

105

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“…A study of volunteers who consumed arsenobetaine-rich seafood found high levels of dimethylarsenic in urine using IEC-HG-ICP MS for speciation. [19] Arsenocholine is converted in vitro to arsenobetaine and methylated metabolites. In cultured primary rat hepatocytes or assays containing subcellular fractions prepared from rat liver, arsenobetaine aldehyde is the common intermediate converted to arsenobetaine or to both trimethylarsine oxide and trimethylarsine [20] (Fig.…”

Section: Trimethylarsonium Compoundsmentioning

confidence: 99%

Commonalities in Metabolism of Arsenicals

Adair¹,

Waters²,

Devesa³

et al. 2005

Environ. Chem.

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Abstract. Elucidating the pathway of inorganic arsenic metabolism shows that some of methylated arsenicals formed as intermediates and products are reactive and toxic species. Hence, methylated arsenicals likely mediate at least some of the toxic and carcinogenic effects associated with exposure to arsenic. Trimethylarsonium compounds and arsenosugars are two other classes of arsenicals to which humans are routinely exposed and there is evidence that both classes are metabolized to produce methylated arsenicals. Here, we review evidence for production of methylated metabolism and consider the challenges posed in unraveling a complex web for metabolism of arsenicals in humans.

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Arsenic species excretion after controlled seafood consumption

Cited by 60 publications

References 21 publications

Levels of urinary total and speciated arsenic in the US population: National Health and Nutrition Examination Survey 2003–2004

Levels of urinary total and speciated arsenic in the US population: National Health and Nutrition Examination Survey 2003–2004

Arsenic in the human food chain, biotransformation and toxicology – Review focusing on seafood arsenic

Commonalities in Metabolism of Arsenicals

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