2006
DOI: 10.1182/blood-2006-04-020610
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Arsenic trioxide: a promising novel therapeutic agent for lymphoproliferative and autoimmune syndromes in MRL/lpr mice

Abstract: MRL/lpr mice develop a human lupuslike syndrome and, as in autoimmune lymphoproliferative syndrome (ALPS), massive lymphoproliferation due to inactivation of Fas-mediated apoptosis. Presently, no effective therapy exists for ALPS, and long term, therapies for lupus are hazardous. We show herein that arsenic trioxide (As 2 O 3 ) is able to achieve quasi-total regression of antibody-and cell-mediated manifestations in MRL/lpr mice. As 2 O 3 activated caspases and eliminated the activated T lymphocytes responsibl… Show more

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Cited by 96 publications
(70 citation statements)
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“…A stock solution was prepared extemporaneously, as described above. As 2 O 3 was given 5 d/wk at a dose of 5 mg/g body weight, as described by Bobé et al (17). Control mice received i.p.…”
Section: Animals Cells and Chemicalsmentioning
confidence: 99%
See 1 more Smart Citation
“…A stock solution was prepared extemporaneously, as described above. As 2 O 3 was given 5 d/wk at a dose of 5 mg/g body weight, as described by Bobé et al (17). Control mice received i.p.…”
Section: Animals Cells and Chemicalsmentioning
confidence: 99%
“…This ROS generation appears to be regulated through several pathways, including NADPH oxidase, mitochondrial electron transport chain, and inhibition of antioxidant enzymes (12)(13)(14). The ROS-mediated apoptosis triggered by As 2 O 3 can impact hematological tumor cells; under certain circumstances, it can also affect nontumor cells, such as keratinocytes, fibroblasts, or activated autoimmune lymphocytes (15)(16)(17).…”
mentioning
confidence: 99%
“…Recently, immunomodulatory properties of As 2 O 3 have been described. For instance, As 2 O 3 exerts therapeutic effects on lymphoproliferative and severe autoimmune disorders manifested in MRL/lpr mice (16) and enhances the immune response against myeloma cells or breast cancer cells (17,18).…”
mentioning
confidence: 99%
“…Les souris MRL/lpr ont des atteintes cutanées (Figure 4) [24]. Par ailleurs, chez la souris MRL/lpr, on détecte une forte production de …”
Section: Rôle Curatif Et Préventif Des Pathologies Auto-immunes De L'unclassified