Arsenic Trioxide-Induced Mandibular Osteomyelitis

Lu, Pei-Chen; Wu, Ju‐Hui; Chen, Chun‐Ming; Du, Je‐Kang

doi:10.1016/j.joms.2015.03.053

Cited by 8 publications

(2 citation statements)

References 12 publications

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“…However, some clinical cases reported necrosis of gingiva and alveolar bone following arsen trioxide application, while paraformaldehyde is slow-acting devitalizing agent with some drawbacks which causes irritation to soft tissues. [3][4][5][6] Alternative of devitalizing agents are studied and some of them are derived from herbal extracts which showed potency to be developed as herbal-based devitalizing agent. 7 Combination of jatropha sap, root of sidaguri and mellitin, namely Pulp-Out has been reported to cause pulpal cell death following its application into tooth cavity that showed similar cell death of commercial devitalizing agents.…”

Section: Introductionmentioning

confidence: 99%

Dentin microhardness and porosity of wistar rats teeth following herbal-based devitalizing agent application

Tanumiharja¹,

Mustakim²,

Trilaksana³

et al. 2022

J Dentomaxillofac Sci

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Objective: To evaluate the microhardness and porosity of the dentin of Wistar rats after pulp-out application. Materials and Methods: This was laboratory experimental research with posttest design with control group. Twelve teeth of wistar rats were allocated into 2 groups, the test group and the control group. In the test group, teeth were prepared on the labial surface until half thickness of the dentin, then pulpout was applied to the base of cavity, covered with GIC. On the 7th day, euthanasia and extraction were performed to test the dentin microhardness with Vickers Hardness Tester and dentin porosity with Laser Scanning Microscope (LSM). Results: The mean value of tooth hardness after pulp-out application was 22.23 ± 3.51 HV while the mean value of the control group was 27.70 ± 1.70 HV, with p value = 0.31 at 95% significance level. There was a decrease in tooth hardness of treated sample which was not significantly different compared to the control group. CLSM photo shows white lines on the sample surface as the exposed dentinal tubules with a higher intensity compared to the control group. Conclusion: Pulp-out decreased tooth microhardness and cause porosity of the teeth.

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Section: Introductionmentioning

confidence: 99%

Dentin microhardness and porosity of wistar rats teeth following herbal-based devitalizing agent application

Tanumiharja¹,

Mustakim²,

Trilaksana³

et al. 2022

J Dentomaxillofac Sci

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“…Arsenic trioxide has played an important role in endodontic procedures, particularly for devitalization of inflamed pulp tissue before root canal treatment. However, leakage may generate cytotoxic effects in both gingiva and bone, with severe consequences including osteomyelitis of the jaw 29,30 . Interestingly, such cytotoxic effect can be exploited for the benefit of OM‐related research by using arsenic trioxide as chemical inducer of mandible OM under controlled conditions.…”

Section: Introductionmentioning

confidence: 99%

Local treatment of experimental mandibular osteomyelitis with an injectable biomimetic gentamicin hydrogel using a new rabbit model

et al. 2021

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Mandibular osteomyelitis (OM) is a challenging disease. Our objective was to assess a new OM model in rabbits induced by arsenic trioxide and to assess the efficacy of local treatment of OM using injectable gentamicin‐collagen hydrogels (GNT‐COLL). OM was induced unilaterally by controlled confinement of arsenic trioxide paste to the root canal of lower incisors of rabbits, while OM progression was characterized for 16 weeks. On the other hand, two injectable COLL hydrogels functionalized with GNT were prepared and characterized for physicochemical properties; a simple GNT‐COLL and a nanohydroxyapatite (nHA)‐ loaded hydrogel (GNT‐COLL/nHA). The two hydrogels were evaluated to treat OM model, while a multidose intramuscular GNT solution served as positive control. Outcomes were assessed by standard methods at 4 and 12 weeks post‐surgery. The clinical, radiographical, and histopathological findings provided evidence for the validity of the arsenic‐induced OM. The results demonstrated that a single intra‐lesional injection of the two hydrogels was more suppressive to OM compared to multidose systemic GNT. The composite GNT‐COLL/nHA hydrogel proved to induce early preservation of alveolar bone (ridge) length and higher amount of bone area\total area at 4 weeks (40.53% ± 2.34) followed by GNT‐COLL (32.21% ± 0.72). On the other hand, the positive control group revealed the least ridge length and bone area\total area (26.22% ± 1.32) at 4 weeks. Both hydrogels successfully arrested OM with no signs of recurrence for up to 12 weeks. Therefore, results support the greater advantages of the composite hydrogel as an osteogenic/antibiotic delivery system in OM treatment.

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