Arsenical cancer of skin:Histologic study with special reference to Bowen's disease

Yeh, Shu; How, Shu-Wen; Lin, Chan-Shing

doi:10.1002/1097-0142(196802)21:2<312::aid-cncr2820210222>3.0.co;2-k

Cited by 164 publications

(72 citation statements)

References 18 publications

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“…Furthermore, As-BD lesion is able to transform into invasive SCC, BCC and combined forms of the skin cancer [9,11,76,77]. Arsenic-induced cancers of other internal organs are reported to associate with As-BD lesions [10,11,76]. Individuals with documented As-BD are considered for more aggressive screening for long-term complications, especially the development of malignancies in the lung and urinary bladder [77][78][79][80].…”

Section: Arsenic and Skin Cancermentioning

confidence: 62%

“…Bowen's disease is a carcinoma in situ of the skin, precancerous in nature, and has been well documented as a consequence of arsenical exposure [9][10][11]66]. Clinically, Arsenic-induced Bowen's disease can be distinguished from non-arsenical Bowen's disease by its occurrence loci on sun-protected areas of the body and its multiple and recrudescent lesions [9,11,75].…”

Section: Arsenic and Skin Cancermentioning

confidence: 99%

“…The skin is thought to be perhaps the most sensitive site. Arsenic-induced skin cancers are usually occur on the sun-protected areas with multiple and recrudescent lesions [9][10][11]. This review discusses the pathomechanisms of arsenic skin cancer and the relationship to its characteristic figures.…”

Section: Introductionmentioning

confidence: 99%

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Arsenic Carcinogenesis in the Skin

2006

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SummaryChronic arsenic poisoning is a world public health issue. Long-term exposure to inorganic arsenic (As) from drinking water has been documented to induce cancers in lung, urinary bladder, kidney, liver and skin in a dose-response relationship. Oxidative stress, chromosomal abnormality and altered growth factors are possible modes of action in arsenic carcinogenesis. Arsenic tends to accumulate in the skin. Skin hyperpigmentation and hyperkeratosis have long been known to be the hallmark signs of chronic As exposure. There are significant associations between these dermatological lesions and risk of skin cancer. The most common arsenic-induced skin cancers are Bowen's disease (carcinoma in situ), basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Arsenic-induced Bowen's disease (As-BD) is able to transform into invasive BCC and SCC. Individuals with As-BD are considered for more aggressive cancer screening in the lung and urinary bladder. As-BD provides an excellent model for studying the early stages of chemical carcinogenesis in human beings. Arsenic exposure is associated with G2/M cell cycle arrest and DNA aneuploidy in both cultured keratinocytes and As-BD lesions. These cellular abnormalities relate to the p53 dysfunction induced by arsenic. The characteristic clinical figures of arsenic-induced skin cancer are: (i) occurrence on sun-protected areas of the body; (ii) multiple and recrudescent lesions. Both As and UVB are able to induce skin cancer. Arsenic treatment enhances the cytotoxicity, mutagenicity and clastogenicity of UV in mammalian cells. Both As and UVB induce apoptosis in keratinocytes by caspase-9 and caspase-8 signaling, respectively. Combined UVB and As treatments resulted in the antiproliferative and proapoptotic effects by stimulating both caspase pathways in the keratinocytes. UVB irradiation inhibited mutant p53 and ki-67 expression, as well as increased in the number of apoptotic cells in As-BD lesions which resulted in an inhibitory effect on proliferation. As-UVB interaction provides a reasonable explanation for the rare occurrences of arsenical cancer in the sun-exposed skin. The multiple and recurrent skin lesions are associated with cellular immune dysfunction in chronic arsenism. A decrease in peripheral CD4+ cells was noticed in the inhabitants of arsenic exposure areas. There was a decrease in the number of Langerhans cells in As-BD lesion which results in an impaired immune function on the lesional sites. Since CD4+ cells are the target cell affected by As, the interaction between CD4+ cells and epidermal keratinocytes under As affection might be closely linked to the pathogenesis of multiple occurrence of arsenic-induced skin cancer. In this

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Section: Arsenic and Skin Cancermentioning

confidence: 62%

Section: Arsenic and Skin Cancermentioning

confidence: 99%

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Arsenic Carcinogenesis in the Skin

2006

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“…Bowen's disease is carcinoma in-situ with potential of lateral spread. [1,2] It is clinically found in elderly person as a solitary irregular well-defi ned scaly plaque on sun-exposed part of the body. [3][4][5][6][7].…”

mentioning

confidence: 99%

Multiple Bowen′s disease in chronic arsenicosis

Singha¹

2014

Int J Med Public Health

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“…Bowen's disease is a carcinoma in situ of the skin resulting from UV or arsenical exposure [2,59,62,64]. Clinically, arsenic-induced Bowen's disease is different from classical (UV-induced) Bowen's disease by the its multiplicity and its propensity in sun-spare skins [2,62,65].…”

Section: Hophysiology Of Arsenic Skin Cancersmentioning

confidence: 99%

Mechanisms and Immune Dysregulation in Arsenic Skin Carcinogenesis

Lee

Liao²,

Yu³

2010

JCT

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In this review, we review the pathomechanisms of arsenic skin carcinogenesis and the immune interactions. Arsenic affects innate and adaptive immune responses through CD4+ T cells, monocytes, macrophages, and Langerhans cells. In skin of As-BD, CD4+ T cells undergo selective and differential apoptosis via Fas-FasL interaction. Numbers and dendrites of Langerhans cells are reduced in As-BD lesions. There is a defective homeostasis and aberrant trafficking of Langerhans cells. Such information is essential to understand the molecular mechanism for arsenic carcinogenesis in both skin and in internal organs.

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Arsenical cancer of skin:Histologic study with special reference to Bowen's disease

Cited by 164 publications

References 18 publications

Arsenic Carcinogenesis in the Skin

Arsenic Carcinogenesis in the Skin

Multiple Bowen′s disease in chronic arsenicosis

Mechanisms and Immune Dysregulation in Arsenic Skin Carcinogenesis

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