Arsenolipids show different profiles in muscle tissues of four commercial fish species

Amayo, Kenneth O.; Raab, Andrea; Krupp, Eva M.; Marschall, Talke Anu; Horsfall, Michael; Feldmann, Jörg

doi:10.1016/j.jtemb.2013.11.004

Cited by 37 publications

(41 citation statements)

References 23 publications

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“…Concentrations of AsLipids are higher in pelagic than demersal fish (Lischka et al 2013) and levels of 50–62% have been observed in filet of oily fish (Taleshi et al 2010, Lischka et al 2013). The relative amounts of AsHC and AsFA in fish may depend on the amount of lipophilic As present, with AsHC present in fish with higher AsLipid concentrations (Amayo et al 2014). …”

Section: Sources and Distribution Of Organic As Species In Marine mentioning

confidence: 99%

“…Extraction of AsLipids has been achieved successfully using a number of approaches, often with mixtures of polar and non-polar organic solvents (Amayo et al 2011, Amayo et al 2014, Glabonjat et al 2014, Sele et al 2015). The AsLipids can be extracted effectively from fish using MeOH/dichloromethane (DCM)(Amayo et al 2011, Amayo et al 2014) or MeOH/chloroform (Taleshi et al 2010) mixtures, which recover the polar AsLipid species.…”

Section: Analytical/monitoring Considerationsmentioning

confidence: 99%

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Human exposure to organic arsenic species from seafood

Taylor

Goodale

Raab

et al. 2017

Science of The Total Environment

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393

256

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Seafood, including finfish, shellfish, and seaweed, is the largest contributor to arsenic (As) exposure in many human populations. In contrast to the predominance of inorganic As in water and many terrestrial foods, As in marine-derived foods is present primarily in the form of organic compounds. To date, human exposure and toxicological assessments have focused on inorganic As, while organic As has generally been considered to be non-toxic. However, the high concentrations of organic As in seafood, as well as the often complex As speciation, can lead to complications in assessing As exposure from diet. In this report, we evaluate the presence and distribution of organic As species in seafood, and combined with consumption data, address the current capabilities and needs for determining human exposure to these compounds. The analytical approaches and shortcomings for assessing these compounds are reviewed, with a focus on the best practices for characterization and quantitation. Metabolic pathways and toxicology of two important classes of organic arsenicals, arsenolipids and arsenosugars, are examined, as well as individual variability in absorption of these compounds. Although determining health outcomes or assessing a need for regulatory policies for organic As exposure is premature, the extensive consumption of seafood globally, along with the preliminary toxicological profiles of these compounds and their confounding effect on assessing exposure to inorganic As, suggests further investigations and process-level studies on organic As are needed to fill the current gaps in knowledge.

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Section: Sources and Distribution Of Organic As Species In Marine mentioning

confidence: 99%

Section: Analytical/monitoring Considerationsmentioning

confidence: 99%

Human exposure to organic arsenic species from seafood

Taylor

Goodale

Raab

et al. 2017

Science of The Total Environment

Self Cite

393

256

View full text Add to dashboard Cite

show abstract

“…Although many arsenolipids still are unknown, several structures have been elucidated recently [41][42][43]. Arsenic-containing hydrocarbons seem to dominate in fish species with higher total arsenolipid content (brill and sardine), whereas arsenic-containing fatty acids seems to predominate in fish species with less total arsenolipid content (mackerel and red mullet) [44].…”

mentioning

confidence: 99%

Arsenic in the human food chain, biotransformation and toxicology – Review focusing on seafood arsenic

Molin

Ulven

Meltzer

et al. 2015

Journal of Trace Elements in Medicine and Biology

196

105

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“…According to the United States department of agriculture (USDA), oxygen radical absorbing capacity (ORAC) values 2007, lentils had a higher ORAC value than most of the common fruits and vegetables including apples, blackberries, figs, cherries, pears, oranges, garlic, cabbage, and almonds (2). Lentil seeds are used nowadays in the folk medicine of many ethnicities to treat different illnesses.…”

Section: Discussionmentioning

confidence: 99%

“…Among the heavy metals, due to having potential carcinogenicity in human and its complex metabolism, arsenic is a special pollutant class that can increase hazard to health (2). Also, cellular damage of arsenic are initiated through the generation of free radicals, which cause lipid, protein, and nucleic acid oxidation, and moreover, induce biological complications including carcinogenesis, mutagenesis, aging, and atherosclerosis (3,4).…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Effects of Red Lentil Extract on Sodium Arsenite-induced Oxidative Stress in Rats

Kalantari‬

Houshmand

Hasanvand

et al. 2017

Jundishapur J Nat Pharm Prod

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Background: Arsenic is a potent environmental toxic agent and leads to the development of various hazardous effects on human health. All human populations are exposed to arsenic and its compounds through occupational or environmental processes. Epidemiological studies also suggested that lentils through a numerous biological activities including antioxidant, anticancer, angiotensin-converting enzyme inhibition, as well as reducing blood lipid and the risk of cardiovascular diseases admit protection against chronic diseases. Objectives: The current study aimed at assessing the protective effect of the red lentil extract (RLE) on sodium arsenite (SA) induced oxidative stress in animals. Methods: Twenty-four Wistar male rats were divided into 4 groups. The first group (control group) received normal saline (2 mL/kg) per os for 25 days. Groups 2 -4 were treated with SA (10 mg/kg) per os for 10 days; and the groups 3 and 4 received 100 and 200 mg/kg of RLE per os for 15 days, respectively, after treatment with SA. Results: Results showed that total phenolic content in crude RLE was 50.6 mg catechin equivalent/g of dry weight. In SA treated groups, serum activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and lipid peroxidation (MDA) in the liver increased. Whereas, the activity of superoxide dismutase (SOD) and catalase and the content of sulfhydryl groups (SH-groups) significantly decreased in liver in the intervention group, compared with those of the control group (P < 0.05). Treatment with RLE reduced the serum level of AST, ALT, and ALP and the level of MDA in the liver, while the activity of the antioxidant enzymes and the level of SH-groups increased. Conclusions: It can be concluded that RLE restored the activity of antioxidant enzymes and serum markers in SA-treated rats, probably by scavenging free radicals and reducing oxidative stress as an antioxidant.

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Arsenolipids show different profiles in muscle tissues of four commercial fish species

Cited by 37 publications

References 23 publications

Human exposure to organic arsenic species from seafood

Human exposure to organic arsenic species from seafood

Arsenic in the human food chain, biotransformation and toxicology – Review focusing on seafood arsenic

Ameliorative Effects of Red Lentil Extract on Sodium Arsenite-induced Oxidative Stress in Rats

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