Arteether: A potent plant growth inhibitor from Artemisia annua

Bagchi, G. D.; Jain, D. C.; Kumar, Sushil

doi:10.1016/s0031-9422(97)00126-x

Cited by 39 publications

(22 citation statements)

References 5 publications

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“…Many studies have found that roots are more sensitive to allelochemicals than aerial parts of seedlings (Bagchi et al 1997;Hamdi et al 2001;Parvez et al 2003;Rahman 2006;Punjani et al 2006;Oliveira & Campos 2006;Ercoli et al 2007). The inhibition of root growth and development by allelochemicals can be due to changes in DNA synthesis in cells of apical root meristem, alteration of the mitochondrial metabolism (Abrahim et al 2000) or changes in cell mitotic indices (Dayan et al 1999;Romagni et al 2000;Pires et al 2001;Iganci et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Allelopathic effects of aqueous extracts of Artistolochia esperanzae O.Kuntze on development of Sesamum indicum L. seedlings

et al. 2010

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RESUMO -(Efeitos alelopáticos de extratos aquosos de Aristolochia esperanzae O.Kuntze sobre desenvolvimento de plântulas de Sesumum indicum L.). Aristolochia esperanzae é uma trepadeira que ocorre no cerrado do sudeste do Brasil. Os objetivos deste trabalho foram de identifi car os efeitos dos extratos aquosos de A. esperanzae sobre a germinação, crescimento da raiz e de células do xilema de plântulas de gergelim. Extratos de folhas, caule e raiz foram preparados nas concentrações de 1,5 e 3,0%. Os extratos causaram alterações na germinação e no crescimento das plântulas com inibição maior causada pelos extratos de raízes. Observou-se mudanças morfológicas e decréscimo no crescimento e desenvolvimento das plântulas de gergelim. Os extratos de A. esperanzae causaram uma inibição de até 50% no tamanho das células do xilema das raízes e mudanças na raiz primária e no número de raízes secundárias. Palavras-chave: Papo-de-perú, alelopatia, crescimento de raiz, desenvolvimento de xilema, cerrado ABSTRACT -(Allelopathic effects of aqueous extracts of Aristolochia esperanzae O.Kuntze on development of Sesamum indicum L. seedlings).Aristolochia esperanzae is a climbing plant that occurs in the savanna regions of Brazil. The aim of this work was to identify the effects of aqueous extracts of A. esperanzae on germination, root growth and xylem cell development of sesame seedlings. Leaf and shoot extracts were prepared at concentrations of 1.5 and 3%. Extracts caused marked changes in germination and seedling growth with greatest inhibition produced by root extracts. Morphological changes and decreased growth and development of seedlings were also observed. The extracts of A. esperanzae caused a reduction of 50% in the size of root xylem cells and marked changes in the primary root and in the number of secondary roots.

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Section: Introductionmentioning

confidence: 99%

Allelopathic effects of aqueous extracts of Artistolochia esperanzae O.Kuntze on development of Sesamum indicum L. seedlings

et al. 2010

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“…La artemisina y sus análogos semi-sintéticos han mostrado actividad como inhibidores del crecimiento de plantas (Bagchi et al, 1997), por lo que podrían ser utilizados en agricultura como herbicidas. La capillina obtenida de raíces de A. capillaris mostró actividad inhibidora de la germinación de semillas de mijo, repollo, pensamiento y zanahoria (Yano, 1987).…”

Section: Artemisia Gallicaunclassified

“…De ella se extrae la artemisina, una lactona sesquiterpénica con propiedades antimaláricas, por lo que A. annua ha sido ampliamente utilizada (Klayman, 1985;Bagchi et al, 1997;Tan et al, 1998;). La artemisina ha mostrado actividad fitotóxica (Duke et al, 1987;Luo y Shen, 1987), inhibiendo la germinación y el crecimiento de diferentes mono y dicotiledóneas, tanto cultivos como arvenses (Bagchi et al, 1997). Otros compuestos relacionados con la artemisina, como los ácidos artemisínico y artesúnico, la desoxiartemisina y el artelinato sódi-co también son fitotóxicos, con diferentes grados de actividad (Chen y Leader, 1990;Stiles et al, 1994).…”

Section: Artemisia Gallicaunclassified

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Fitotoxicidad De Aceites Esenciales Y Extractos Acuosos De Plantas Mediterráneas Para El Control De Arvenses

Sancho¹,

Mercedes²

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“…One reason for the success rate with natural products may be the longlasting interaction of coevolving organisms, resulting in structural classes optimized for their respective targets. In malaria, most highly active compounds are plant derived and are thought to have a role in deterring herbivores (e.g., quinine) or to be potent herbicides (e.g., artemisinin) (13)(14)(15)(16). Besides plants and fungi, bacteria, including the soil-dwelling myxobacteria (17,18), are a rich source of biologically active compounds (19)(20)(21)(22)(23).…”

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Antimalarial Activity of the Myxobacterial Macrolide Chlorotonil A

Held

Gebru

Kalesse

et al. 2014

Antimicrob Agents Chemother

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g Myxobacteria are Gram-negative soil-dwelling bacteria belonging to the phylum Proteobacteria. They are a rich source of promising compounds for clinical application, such as epothilones for cancer therapy and several new antibiotics. In the course of a bioactivity screening program of secondary metabolites produced by Sorangium cellulosum strains, the macrolide chlorotonil A was found to exhibit promising antimalarial activity. Subsequently, we evaluated chlorotonil A against Plasmodium falciparum laboratory strains and clinical isolates from Gabon. Chlorotonil A was highly active, with a 50% inhibitory concentration between 4 and 32 nM; additionally, no correlations between the activities of chlorotonil A and artesunate (rho, 0.208) or chloroquine (rho, ؊0.046) were observed. Per os treatment of Plasmodium berghei-infected mice with four doses of as little as 36 mg of chlorotonil A per kg of body weight led to the suppression of parasitemia with no obvious signs of toxicity. Chlorotonil A acts against all stages of intraerythrocytic parasite development, including ring-stage parasites and stage IV to V gametocytes, and it requires only a very short exposure to the parasite to exert its antimalarial action. Conclusively, chlorotonil A has an exceptional and unprecedented profile of action and represents an urgently required novel antimalarial chemical scaffold. Therefore, we propose it as a lead structure for further development as an antimalarial chemotherapeutic.

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Arteether: A potent plant growth inhibitor from Artemisia annua

Cited by 39 publications

References 5 publications

Allelopathic effects of aqueous extracts of Artistolochia esperanzae O.Kuntze on development of Sesamum indicum L. seedlings

Allelopathic effects of aqueous extracts of Artistolochia esperanzae O.Kuntze on development of Sesamum indicum L. seedlings

Fitotoxicidad De Aceites Esenciales Y Extractos Acuosos De Plantas Mediterráneas Para El Control De Arvenses

Antimalarial Activity of the Myxobacterial Macrolide Chlorotonil A

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