Artemin Stimulates Radio- and Chemo-resistance by Promoting TWIST1-BCL-2-dependent Cancer Stem Cell-like Behavior in Mammary Carcinoma Cells

Banerjee, Ansuman; Qian, Pengxu; Wu, Zhengsheng; Ren, Xiaoge; Steiner, Michael; Bougen, Nicola M.; Liu, Suling; Liu, Dong-Xu; Zhu, Tao; Lobie, Peter E.

doi:10.1074/jbc.m112.365163

Cited by 41 publications

(56 citation statements)

References 61 publications

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“…The heterotypic cell adhesion assay was performed as described previously (11). The ALDEFLUOR assay and mammosphere assays were performed as described previously (15).…”

Section: Methodsmentioning

confidence: 99%

“…Depletion of ARTN partially restores tamoxifen sensitivity in ER ϩ tamoxifen-resistant cells (16). Depletion of ARTN also reverses acquired chemo-and/or radio-resistance via depletion of CSC population in ER-mammary carcinoma (15).…”

mentioning

confidence: 97%

“…In addition, ARTN expression in endometrial carcinoma is significantly associated with higher tumor grade and invasiveness (14). ARTN expression decreased sensitivity to paclitaxel in mammary carcinoma (15), both paclitaxel and doxorubicin in endometrial carcinoma (14), and decreased sensitivity to ionizing radiation in mammary carcinoma (15). Furthermore, ARTN also functions to mediate acquired resistance to chemotherapeutics and ionizing radiation in mammary carcinoma by enhancing the cancer stem cell-like (CSC) population (15).…”

mentioning

confidence: 99%

“…ARTN expression decreased sensitivity to paclitaxel in mammary carcinoma (15), both paclitaxel and doxorubicin in endometrial carcinoma (14), and decreased sensitivity to ionizing radiation in mammary carcinoma (15). Furthermore, ARTN also functions to mediate acquired resistance to chemotherapeutics and ionizing radiation in mammary carcinoma by enhancing the cancer stem cell-like (CSC) population (15). In addition, ARTN is an estrogen-inducible gene and mediates acquired antiestrogen (tamoxifen) resistance in mammary carcinoma.…”

mentioning

confidence: 99%

“…HER2-overexpressing cell lines possess a higher level of BCL-2 expression (19), and increased BCL-2 expression has been reported to contribute to the development of trastuzumab resistance (20). Previously, ARTN has also been demonstrated to regulate BCL-2 in mammary carcinoma (15,16) and enhance the CSC population in a BCL-2-dependent manner. Independently, CSCs have also been reported to utilize BCL-2 for survival (21).…”

mentioning

confidence: 99%

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Artemin, a Member of the Glial Cell Line-derived Neurotrophic Factor Family of Ligands, Is HER2-regulated and Mediates Acquired Trastuzumab Resistance by Promoting Cancer Stem Cell-like Behavior in Mammary Carcinoma Cells

Ding

Banerjee

Tan

et al. 2014

Journal of Biological Chemistry

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Background: Artemin is a cancer stem cell (CSC) and metastatic factor in mammary carcinoma. Results: Artemin promotes trastuzumab resistance by enhancing the cancer stem cell-like population in mammary carcinoma. Conclusion: Artemin mediates acquired resistance to trastuzumab in mammary carcinoma. Significance: Functional antagonism of Artemin may enhance trastuzumab sensitivity and reverse acquired resistance to trastuzumab in mammary carcinoma.

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“…The heterotypic cell adhesion assay was performed as described previously (11). The ALDEFLUOR assay and mammosphere assays were performed as described previously (15).…”

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 97%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Artemin, a Member of the Glial Cell Line-derived Neurotrophic Factor Family of Ligands, Is HER2-regulated and Mediates Acquired Trastuzumab Resistance by Promoting Cancer Stem Cell-like Behavior in Mammary Carcinoma Cells

Ding

Banerjee

Tan

et al. 2014

Journal of Biological Chemistry

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The FZD7‐TWIST1 axis is responsible for anoikis resistance and tumorigenesis in ovarian carcinoma

et al. 2019

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Frizzled family receptor 7 ( FZD 7 ), a Wnt signaling receptor, is associated with the maintenance of stem cell properties and cancer progression. FZD 7 has emerged as a potential therapeutic target because it is capable of transducing both canonical and noncanonical Wnt signals. In this study, we investigated the regulatory pathway downstream of FZD 7 and its functional roles. We found that FZD 7 expression was crucial to the maintenance of the mesenchymal phenotype, anoikis resistance, and spheroid and tumor formation in ovarian cancer (OC). We identified TWIST 1 as the crucial downstream effector of the FZD 7 pathway. TWIST 1 , a basic helix loop helix transcription factor, is known to associate with mesenchymal and cancer stem cell phenotypes. Manipulating TWIST 1 expression mimicked the functional consequences observed in the FZD 7 model, and overexpression of TWIST 1 partially rescued the functional phenotypes abolished by FZD 7 knockdown. We further proved that FZD 7 regulated TWIST 1 expression through epigenetic modifications of H3K4me3 and H3K27ac at the TWIST 1 proximal promoter. We also identified that the FZD 7 ‐ TWIST 1 axis regulates the expression of BCL 2 , a gene that controls apoptosis. Identification of this FZD 7 ‐ TWIST 1 ‐ BCL 2 pathway reaffirms the mechanism of anoikis resistance in OC. We subsequently showed that the FZD 7 ‐ TWIST 1 axis can be targeted by using a small molecule inhibitor of porcupine, an enzyme essential for secretion and functional activation of Wnts. In conclusion, our results identified that the FZD 7 ‐ TWIST 1 axis is important for tumorigenesis and anoikis resistance, and therapeutic inhibition results in cell death in OCs.

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Is Mda‐7/IL‐24 a Potential Target and Biomarker for Enhancing Drug Sensitivity in Human Glioma U87 Cell Line?

Wang

Zhu

Yang

2013

The Anatomical Record

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Gliomas are the most common form of primary brain tumor with the highest mortality rates. Drug resistance is a major cause of treatment failure in patients with glioma. Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) has been demonstrated to play an important role in drug resistance in human cancer cell lines. However, the reversing effect of mda-7/IL-24 on drug resistance of human glioma is not fully clear. Here, we investigated the effects of overexpression of the mda-7/IL-24 gene in human glioma. We established a cisplatin-resistant U87 glioma cell line and found that mda-7/IL-24 was highly correlated with drug resistance. Furthermore, we investigated the apoptotic rate, intracellular accumulation of Rhodamine-123, and expression of glutathione and P-glycoprotein. The over-expression of mda-7/IL-24 enhanced cisplatin cytotoxicity and reversal of drug resistance in glioma cells. The reversing effect of mda-7/IL-24 on drug resistance was induced mainly through the regulation of drug resistance-related genes and efflux drug pumps. Thus, mda-7/IL-24 can be used as a promising predictive biomarker and potential therapeutic target for chemotherapy in glioma.

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Artemin Stimulates Radio- and Chemo-resistance by Promoting TWIST1-BCL-2-dependent Cancer Stem Cell-like Behavior in Mammary Carcinoma Cells

Cited by 41 publications

References 61 publications

Artemin, a Member of the Glial Cell Line-derived Neurotrophic Factor Family of Ligands, Is HER2-regulated and Mediates Acquired Trastuzumab Resistance by Promoting Cancer Stem Cell-like Behavior in Mammary Carcinoma Cells

Artemin, a Member of the Glial Cell Line-derived Neurotrophic Factor Family of Ligands, Is HER2-regulated and Mediates Acquired Trastuzumab Resistance by Promoting Cancer Stem Cell-like Behavior in Mammary Carcinoma Cells

The FZD7‐TWIST1 axis is responsible for anoikis resistance and tumorigenesis in ovarian carcinoma

Is Mda‐7/IL‐24 a Potential Target and Biomarker for Enhancing Drug Sensitivity in Human Glioma U87 Cell Line?

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