Artemisia annua essential oil extraction, characterization, and incorporation in nanoliposomes, smart drug delivery systems against Candida species

Risaliti, Laura; Pini, Gian Andrea; Ascrizzi, Roberta; Donato, Rosa; Sacco, Cristiana; Bergonzi, Maria Camilla; Salvatici, Maria Cristina; Bilia, Anna Rita

doi:10.1016/j.jddst.2020.101849

Cited by 25 publications

(21 citation statements)

References 27 publications

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“…Risaliti et al ( 2020 ) incorporated Artemisia annua essential oil (AEO) against Candida species ( C. krusei, C. parapsilosis, C. dubliniensis, C. norvegensis, C. tropicalis , and C. albicans ) in a nanoliposomal formulation (AEOL). Encapsulation efficiency was about 75%, and the recovery percentage was more than 90%.…”

Section: Biomedical Applications Of Nanoliposomesmentioning

confidence: 99%

Insight Into Nanoliposomes as Smart Nanocarriers for Greening the Twenty-First Century Biomedical Settings

Aguilar-Pérez

Avilés-Castrillo

Medina

et al. 2020

Front. Bioeng. Biotechnol.

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The necessity to develop more efficient, biocompatible, patient compliance, and safer treatments in biomedical settings is receiving special attention using nanotechnology as a potential platform to design new drug delivery systems (DDS). Despite the broad range of nanocarrier systems in drug delivery, lack of biocompatibility, poor penetration, low entrapment efficiency, and toxicity are significant challenges that remain to address. Such practices are even more demanding when bioactive agents are intended to be loaded on a nanocarrier system, especially for topical treatment purposes. For the aforesaid reasons, the search for more efficient nano-vesicular systems, such as nanoliposomes, with a high biocompatibility index and controlled releases has increased considerably in the past few decades. Owing to the stratum corneum layer barrier of the skin, the in-practice conventional/conformist drug delivery methods are inefficient, and the effect of the administered therapeutic cues is limited. The current advancement at the nanoscale has transformed the drug delivery sector. Nanoliposomes, as robust nanocarriers, are becoming popular for biomedical applications because of safety, patient compliance, and quick action. Herein, we reviewed state-of-the-art nanoliposomes as a smart and sophisticated drug delivery approach. Following a brief introduction, the drug delivery mechanism of nanoliposomes is discussed with suitable examples for the treatment of numerous diseases with a brief emphasis on fungal infections. The latter half of the work is focused on the applied perspective and clinical translation of nanoliposomes. Furthermore, a detailed overview of clinical applications and future perspectives has been included in this review.

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Section: Biomedical Applications Of Nanoliposomesmentioning

confidence: 99%

Insight Into Nanoliposomes as Smart Nanocarriers for Greening the Twenty-First Century Biomedical Settings

Aguilar-Pérez

Avilés-Castrillo

Medina

et al. 2020

Front. Bioeng. Biotechnol.

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“…75%. The minimum fungicidal concentration of Artemisia annua essential oil loaded in liposomes, ranging 5 to 10 mg/mL, was much inferior than that of free essential oil (Risaliti et al 2020b). Another study investigated the antioxidant, anti-inflammatory and antibacterial properties of Salvia triloba L. and Rosmarinus officinalis L. essential oils formulated in liposomes.…”

Section: Conventional Liposomesmentioning

confidence: 95%

Recent strategies in nanodelivery systems for natural products: a review

Vanti

2021

Environ Chem Lett

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Natural products are major molecules for drug discovery due to their structural diversity and their interaction with various biological targets, yet their clinical application is limited by poor water solubility or low lipophilicity, inappropriate molecular size, low dissolution rate and permeation, instability, high metabolic rate and rapid clearance. These issues can be solved by nanomedicine, by improving bioavailability and therapeutic efficacy. Here we review nanocarriers made of polymer or lipid constituents. Specifically, we describe the technological characteristics of each nanosystem, with examples of application to single natural constituents or plant extracts, and possible routes of administration. We report in vitro and in vivo studies and we conclude with the potential advantages of nanodelivery systems in terms of increased stability and solubility, improved biodistribution and efficacy, reduced adverse effects and toxicity.

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“…By encapsulation, the antimicrobial activity could be improved, while preserving or even increasing their clinical effectiveness. This is mainly due to the subcellular size of the VNs, which could strengthen the passive absorption mechanism and reduce the transport resistance of the substances [ 52 , 53 ].…”

Section: The Entrapment Of Herbal Extracts Into Vesicular Nanosystems...mentioning

confidence: 99%

Vesicular Nanocarriers for Phytocompounds in Wound Care: Preparation and Characterization

2022

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The need to develop wound healing preparations is a pressing challenge given the limitations of the current treatment and the rising prevalence of impaired healing wounds. Although herbal extracts have been used for many years to treat skin disorders, due to their wound healing, anti-inflammatory, antimicrobial, and antioxidant effects, their efficacy can be questionable because of their poor bioavailability and stability issues. Nanotechnology offers an opportunity to revolutionize wound healing therapies by including herbal compounds in nanosystems. Particularly, vesicular nanosystems exhibit beneficial properties, such as biocompatibility, targeted and sustained delivery capacity, and increased phytocompounds’ bioavailability and protection, conferring them a great potential for future applications in wound care. This review summarizes the beneficial effects of phytocompounds in wound healing and emphasizes the advantages of their entrapment in vesicular nanosystems. Different types of lipid nanocarriers are presented (liposomes, niosomes, transferosomes, ethosomes, cubosomes, and their derivates’ systems), highlighting their applications as carriers for phytocompounds in wound care, with the presentation of the state-of-art in this field. The methods of preparation, characterization, and evaluation are also described, underlining the properties that ensure good in vitro and in vivo performance. Finally, future directions of topical systems in which vesicle-bearing herbal extracts or phytocompounds can be incorporated are pointed out, as their development is emerging as a promising strategy.

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Artemisia annua essential oil extraction, characterization, and incorporation in nanoliposomes, smart drug delivery systems against Candida species

Cited by 25 publications

References 27 publications

Insight Into Nanoliposomes as Smart Nanocarriers for Greening the Twenty-First Century Biomedical Settings

Insight Into Nanoliposomes as Smart Nanocarriers for Greening the Twenty-First Century Biomedical Settings

Recent strategies in nanodelivery systems for natural products: a review

Vesicular Nanocarriers for Phytocompounds in Wound Care: Preparation and Characterization

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