Artemisia fukudo essential oil attenuates LPS-induced inflammation by suppressing NF-κB and MAPK activation in RAW 264.7 macrophages

Yoon, Weon‐Jong; Moon, Ji‐Young; Song, Guanhua; Lee, Y.K.; Han, Mi-Jeong; Lee, J.S.; Ihm, Byung-Sun; Lee, W.J.; Lee, N.H.; Hyun, Chang‐Gu

doi:10.1016/j.fct.2010.02.014

Cited by 97 publications

(75 citation statements)

References 30 publications

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“…The result illustrated that the immune system of broilers was over activated, which could result in the redistribution of nutrients away from growth and towards the immune reaction, and eventually led to the decline of the growth performance. Diet supplemented with AOE significantly inhibited the increased content of serum IgA and IgG, which indicated that AOE could weaken the excessive activation of immune system, and alleviate the immune stress, Currently, the effect of AOE on immune function in broilers rarely was reported, but many studies reported that the Artemisia plants could alleviate the inflammatory response induced by LPS, and the present study was corroborated by these research results (Jang et al 2005;Yoon et al 2010;Jang et al 2015).…”

Section: Growth Performancesupporting

confidence: 80%

DietaryArtemisia ordosicaextract alleviating immune stress in broilers exposed to lipopolysaccharide

Zhang

Shi

et al. 2017

Italian Journal of Animal Science

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This study was conducted to investigate the effect of Artemisia ordosica extract (AOE) on broilers challenged with lipopolysaccharide (LPS). 96 one-day-old Arbour Acres broilers were assigned in 2 Â 2 factorial design, including two dietary treatments (0 or 1000 mg/kg AOE) and two immunological challenge (saline or LPS). on d 14, 16, 18 and 20, broilers were injected intra-abdominally with LPS solution (the LPS was dissolved in sterile saline at a concentration of 100 lg/mL) at 500 lg/kg of base weight, or an equivalent amount of sterile saline. Blood samples were collected on d 21 and 28. During LPS-challenged periods (days 15-21), AOE alleviated the compromised average daily gain and average daily feed intake (p < .05) in broilers challenged with LPS. On day 21, the LPS challenge increased (p < .05) serum adrenocorticotropic hormone, corticosterone, interleukin-1, interleukin-2, interleukin-6, immunoglobulin G and immunoglobulin A, decreased (p < .05) the content of serum growth hormone and insulin-like growth factor-1. However, diet supplemented with AOE reduced the elevation of serum corticosterone (p ¼ .054), interleukin-2 (p < .05), immunoglobulin A (p < .05) and immunoglobulin G (p ¼ .079) caused by LPS on day 21. After a week's recovery, on d 28, AOE reduced the serum interleukin-6 content (p < .05). It may be that AOE exert its beneficial effect on broilers challenged with LPS by lessening the inflammatory cytokines and stress hormone, weakening the over activated immune system and finally, improving the growth performance.ARTICLE HISTORY

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Section: Growth Performancesupporting

confidence: 80%

DietaryArtemisia ordosicaextract alleviating immune stress in broilers exposed to lipopolysaccharide

Zhang

Shi

et al. 2017

Italian Journal of Animal Science

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“…A. fukudo is mainly distributed along the shorelines of Jeju Island, South Korea, and have been used as a flavouring agent and cosmetic ingredient in Korea (Abad et al 2012). Previous study reported that A. fukudo possessed essential oils composed of oxygenated monoterpene and sesquiterpene hydrocarbons with anti-inflammatory effect, and confirmed its potential herbal medicinal activity (Yoon et al 2010). Lots of Artemisia species grow together in wild and there is some difficulty to authenticate each species because of their similar morphological traits.…”

Section: Mitogenome Announcementmentioning

confidence: 99%

Complete chloroplast genome sequence of Artemisia fukudo Makino (Asteraceae)

Lee

Park

Kim

et al. 2016

Mitochondrial DNA Part B

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In this study, a complete chloroplast genome sequence of Artemisia fukudo (Asteraceae family) was characterized by de novo assembly using whole genome sequence data. The chloroplast genome was 151,011 bp in length, comprising a large single-copy region of 82,751 bp, a small single copy region of 18,348 bp and a pair of inverted repeats of 24,956 bp. The genome contained 80 protein-coding genes, 4 rRNA genes and 30 tRNA genes. Phylogenetic tree revealed that A. fukudo was closely located in other Artemisia species, Artemisia montana and Artemisia frigida .

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“…Certain studies have indicated that members of the MAPK signaling pathway, including ERK, p38 MAPK and JNK, are important in signal transduction pathways activated by stimuli and mediate a number of physiological and pathological changes in cell function (29). The MAPK pathway is also the signal cascade pathway of pro-inflammatory molecules and regulates the inflammatory response through NF-κB activation (30,31). In order to determine the effect of rhBNP in lung fibroblasts under LPS stimulation, the NF-κB pathway was investigated as it is involved in numerous cellular processes, particularly inflammation (32,33).…”

Section: B Amentioning

confidence: 99%

Recombinant human brain natriuretic peptide attenuates LPS-induced cellular injury in human fetal lung fibroblasts via inhibiting MAPK and NF-κB pathway activation

Song

Zhao

Liu

et al. 2016

Molecular Medicine Reports

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Abstract. Inflammatory responses are vital in lung injury diseases, particularly acute respiratory distress syndrome (ARDS). Recombinant human brain natriuretic peptide (rhBNP) has been shown to exhibit anti-inflammatory effects in vivo in our previous studies. The present study aimed to investigate the mechanisms underlying the anti-inflammatory effects of rhBNP on lipopolysaccharide (LPS)-induced human fetal lung fibroblasts (HFL-1). The results showed that LPS induced a significant increase in the leakage of lactate dehydrogenase and the secretion of interleukin (IL)-1β. Activation of p38, extracellular-signal regulated kinase (ERK) 1/2, c-Jun NH2-terminal kinase (JNK) mitogen-activated protein kinases (MAPK)s, and nuclear factor (NF)-κB in HFL-1 cells was also observed following treatment with LPS. Treatment with rhBNP (0.1 µM) reduced the production of IL-1β at the protein and mRNA levels. Moreover, rhBNP decreased the phosphorylation of p38, ERK1/2 and JNK induced by LPS. However, the JNK inhibitor, SP600125, significantly inhibited LPS-induced IL-1β production. These results indicate that the inhibition of IL-1β by may dependent upon the JNK signaling pathway. The LPS-induced NF-κB activation was also suppressed by rhBNP, and IL-1β production was inhibited by the NF-κB inhibitor. Furthermore, NF-κB activation was attenuated by the JNK inhibitor, indicating that NF-κB activation was dependent on the JNK signaling pathway. The present study suggests that rhBNP exhibits an anti-inflammatory effect on LPS-induced HFL-1 cell injury via the inhibition of MAPK and NF-κB signaling pathways and may exhibit therapeutic potential for acute lung injury and ARDS.

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Artemisia fukudo essential oil attenuates LPS-induced inflammation by suppressing NF-κB and MAPK activation in RAW 264.7 macrophages

Cited by 97 publications

References 30 publications

DietaryArtemisia ordosicaextract alleviating immune stress in broilers exposed to lipopolysaccharide

DietaryArtemisia ordosicaextract alleviating immune stress in broilers exposed to lipopolysaccharide

Complete chloroplast genome sequence of Artemisia fukudo Makino (Asteraceae)

Recombinant human brain natriuretic peptide attenuates LPS-induced cellular injury in human fetal lung fibroblasts via inhibiting MAPK and NF-κB pathway activation

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