Artemisia Iwayomogi Extract Attenuates High-Fat Diet-Induced Hypertriglyceridemia in Mice: Potential Involvement of the Adiponectin-AMPK Pathway and Very Low Density Lipoprotein Assembly in the Liver

Abstract

This study aimed to examine the protective effect of Artemisia iwayomogi extract (AI) against hypertriglyceridemia induced by a high-fat diet (HFD) in mice and to uncover the underlying molecular mechanisms. C57BL/6N mice were fed chow, HFD, HFD + 0.1% AI, HFD + 0.25% AI, or HFD + 0.5% AI for 10 weeks. The addition of 0.25% and 0.5% AI resulted in dose-dependent improvements in the major parameters of hypertriglyceridemia, including plasma triglyceride, free fatty acids, apolipoprotein B, and lipoprotein lipase, with parallel reductions in body weight gain, hepatic lipid accumulation, and insulin resistance. These beneficial effects were accompanied by the activation of adiponectin-adenosine monophosphate-activated protein kinase (AMPK) mediated signaling cascades in the liver, which downregulated molecules involved in lipogenesis and concurrently upregulated molecules related to fatty acid oxidation. The downregulation of molecules involved in very low density lipoprotein assembly, which was associated with improved hepatic insulin signaling, also appeared to contribute to the AI-induced attenuation of hypertriglyceridemia.

Sini decoction intervention on atherosclerosis via PPARγ-LXRα-ABCA1 pathway in rabbits

“…In addition, HDL-C levels in the serum and liver were also affected with a moderate increase following long-term HFD feeding (P<0.05). Similar findings were also obtained in hypercholesterolemia mice fed a HFD [ 34 , 35 , 36 ]. However, although HDL-C increased with slightly statistical significance, the increasing fold of LDL-C was more obvious.…”

Hepatoprotective Effects of Steamed and Freeze-Dried Mature Silkworm Larval Powder against Ethanol-Induced Fatty Liver Disease in Rats

“…To examine the underlying molecular mechanism, we examined the effect of SMSP supplementation on hepatic lipid metabolism such as lipogenesis and free fatty acid (FFA) oxidation. AMPK is one of the key activators of the lipogenesis and FFA oxidation catabolism [23]; we tested whether prolonged SMSP supplementation could modulate the AMPK pathways in the liver of alcohol-treated rats. Western blot results showed that SMSP administration significantly increased the phosphorylation of AMPK reduced by ethanol treatment.…”

Effects of Artemisia herba-alba or olive leaf (Olea europaea) powder supplementation on growth performance, carcass yield, and blood biochemical parameters in broilers

“…Mahmoodly [2] reported its significant use in African folk medicine. Indeed, Artemisia is known for its anti-inflammatory effects [3], hypocholesterolemia, and hypotriglyceridemia [4-7]. In folk medicine, in Kabyle region of Algeria, this grass is used to treat several symptoms such as digestive problems (diarrhea and stomach upset) and respiratory problems (bronchitis and cough).…”

“…In folk medicine, in Kabyle region of Algeria, this grass is used to treat several symptoms such as digestive problems (diarrhea and stomach upset) and respiratory problems (bronchitis and cough). Furthermore, antihelminthic and antileishmanial effects of Artemisia were reported in several studies [4,8-10].…”