Artemisia Species with High Biological Values as a Potential Source of Medicinal and Cosmetic Raw Materials

Ekiert, Halina; Klimek-Szczykutowicz, Marta; Rzepiela, Agnieszka; Klin, Paweł; Szopa, Agnieszka

doi:10.3390/molecules27196427

Cited by 40 publications

(33 citation statements)

References 192 publications

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“…Many species of the genus Artemisia ( Figure 1 ) have different proven medicinal properties and are used for treating diseases such as malaria, cancer, and hepatitis [ 28 , 29 , 30 ], and have even shown efficacy against COVID-19 [ 31 , 32 , 33 , 34 ]. Traditional treatments led to the testing of different Artemisia species and their extracts against several pathogens, including mycobacteria in vitro and in vivo in a murine model of tuberculosis [ 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Artemisia afra and Artemisia annua Extracts Have Bactericidal Activity against Mycobacterium tuberculosis in Physiologically Relevant Carbon Sources and Hypoxia

et al. 2023

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Mycobacterium tuberculosis (Mtb) is a deadly pathogen and causative agent of human tuberculosis, causing ~1.5 million deaths every year. The increasing drug resistance of this pathogen necessitates novel and improved treatment strategies. A crucial aspect of the host–pathogen interaction is bacterial nutrition. In this study, Artemisia annua and Artemisia afra dichloromethane extracts were tested for bactericidal activity against Mtb strain mc26230 under hypoxia and various infection-associated carbon sources (glycerol, glucose, and cholesterol). Both extracts showed significant bactericidal activity against Mtb, regardless of carbon source. Based on killing curves, A. afra showed the most consistent bactericidal activity against Mtb for all tested carbon sources, whereas A. annua showed the highest bactericidal activity in 7H9 minimal media with glycerol. Both extracts retained their bactericidal activity against Mtb under hypoxic conditions. Further investigations are required to determine the mechanism of action of these extracts and identify their active constituent compounds.

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Section: Introductionmentioning

confidence: 99%

Artemisia afra and Artemisia annua Extracts Have Bactericidal Activity against Mycobacterium tuberculosis in Physiologically Relevant Carbon Sources and Hypoxia

et al. 2023

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“…Artemisia L. is a genus of shrubs and herbs native to temperate Asia (northern temperate regions) [ 1 , 2 ] and it belongs to the Asteraceae family [ 3 ], which are mainly found in Asia, North America, and Europe [ 4 ]. Artemisia species are very important medicinal plants which are currently the subject of bioactive compounds attention because of their cosmetic products, essential oil production, chemical diversity, and biological activity [ 3 , 5 , 6 ]. For example, the extract of shoots, leaves, and flowers of Artemisia species is used traditionally for the treatment of different dieses such as infectious ulcers, inflammations, malaria, and gangrenous ulcers [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the oil obtained from Artemisia species has been used for hardly curable infectious ulcers treatment and has become famous due to its effects [ 9 ], which are insecticidal [ 10 ], anticancer [ 11 ], antimicrobial [ 12 ], and anti-malaria [ 13 , 14 ]. Further, the species of Artemisia is being used in the production of cosmetic products extensively [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemicals Identification and Bioactive Compounds Estimation of Artemisia Species Grown in Saudia Arabia

2023

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Artemisia species are very important medicinal plants, particularly in the Middle East and in developing countries. Their products have been used in traditional and medicine contemporary for the treating of infectious ulcers, gangrenous ulcers, inflammations, and malaria. Artemisinin derived from Artemisia species has been used as a drug in many countries for malaria disease treatment. Hence, this study aimed to identify and evaluate the bioactive compounds of three species of Artemisia (Artemisia judaica, Artemisia monosperma, and Artemisia sieberi) growing in Saudi Arabia. Therefore, several analytical techniques, such as gas chromatography–mass spectrometry (GC-MS), UV-Visible spectrophotometry (UV-Vis), and high-performance liquid chromatography (HPLC), with reference standards, were used. The GC-MS analysis of the artemisia species revealed many bioactive constituents associated with plant secondary metabolites; some of these identified phytochemical components have biological activity. A. Judaica showed the highest number of bioactive compounds, followed by A. sieberi and A. monosperma. Further, the total phenol, total flavonoid, total tannin, terpenoids, and TCA were estimated. Furthermore, biomolecules such gallic acid, tannin acid, quercetin, and artemisinin in different artemisia species were quantified using HPLC with the reference standard. The amount of artemisinin in the leaf extract of these species (A. sieberi, A. Judaica, and A. monosperma) was found to be about 3.01, 2.5, and 1.9 mg/g DW, respectively. Moreover, the antioxidant activity of the samples was estimated. The obtained results have shown that these species possessed high antioxidant activity, and the scavenging of the DPPH radical and hydrogen peroxide were found to be raised with the increase in the plant extract concentration. This reflects the number of bioactive compounds in these species. The findings of this research support and justify the utilization of Artemisia species in folk medicine in the Middle East.

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“…Essential oils or extracts from different parts of Artemisia ssp. have been characterized by antibacterial, antifungal, and antioxidant activities [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

A Dietary Plant Extract Formulation Helps Reduce Flea Populations in Cats: A Double-Blind Randomized Study

Banuls

Brun

Blua³

et al. 2023

Pharmaceuticals

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There is a growing demand for natural products to be used to control fleas in pets. A prospective, double-blind, randomized, placebo-controlled study evaluated the efficacy of the biological plant-based food supplement Bioticks® (thyme, rosemary, lemon balm, fenugreek, wormwood, and lemongrass extracts) as a flea control product in naturally flea-infested cats with an indoor–outdoor lifestyle. Ten cats were used as placebo controls (group A). Ten other cats were fed the same daily diet but supplemented with Bioticks® (group B). Fleas were counted by combing at D0 and D0 + 14 days, then one, two, three, four, and five months after the start of this study. No flea treatment was administered, and no environmental changes were made for six months prior to the start and throughout this study. The product was well-tolerated. The mean flea population in group B progressively and steadily decreased to reach 3.3 ± 2.1 at month five. At the same time and under similar maintenance conditions, the average flea population in group A remained stable (14.3 ± 2.5) until the fifth month. The percentages of efficacy (Abbott formula) in group B compared to group A was 27%, 20%, 52%, 66%, and 77%, respectively, at one, two, three, four, and five months after the start of this study.

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Artemisia Species with High Biological Values as a Potential Source of Medicinal and Cosmetic Raw Materials

Cited by 40 publications

References 192 publications

Artemisia afra and Artemisia annua Extracts Have Bactericidal Activity against Mycobacterium tuberculosis in Physiologically Relevant Carbon Sources and Hypoxia

Artemisia afra and Artemisia annua Extracts Have Bactericidal Activity against Mycobacterium tuberculosis in Physiologically Relevant Carbon Sources and Hypoxia

Phytochemicals Identification and Bioactive Compounds Estimation of Artemisia Species Grown in Saudia Arabia

A Dietary Plant Extract Formulation Helps Reduce Flea Populations in Cats: A Double-Blind Randomized Study

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