Artemisinin as a Chinese medicine, selectively induces apoptosis in pancreatic tumor cell line

Noori, Shokoofe; Hassan, Zuhair Muhammad; Farsam, Vida

doi:10.1007/s11655-013-1454-2

Cited by 23 publications

(11 citation statements)

References 20 publications

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“…Previous studies have shown that artemisinin induced apoptosis in pancreatic tumor cells (36), lung adenocarcinoma cells (37), liver cancer cells (38), and non-small cell lung cancer cells (39). In the present study, we first demonstrated that artemisinin induced the cell death and apoptosis of neuroblastoma cells at a lower dose than that for clinical usage.…”

Section: Discussionsupporting

confidence: 59%

Artemisinin reduces cell proliferation and induces apoptosis in neuroblastoma

Zhu

Liu

et al. 2014

Oncology Reports

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Artemisinin, a natural product from the Chinese medicinal plant, Artemisia annua L., is commonly used in the treatment of malaria, and has recently been reported to have potent anticancer activity in various types of human tumors. Yet, the effect of artemisinin on neuroblastoma is still unclear. In the present study, we aimed to investigate the effects of artemisinin on neuroblastoma cells. We observed that artemisinin significantly inhibited cell growth and proliferation, and caused cell cycle arrest in the G1 phase in neuroblastoma cell lines. Annexin V-FITC/PI staining assay revealed that artemisinin markedly induced apoptosis. Soft agar assays revealed that artemisinin suppressed the ability of clonogenic formation of neuroblastoma cells and a xenograft study in NOD/SCID mice showed that artemisinin inhibited tumor growth and development in vivo. Therefore, our results suggest that the Chinese medicine artemisinin could serve as a novel potential therapeutic agent in the treatment of neuroblastoma.

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Section: Discussionsupporting

confidence: 59%

Artemisinin reduces cell proliferation and induces apoptosis in neuroblastoma

Zhu

Liu

et al. 2014

Oncology Reports

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“…DHA and artesunate are the most studied ART derivatives for cancer treatment, and artesunate will be discussed in a separate section. The anti-cancer effects of ARTs are demonstrated in a broad spectrum of cancer cells including lung, liver, pancreatic, colorectal, esophageal, breast, ovarian, cervical, head and neck, and prostate cancers [183][184][185][186][187][188][189][190][191]. The anti-cancer activities of ARTs include induction of apoptosis and cell cycle arrest, inhibition of cell proliferation and growth, metastasis and angiogenesis [189,[192][193][194][195].…”

Section: Artemisininsmentioning

confidence: 99%

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer activities, including antiproliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects, as well as regulate autophagy, reverse multidrug resistance, balance immunity, and enhance chemotherapy in vitro and in vivo. To provide new insights into the critical path ahead, we systemically reviewed the most recent advances (reported since 2011) on the key compounds with anti-cancer effects derived from Chinese herbal medicine (curcumin, epigallocatechin gallate, berberine, artemisinin, ginsenoside Rg3, ursolic acid, silibinin, emodin, triptolide, cucurbitacin B, tanshinone I, oridonin, shikonin, gambogic acid, artesunate, wogonin, β-elemene, and cepharanthine) in scientific databases (PubMed, Web of Science, Medline, Scopus, and Clinical Trials). With a broader perspective, we focused on their recently discovered and/or investigated pharmacological effects, novel mechanism of action, relevant clinical studies, and their innovative applications in combined therapy and immunomodulation. In addition, the present review has extended to describe other promising compounds including dihydroartemisinin, ginsenoside Rh2, compound K, cucurbitacins D, E, I, tanshinone IIA and cryptotanshinone in view of their potentials in cancer therapy. Up to now, the evidence about the immunomodulatory effects and clinical trials of natural anti-cancer compounds from Chinese herbal medicine is very limited, and further research is needed to monitor their immunoregulatory effects and explore their mechanisms of action as modulators of immune checkpoints.

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“…induced ROS-dependent apoptosis in human colon (DLD-1) and endometrium (ECC-1) cancer cells ( 31 ). The isolated sesquiterpenoid lactones from the genus Artemisia, like artemisinin and dihydroartemisinin, have been able to induce apoptosis in different cancerous cell lines ( 32 33 ). In contrast to the terpenoid extract of A. ciniformis , no sesquiterpene lactone has been detected in that of A. biennis ( 34 ).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the cytotoxic effects of different fractions of Artemisia ciniformis and Artemisia biennis on B16/F10, PC3 and MCF7 Cells

Ramazani¹,

Tayarani‐Najaran²,

Shokoohinia³

et al. 2020

Res Pharma Sci

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Background and purpose: Artemisia is one of the well-known herbal medicinal plants for antimicrobial, insecticidal, antioxidant, and antimalarial activities. The antiproliferative effects of dichloromethane extracts of Artemisia biennis ( A. biennis ) and A. ciniformis and the petroleum ether extract of A. ciniformis have been demonstrated previously on human cancerous cell lines. In the current study, further fractionation was carried out on the aforementioned extracts and their cytotoxic effects were evaluated on three human cancer cell lines; B16/F10, PC3, and MCF7. F1 to F16, F1’ to F11’, and F1” to F10” were resulted from the fractionation of dichloromethane extracts of A. biennis, A. ciniformis , and petroleum ether extract of A. ciniformis , respectively. Experimental approach: The cytotoxic effects of 16 (F1-F16), 11 (F1’-F11’) and 10 (F1”-F10”) fractions, on B16/F10, PC3, and MCF7 cell lines were assessed using resazurin to measure viability and propidium iodide staining (sub G1) and flow cytometry to detect apoptosis. Findings / Results: The results showed that, some fractions at 100 μg/mL decreased cell viability. F2” in B16/F10 cells, F2, F4-F6, F10’, F11’, and F2” in PC3 cells, and F10’, F11’, and F2” in MCF7 significantly decreased cell viability in a concentration-dependent manner (12.5-50 μg/mL). Among different fractions, F2” demonstrated the most potent cytotoxic effects on cancer cell lines ( P < 0.001). All of the mentioned fractions (except F11’ on PC3 cells) increased the number of apoptotic cells and showed the cytotoxic effects on cancer cells compared with the control group. Conclusion and implications: A. biennis and A. ciniformis are suggested as the potential sources of cytotoxic phytochemicals. The probable presence of terpenoids, steroids, and alkaloids in the selected fractions is proposed based on the preliminary phytochemical study.

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Artemisinin as a Chinese medicine, selectively induces apoptosis in pancreatic tumor cell line

Abstract: Artemisinin can induce apoptosis in the RIN cells via the generation of ROS and triggering the intrinsic pathway of cell death.

Cited by 23 publications

References 20 publications

Artemisinin reduces cell proliferation and induces apoptosis in neuroblastoma

Artemisinin reduces cell proliferation and induces apoptosis in neuroblastoma

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Comparison of the cytotoxic effects of different fractions of Artemisia ciniformis and Artemisia biennis on B16/F10, PC3 and MCF7 Cells

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