Artemisinin enhances the anti-tumor immune response in 4T1 breast cancer cells in vitro and in vivo

Cao, Yu; Feng, Yanghe; Gao, Liwei; Li, Xiaoying; Jin, Quanxiu; Wang, Yuying; Xu, Yingying; Jin, Feng; Lu, Shi‐Long; Wei, Minjie

doi:10.1016/j.intimp.2019.01.041

Cited by 88 publications

(50 citation statements)

References 43 publications

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“…DHA and artesunate are the most studied ART derivatives for cancer treatment, and artesunate will be discussed in a separate section. The anti-cancer effects of ARTs are demonstrated in a broad spectrum of cancer cells including lung, liver, pancreatic, colorectal, esophageal, breast, ovarian, cervical, head and neck, and prostate cancers [183][184][185][186][187][188][189][190][191]. The anti-cancer activities of ARTs include induction of apoptosis and cell cycle arrest, inhibition of cell proliferation and growth, metastasis and angiogenesis [189,[192][193][194][195].…”

Section: Artemisininsmentioning

confidence: 99%

“…DHA can enhance the anti-tumor cytolytic activity of γδ T cells against human pancreatic cancer SW1990, BxPC-3 and Panc-1 cells [208], and ART also potentiates the cytotoxicity of NK cells to mediate anti-tumor activity [209]. Similarly, ART inhibits tumor growth through T cell activation and T reg suppression in breast cancer 4T1 xenograft mice [188]. Therefore, this provides a novel strategy for treating pancreatic cancer with immunotherapy.…”

Section: Artemisininsmentioning

confidence: 99%

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Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer activities, including antiproliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects, as well as regulate autophagy, reverse multidrug resistance, balance immunity, and enhance chemotherapy in vitro and in vivo. To provide new insights into the critical path ahead, we systemically reviewed the most recent advances (reported since 2011) on the key compounds with anti-cancer effects derived from Chinese herbal medicine (curcumin, epigallocatechin gallate, berberine, artemisinin, ginsenoside Rg3, ursolic acid, silibinin, emodin, triptolide, cucurbitacin B, tanshinone I, oridonin, shikonin, gambogic acid, artesunate, wogonin, β-elemene, and cepharanthine) in scientific databases (PubMed, Web of Science, Medline, Scopus, and Clinical Trials). With a broader perspective, we focused on their recently discovered and/or investigated pharmacological effects, novel mechanism of action, relevant clinical studies, and their innovative applications in combined therapy and immunomodulation. In addition, the present review has extended to describe other promising compounds including dihydroartemisinin, ginsenoside Rh2, compound K, cucurbitacins D, E, I, tanshinone IIA and cryptotanshinone in view of their potentials in cancer therapy. Up to now, the evidence about the immunomodulatory effects and clinical trials of natural anti-cancer compounds from Chinese herbal medicine is very limited, and further research is needed to monitor their immunoregulatory effects and explore their mechanisms of action as modulators of immune checkpoints.

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Section: Artemisininsmentioning

confidence: 99%

Section: Artemisininsmentioning

confidence: 99%

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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“…ARS compounds could exert tumouricidal activity in multiple types of tumours, such as hepatocellular carcinoma, breast cancer, prostate cancer and ovarian cancer, and potentially regulate cell growth, apoptosis, the cell cycle and invasion . Interestingly, ARS compounds could induce cell autophagy in ovarian cancer and enhance the antitumour immune response of T cells . Based on the regulation of autophagy by ARS compounds and the close link between autophagy and metabolism, we propose that ARS compounds regulate the progression of cancer at least partially by reprogramming cancer cell metabolism.…”

Section: Introductionmentioning

confidence: 95%

“…artesunate, distant seeding, glioma, mevalonate pathway, senescence tumouricidal activity in multiple types of tumours, such as hepatocellular carcinoma, breast cancer, prostate cancer and ovarian cancer, 4,7,8,[11][12][13][14][15] and potentially regulate cell growth, apoptosis, the cell cycle and invasion. 5,7,8,12 Interestingly, ARS compounds could induce cell autophagy in ovarian cancer 12 and enhance the antitumour immune response of T cells.…”

mentioning

confidence: 99%

“…5,7,8,12 Interestingly, ARS compounds could induce cell autophagy in ovarian cancer 12 and enhance the antitumour immune response of T cells. 4 Based on the regulation of autophagy by ARS compounds and the close link between autophagy and metabolism, we propose that ARS compounds regulate the progression of cancer at least partially by reprogramming cancer cell metabolism.…”

mentioning

confidence: 99%

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Artesunate inhibits the mevalonate pathway and promotes glioma cell senescence

Wei

Liu

Chen

et al. 2019

J Cellular Molecular Medi

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Glioma is a common brain malignancy for which new drug development is urgently needed because of radiotherapy and drug resistance. Recent studies have demonstrated that artemisinin (ARS) compounds can display antiglioma activity, but the mechanisms are poorly understood. Using cell lines and mouse models, we investigated the effects of the most soluble ARS analogue artesunate (ART) on glioma cell growth, migration, distant seeding and senescence and elucidated the underlying mechanisms. Artemisinin effectively inhibited glioma cell growth, migration and distant seeding. Further investigation of the mechanisms showed that ART can influence glioma cell metabolism by affecting the nuclear localization of SREBP2 (sterol regulatory element‐binding protein 2) and the expression of its target gene HMGCR (3‐hydroxy‐3‐methylglutaryl coenzyme A reductase), the rate‐limiting enzyme of the mevalonate (MVA) pathway. Moreover, ART affected the interaction between SREBP2 and P53 and restored the expression of P21 in cells expressing wild‐type P53, thus playing a key role in cell senescence induction. In conclusion, our study demonstrated the new therapeutic potential of ART in glioma cells and showed the novel anticancer mechanisms of ARS compounds of regulating MVA metabolism and cell senescence.

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Pyronaridine: An update of its pharmacological activities and mechanisms of action

Bailly

2020

Biopolymers

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Pyronaridine (PYR) is an erythrocytic schizonticide with a potent antimalarial activity against multidrug-resistant Plasmodium. The drug is used in combination with artesunate for the treatment of uncomplicated P. falciparum malaria, in adults and children. The present review briefly retraces the discovery of PYR and recent antimalarial studies which has led to the approval of PYR/artesunate combination (Pyramax) by the European Medicines Agency to treat uncomplicated malaria worldwide. PYR Pyronaridine (PYR, Figure 1), initially known as "antimalaria drug 7351", is a benzo-naphthyridine derivative originally synthesized in 1979 [1] and developed in China from the early 1980s. [2][3][4] Rapidly, experimental studies demonstrated that this compound was more active than chloroquine against different isolates of Plasmodium falciparum, the malaria pathogen.

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Artemisinin enhances the anti-tumor immune response in 4T1 breast cancer cells in vitro and in vivo

Cited by 88 publications

References 43 publications

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Artesunate inhibits the mevalonate pathway and promotes glioma cell senescence

Pyronaridine: An update of its pharmacological activities and mechanisms of action

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