Artemisinin loaded chitosan magnetic nanoparticles for the efficient targeting to the breast cancer

Natesan, Subramanian; Ponnusamy, Chandrasekar; Sugumaran, Abimanyu; Chelladurai, Senthilkumar; Palaniappan, Sharavanan Shanmugam; Palanichamy, Rajaguru

doi:10.1016/j.ijbiomac.2017.03.137

Cited by 79 publications

(25 citation statements)

References 25 publications

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“…Moreover, chitosan has the propensity to encapsulate or coat a drug over the surface and can also control the drug release prociency. 24 The polymer has been investigated as an adjuvant and for a wide variety of activities, including anti-microbial activity, anti-tumor activity, blood hemostatic activity, and anti-diabetic activity, as well as for enzyme immobilization and wound dressing applications. [25][26][27][28] The mucoadhesive nature of chitosan raises the residual time at the site of absorption and its cationic property permits ionic linkages, which happens with multivalent anions.…”

Section: Introductionmentioning

confidence: 99%

α-Santalol functionalized chitosan nanoparticles as efficient inhibitors of polo-like kinase in triple negative breast cancer

et al. 2020

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Section: Introductionmentioning

confidence: 99%

α-Santalol functionalized chitosan nanoparticles as efficient inhibitors of polo-like kinase in triple negative breast cancer

et al. 2020

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“…These features allow them to be used in many applications. For example, in medicine, anticancer drugs are loaded with magnetic materials to be directed to particular sites thus reducing the dose required in several therapies and minimizing side-effects [1,2]; in effluent treatments, for the removal of dyes, heavy metals, and biologically active compounds with high separation efficiency and reusability [3][4][5][6], etc.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of magnetic-montmorillonite and magnetic-organo-montmorillonite: Surface sites involved on cobalt sorption

Barraqué¹,

Montes

Fernández³

et al. 2018

Journal of Magnetism and Magnetic Materials

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Montmorillonite magnetic-clay nanoparticles (MtMag) and its exchanged product with hexadecyltrimethylammonium (O100MtMag) were synthetized by alkaline oxidation of ferrous sulfate, characterized by diverse techniques (XRD, Mössbauer spectroscopy, VSM, SEM, Zeta Potential, total specific surface area, TOC) and used as Co 2+ sorbents. The magnetic characteristic of these materials allows them to be used in cases of decontamination of water polluted with dangerous materials, such as radioactive ones, reducing the risk to health due to indirect manipulation by means of external magnetic fields. For comparison, samples without magnetic material (O100Mt) and in absence of clay (Mag) were also synthetized. The synthesis of magnetic materials disclosed the presence of magnetite and goethite nanoparticles, while the saturation magnetization displayed by O100MtMag was higher than that obtained for MtMag, indicating the existence of a higher amount of magnetite particles in the first one. This suggests that O100MtMag could be manipulated easier than MtMag through external magnetic fields. Moreover, the surface electric charge of MtMag sample can be described as a mixture of Magnetite and montmorillonite, with ratios related to the surface of both components. Co 2+ sorption percentages, using an initial Co 2+ concentration of 85 mg/L, resulted similar for the different materials while the Co 2+ sorption was ascribed to interactions with the montmorillonite interlayer and external surface. The current results indicate that O100MtMag is a more appropriate material than MtMag for Co 2+ removal by external magnets.

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“…In vivo and in vitro experiments also confirmed the good performance of the agent. Other researches also demonstrated that artemisinin-based nanoparticle delivery systems could particularly enhance the antitumor efficiency of artemisinin-related compounds [ 161 , 162 ]. Therefore, the development of artemisinin-based nanoplatform is an effective way to find potent artemisinin derivatives with good bioavailability and targeting property.…”

Section: New Directionsmentioning

confidence: 99%

Antitumor Research on Artemisinin and Its Bioactive Derivatives

Zhang

et al. 2018

Nat. Prod. Bioprospect.

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Cancer is the leading cause of human death which seriously threatens human life. The antimalarial drug artemisinin and its derivatives have been discovered with considerable anticancer properties. Simultaneously, a variety of target-selective artemisinin-related compounds with high efficiency have been discovered. Many researches indicated that artemisinin-related compounds have cytotoxic effects against a variety of cancer cells through pleiotropic effects, including inhibiting the proliferation of tumor cells, promoting apoptosis, inducing cell cycle arrest, disrupting cancer invasion and metastasis, preventing angiogenesis, mediating the tumor-related signaling pathways, and regulating tumor microenvironment. More importantly, artemisinins demonstrated minor side effects to normal cells and manifested the ability to overcome multidrug-resistance which is widely observed in cancer patients. Therefore, we concentrated on the new advances and development of artemisinin and its derivatives as potential antitumor agents in recent 5 years. It is our hope that this review could be helpful for further exploration of novel artemisinin-related antitumor agents.Graphical Abstract

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Artemisinin loaded chitosan magnetic nanoparticles for the efficient targeting to the breast cancer

Cited by 79 publications

References 25 publications

α-Santalol functionalized chitosan nanoparticles as efficient inhibitors of polo-like kinase in triple negative breast cancer

α-Santalol functionalized chitosan nanoparticles as efficient inhibitors of polo-like kinase in triple negative breast cancer

Synthesis and characterization of magnetic-montmorillonite and magnetic-organo-montmorillonite: Surface sites involved on cobalt sorption

Antitumor Research on Artemisinin and Its Bioactive Derivatives

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