Artemisinins and their impact on inhibitory neurotransmission

Pacios-Michelena, Anabel; Kasaragod, Vikram Babu; Schindelin, Hermann

doi:10.1016/j.coph.2021.04.008

Cited by 6 publications

(3 citation statements)

References 49 publications

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“…Artemisinin and its derivatives are found in Artemisia annua . They produce oxygen radicals and can influence inhibitory neurotransmission ( Pacios-Michelena et al, 2021 ). These cause oxidative stress through the effects on mitochondrial action and electron transfer in the parasite ( Cumming et al, 1998 ; Beshay, 2018 ) and kill helminths ( Fathy, 2011 ; Cala et al, 2014 ) ( Figure 7B ).…”

Section: Resultsmentioning

confidence: 99%

Emerging Anthelmintic Resistance in Poultry: Can Ethnopharmacological Approaches Offer a Solution?

et al. 2022

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Limited pharmacological studies have been conducted on plant species used against poultry helminths. The objective of this study was to provide a basis for plant based anthelmintics as possible alternatives against poultry anthelmintic resistance. The study justified the need for alternative anthelmintics. The study places emphasis on the increasing anthelmintic resistance, mechanism of resistance, and preparational protocols for plant anthelmintics and their associated mechanism of action. Pharmaceutical studies on plants as alternative therapies for the control of helminth parasites have not been fully explored especially in several developing countries. Plants from a broad range of species produce a wide variety of compounds that are potential anthelmintics candidates. Important phenolic acids have been found in Brassica rapa L. and Terminalia avicenniodes Guill. and Perri that affect the cell signaling pathways and gene expression. Benzo (c) phenanthridine and isoquinoline alkaloids are neurotoxic to helminths. Steroidal saponins (polyphyllin D and dioscin) interact with helminthic mitochondrial activity, alter cell membrane permeability, vacuolation and membrane damage. Benzyl isothiocyanate glucosinolates interfere with DNA replication and protein expression, while isoflavones from Acacia oxyphylla cause helminth flaccid paralysis, inhibit energy generation, and affect calcium utilization. Condensed tannins have been shown to cause the death of nematodes and paralysis leading to expulsion from the gastro-intestinal tract. Flavonoids from Chenopodium album L and Mangifera indica L act through the action of phosphodiesterase and Ca2+-ATPase, and flavonoids and tannins have been shown to act synergistically and are complementary to praziquantel. Artemisinins from Artemisia cina O. Berg are known to disrupt mitochondrial ATP production. Terpenoids from Cucurbita moschata L disrupt neurotransmission leading to paralysis as well as disruption of egg hatching. Yeast particle encapsulated terpenes are effective for the control of albendazole-resistant helminths.

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Section: Resultsmentioning

confidence: 99%

Emerging Anthelmintic Resistance in Poultry: Can Ethnopharmacological Approaches Offer a Solution?

et al. 2022

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“…Artemisinin (Art), as a sesquiterpene lactone with peroxyl group extracted from Artemisia annua L., has been widely used in the treatment of malaria due to the characteristics of high efficiency and low toxicity, and has saved millions of lives in the past 40 years (Correa et al, 2019). In recent years, it has been reported to treat inflammation, immune regulation, anti-fibrosis, and other pathological processes (Pacios-Michelena et al, 2021;Surowiak et al, 2021;Zhang et al, 2021b). Dihydroartemisinin (DHA) is a derivative of artemisinin and harbors nearly 10 times bioavailability as much as that of artemisinin.…”

Section: Introductionmentioning

confidence: 99%

Dihydroartemisinin ameliorates palmitate-induced apoptosis in cardiomyocytes via regulation on miR-133b/Sirt1 axis

Qi¹,

Xu²,

Li³

et al. 2022

Biocell

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Excessive fat ectopically deposited in the non-adipose tissues is considered as one of the leading causes of myopathy. The aim of this study was to investigate the role of Dihydroartemisinin (DHA) in palmitate (PAL)incubated H9c2 cells (lipotoxicity-induced cell injury model). Cell viability of PAL-treated cells was determined by MTT assay, and apoptotic regulators were examined by qRT-PCR and western blot analysis, in the absence or in the presence of DHA, respectively. Expression levels of miR-133b and Sirt1 were also evaluated by qRT-PCR and western blotting examination. PAL decreased the viability of H9c2 cells and enhanced the expression of apoptotic genes. DHA reversed the effect of PAL on cell viability and lowed the level of Caspase3 and Bax. It also lowered the expression of miR-133b, while enhanced the expression of Bcl-2. Sirt1 was revealed as target of miR-133b through transcriptional regulation and the process was affected by DHA. DHA partially protected against the PAL-induced lipotoxicity by influencing the expression of miR-133b that hindered the activity of Sirt1. DHA may be used as a potential treatment in clinical management for lipotoxicity induced heart complications.

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“…Traditional Chinese medicine (TCM) culture has a history of thousands of years and is a crucial cultural heritage of humankind [ 1 , 2 ]. For example, artemisinin is a Chinese medicine developed on the basis of modern approaches and theories that can efficiently reduce the mortality of malaria, representing a crucial example of the modernization process of TCM [ 3 , 4 ]. The modernization of TCM is an inevitable trend with the development of pharmaceutical science, and understanding the pharmaceutical mechanisms behind TCM is the key to promoting its modernization process [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Correlation between the redox activity of Polygonum multiflorum extract and its extraction technology with Chinese liquor (Baijiu): An electrochemistry-based study

Wang

et al. 2022

Heliyon

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Artemisinins and their impact on inhibitory neurotransmission

Cited by 6 publications

References 49 publications

Emerging Anthelmintic Resistance in Poultry: Can Ethnopharmacological Approaches Offer a Solution?

Emerging Anthelmintic Resistance in Poultry: Can Ethnopharmacological Approaches Offer a Solution?

Dihydroartemisinin ameliorates palmitate-induced apoptosis in cardiomyocytes via regulation on miR-133b/Sirt1 axis

Correlation between the redox activity of Polygonum multiflorum extract and its extraction technology with Chinese liquor (Baijiu): An electrochemistry-based study

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