Arterial and venous thromboembolic disease in a patient with COVID-19: A case report

Brüggemann, Renée; Gietema, Hester A.; Jallah, Borefore; Cate, Hugo Ten; Stehouwer, Coen D. A.; Spaetgens, Bart

doi:10.1016/j.thromres.2020.04.046

Cited by 40 publications

(43 citation statements)

References 9 publications

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“…Despite therapy, multiple pulmonary embolisms developed on the seventh day, which was confirmed via the third CTPA during his admission [23]. The patient was further managed therapeutically with tinzaparin (LMWH) for PE [23].…”

Section: Cerebrovascular Eventmentioning

confidence: 94%

Section: Cerebrovascular Eventmentioning

confidence: 99%

“…A case report conducted by Brüggemann et al [ 23 ] reported arterial and venous thromboembolic events in a 59-year-old male patient who tested positive for COVID-19. He had a past medical history of peripheral arterial disease and presented to the ED with pulmonary symptoms (dyspnea, chest pain, cough), fever, tachycardia, and headache [ 23 ]. A CT-pulmonary angiography (CTPA) was ordered due to high suspicions of a pulmonary embolism (PE) due to signs of tachycardia, chest pain, and elevated d -dimer; however, this was ruled out and imaging further demonstrated COVID-19 pneumonia impressions [ 23 ].…”

Section: Central Nervous System–related Symptomsmentioning

confidence: 99%

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The Neurological Complexities and Prognosis of COVID-19

Padda

Khehra

Jaferi

et al. 2020

SN Compr. Clin. Med.

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Several neurological manifestations and complications linked to SARS-CoV-2 have been reported along with well-known respiratory pathology. The global active transmission of SARS-CoV-2 and its unexplained characteristics has led to a pandemic. Since its rapid emergence from Wuhan, China, in December 2019, several studies have reported the impacts of COVID-19 on the CNS and PNS and its implications. This comprehensive review article comprises case reports, case series, metaanalysis, cohort studies, retrospective studies, and narrative reviews focusing on COVID-19-associated CNS and PNS complexities. The authors searched for over 200 articles and used 52 publications related to the neurological complexities of COVID-19 affecting the CNS and PNS as part of the literature review process. The predominant CNS symptoms noted in COVID-19 patients were headaches and dizziness, and the most common PNS symptoms were alterations in smell and taste. Case reports on headache/dizziness, intracerebral hemorrhage, acute hemorrhagic necrotizing encephalopathy, meningitis/encephalitis, encephalopathy, cerebrovascular events, chemosensory dysfunction, Guillain-Barre syndrome, and acute transverse myelitis/acute necrotizing myelitis in PCR-confirmed SARS-CoV-2 subjects are also reported. New-onset neurological symptoms were also observed in children with PCR-confirmed SARS-CoV-2 that developed pediatric multisystem inflammatory syndrome (PIMS). This comprehensive review article will assist the clinicians and researchers to gain information about the neurological manifestations and complications associated with COVID-19 and develop planning to treat these symptoms in concerned patients of all ages. However, it is unclear whether SARS-CoV2-associated neurological effects are due to primary infections or secondary response to the possible mechanisms discussed in this review.

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Section: Cerebrovascular Eventmentioning

confidence: 94%

Section: Cerebrovascular Eventmentioning

confidence: 99%

Section: Central Nervous System–related Symptomsmentioning

confidence: 99%

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The Neurological Complexities and Prognosis of COVID-19

Padda

Khehra

Jaferi

et al. 2020

SN Compr. Clin. Med.

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“…First series of autopsies in COVID-19 patients showed thrombosis in small pulmonary vessels [10], and first clinical cases with PE in COVID-19 patients has already been published [11]. Interestingly, Klok et al [12] found, in a retrospective study in 184 intensive care unit (ICU) patients with severe COVID-19 pneumonia, a high prevalence of thrombotic complications and, by far, pulmonary embolism (PE) was the most frequent.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of pulmonary embolism in patients with COVID-19 pneumonia and high D-dimer values: A prospective study

et al. 2020

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bolic disease from the non-PE group. D-dimer, platelet count, and, C reactive protein values were significantly higher among PE patients. D-dimer values correlated with the radiologic magnitude of PE (p<0.001). Conclusions Patients with COVID-19 pneumonia and D-dimer values higher than 1 μg/mL presented a high prevalence of PE, regardless of clinical suspicion. We consider that these findings could contribute to improve the prognosis of patients with COVID-19 pneumonia, by initiating anticoagulant therapy when a PE is found.

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“…In this case the patient developed both arterial and vein thrombosis related to vascular devices despite he was receiving therapeutic anticoagulant. Currently, a French study has found a high rate of thromboembolic events in COVID-19 patients treated with therapeutic anticoagulation (7,8).…”

Section: Discussionmentioning

confidence: 99%

Arterial and vein related catheters thrombosis in a patient with COVID-19 : a case report.

Haoudar

Kantri

Ziati

et al. 2020

Preprint

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Patients with acute respiratory distress syndrome due to infection with the novel coronavirus SARS-COV2 are currently considered at high risk of developing thromboembolic complications in both venous and arterial vessels. The use of anticoagulants for preventive or curative purposes should be considered to reduce the risk of thromboembolic events. We report a case of a patient with severe COVID-19 acute respiratory distress syndrome who consecutively developed a right femoral deep vein thrombosis related to the femoral central line and acute ischemia of the left upper limb related to a radial arterial line. He was under a therapeutic dose of low molecular weight heparin twice a day three days before. The femoral vein was free of thrombosis while the central line was placed under a duplex ultrasound.Thromboembolic events can occur in patients with severe COVID-19 despite therapeutic anticoagulants. Close monitoring of vascular access with duplex ultrasound may be required.

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Arterial and venous thromboembolic disease in a patient with COVID-19: A case report

Cited by 40 publications

References 9 publications

The Neurological Complexities and Prognosis of COVID-19

The Neurological Complexities and Prognosis of COVID-19

Prevalence of pulmonary embolism in patients with COVID-19 pneumonia and high D-dimer values: A prospective study

Arterial and vein related catheters thrombosis in a patient with COVID-19 : a case report.

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