Arterial and venous thromboembolism in critically ill, COVID 19 positive patients admitted to Intensive Care Unit

Elboushi, Amro; Syed, Arooj; Pasenidou, Ketino; Elmi, Liban; Keen, Irfan; Heining, Chris; Vasudev, Ashish; Tulmuntiha, Sidra; Karia, Kishan; Ramesh, Priyavarshini; Pearce, Samuel; Gao-Smith, Fang; Veenith, Tonny; Nasr, Hosaam; Sam, R.C.; Juszczak, Maciej

doi:10.1016/j.avsg.2022.02.005

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…Moreover, thrombosis can also occur in the arterial system, resulting in acute arterial occlusion, stroke, or even myocardial infarction. This was also evident in post-mortem analysis, which showed a high prevalence of thrombosis in COVID-19 patients' microvascular and macrovascular systems [4,5]. This case report presents a rare case of a thrombotic event induced by COVID-19 that affected both the arterial and venous systems in the same limb.…”

Section: Introductionmentioning

confidence: 58%

A Rare Combination of Arterial and Venous Thrombosis as a Sequalae of COVID-19

Suleimanov

Aljunibi²,

Almarhoon³

et al. 2022

Cureus

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Coronavirus disease 2019 (COVID-19) has been a devastating condition claiming millions of lives, crippling countless people, and causing economic turmoil all over the world since the outbreak started in Wuhan Province of China in December 2019. Numerous papers have been published in the literature about COVID-19-related complications affecting almost all systems in the human body. One of the severe complications of this disease is thromboembolism, which affects both the arterial and venous systems and is well documented. There are few reports about both arterial and venous system involvement in the same patient. Herein, we report the case of COVID-19, who presented with critical limb ischemia caused by both arterial and venous thrombosis.

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Section: Introductionmentioning

confidence: 58%

A Rare Combination of Arterial and Venous Thrombosis as a Sequalae of COVID-19

Suleimanov

Aljunibi²,

Almarhoon³

et al. 2022

Cureus

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Prevalence of venous thromboembolism in patients undergoing diagnostic venous ultrasound during the first SARS-CoV-2 pandemic

Torre

Nagra

Wijesinghe

et al. 2023

Vasa

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Summary: Background: Venous thromboembolism appears to be associated with severe COVID-19 infection than in those without it. However, this varies considerably depending on the cohort studied. The aims of this single-centre, multi-site retrospective cross-sectional study were to assess the number of all venous scans performed in the first month of pandemic in a large university teaching hospital, to evaluate the incidence of deep venous thrombosis (DVT), and assess the predictive ability of the clinical information available on the electronic patient record in planning work-up for DVT and prioritising ultrasound scans. Patients and methods: All consecutive patients undergoing venous ultrasound for suspected acute DVT between 1st of March and 30th of April 2020 were considered. Primary outcome was the proportion of scans positive for DVT; the secondary outcomes included association of a positive SARS-CoV-2 PCR test, demographic, clinical factors, and Wells scores. Results: 819 ultrasound scans were performed on 762 patients across the Trust in March and April 2020. This number was comparable to the corresponding pre-pandemic cohort from 2019. The overall prevalence of DVT in the studied cohort was 16.1% and was higher than before the pandemic (11.5%, p=.047). Clinical symptoms consistent with COVID-19, irrespective of the SARS-CoV-2 PCR test result (positive_COVID_PCR OR 4.97, 95%CI 2.31–10.62, p<.001; negative_COVID_PCR OR 1.97, 95%CI 1.12–3.39, p=.016), a history of AF (OR 0.20, 95%CI 0.03–0.73, p=.037), and personal history of venous thromboembolism (VTE) (OR 1.95, 95%CI 1.13–3.31, p=.014), were independently associated with the diagnosis of DVT on ultrasound scan. Wells score was not associated with the incidence of DVT. Conclusions: Amongst those referred for the DVT scan, SARS-CoV-2 PCR test was associated with an increased risk of VTE and should be taken into consideration when planning DVT work-up and prioritising diagnostic imaging. We postulate that the threshold for imaging should possibly be lower.

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A systematic review of thromboembolic complications and outcomes in hospitalised COVID-19 patients

Othman,

Zaki,

Isa

et al. 2024

BMC Infect Dis

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Thromboembolic (TE) complications [myocardial infarction (MI), stroke, deep vein thrombosis (DVT), and pulmonary embolism (PE)] are common causes of mortality in hospitalised COVID-19 patients. Therefore, this review was undertaken to explore the incidence of TE complications and mortality associated with TE complications in hospitalised COVID-19 patients from different studies. A literature search was performed using ScienceDirect and PubMed databases using the MeSH term search strategy of “COVID-19”, “thromboembolic complication”, “venous thromboembolism”, “arterial thromboembolism”, “deep vein thrombosis”, “pulmonary embolism”, “myocardial infarction”, “stroke”, and “mortality”. There were 33 studies included in this review. Studies have revealed that COVID-19 patients tend to develop venous thromboembolism (PE:1.0-40.0% and DVT:0.4-84%) compared to arterial thromboembolism (stroke:0.5-15.2% and MI:0.8-8.7%). Lastly, the all-cause mortality of COVID-19 patients ranged from 4.8 to 63%, whereas the incidence of mortality associated with TE complications was between 5% and 48%. A wide range of incidences of TE complications and mortality associated with TE complications can be seen among hospitalized COVID-19 patients. Therefore, every patient should be assessed for the risk of thromboembolic complications and provided with an appropriate thromboprophylaxis management plan tailored to their individual needs.

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Arterial and venous thromboembolism in critically ill, COVID 19 positive patients admitted to Intensive Care Unit

Cited by 3 publications

References 29 publications

A Rare Combination of Arterial and Venous Thrombosis as a Sequalae of COVID-19

A Rare Combination of Arterial and Venous Thrombosis as a Sequalae of COVID-19

Prevalence of venous thromboembolism in patients undergoing diagnostic venous ultrasound during the first SARS-CoV-2 pandemic

A systematic review of thromboembolic complications and outcomes in hospitalised COVID-19 patients

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