Arterial baroreceptor responses to intraaortic balloon assistance

Normann, Nils A.; Kennedy, John H.

doi:10.1016/0022-4804(71)90146-6

Cited by 21 publications

(14 citation statements)

References 12 publications

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“…This premise was confirmed by a previous work (4) where it was demonstrated that the two peaks seen on the aortic waveform, which are caused by left ventricular ejection in systole and balloon inflation in diastole, are associated with two volleys of the afferent pathway, thus leading to a rise in baroreflex activity. This premise was confirmed by a previous work (4) where it was demonstrated that the two peaks seen on the aortic waveform, which are caused by left ventricular ejection in systole and balloon inflation in diastole, are associated with two volleys of the afferent pathway, thus leading to a rise in baroreflex activity.…”

supporting

confidence: 76%

Effects of Intra‐Aortic Balloon Pump Timing on Baroreflex Activities in a Closed‐Loop Cardiovascular Hybrid Model

et al. 2012

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Despite 50 years of research to assess the intra-aortic balloon pump (IABP) effects on patients' hemodynamics, some issues related to the effects of this therapy are still not fully understood. One of these issues is the effect of IABP, its inflation timing and duration on peripheral circulation autonomic controls. This work provides a systematic analysis of IABP effects on baroreflex using a cardiovascular hybrid model, which consists of computational and hydraulic submodels. The work also included a baroreflex computational model that was connected to a hydraulic model with a 40-cm(3) balloon. The IABP was operated at different inflation trigger timings (-0.14 to 0.31 s) and inflation durations (0.05-0.45 s), with time of the dicrotic notch being taken as t = 0. Baroreflex-dependent parameters-afferent and efferent pathway activity, heart rate, peripheral resistance, and venous tone-were evaluated at each of the inflation trigger times and durations considered. Balloon early inflation (0.09 s before the dicrotic notch) with inflation duration of 0.25 s generated a maximum net increment of afferent pathway activity of 10%, thus leading to a decrement of efferent sympathetic activity by 15.3% compared with baseline values. These times also resulted in a reduction in peripheral resistance and heart rate by 4 and 4.3% compared with baseline value. We conclude that optimum IABP triggering time results in positive effects on peripheral circulation autonomic controls. Conversely, if the balloon is not properly timed, peripheral resistance and heart rate may even increase, which could lead to detrimental outcomes.

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supporting

confidence: 76%

Effects of Intra‐Aortic Balloon Pump Timing on Baroreflex Activities in a Closed‐Loop Cardiovascular Hybrid Model

et al. 2012

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“…Normann and Kennedy suggested that the presence of two peak pressures in one cardiac cycle might stimulate the arterial baroreceptors (26). In both groups, there was a decrease of the LFpowers of BP mean during EECP.…”

Section: Discussionmentioning

confidence: 87%

Enhanced external counterpulsation does not compromise cerebral autoregulation

Marthol¹,

Werner

Brown³

et al. 2005

Acta Neurol Scand

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“…Although phasic inflation of an intra-aortic balloon has been documented to augment arterial baroreceptor firing during diastole (18); the coronary vascular response to the baroreceptor reflex is controversial. Both coronary vasoconstriction (5) and coronary vasodilation (15) have been reported during acute elevations in carotid sinus pressure.…”

Section: Discussionmentioning

confidence: 99%

Demonstration of coronary artery myogenic vasoconstriction in the awake dog

et al. 1987

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The aim of this study was to determine whether or not coronary vasoconstriction occurs in response to a transient increase in coronary perfusion pressure. Eleven awake dogs with formalin-induced heart block, chronically instrumented with aortic and left ventricular catheters and left circumflex coronary and aortic electromagnetic flowprobes, were studied at a paced heart rate of 60 beats/min. A transient increase in aortic diastolic pressure of 17.3 +/- 1.5% for 330 +/- 20 ms and of 33.6 +/- 2.2% for 520 +/- 20 ms, via the inflation of an intra-aortic balloon, resulted in an increase in diastolic coronary vascular resistance index in the first response beat of 6 +/- 1% and 11 +/- 1%, respectively. An identical increase in diastolic coronary flow produced by the omission of a single paced beat resulted in no significant change in diastolic coronary vascular resistance index in the first response beat. Thus, the increase in diastolic coronary vascular resistance index following diastolic pressure augmentation is related to the increase in aortic diastolic pressure and not to the increase in diastolic coronary flow. These data are consistent with that of a brief myogenic response.

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Arterial baroreceptor responses to intraaortic balloon assistance

Cited by 21 publications

References 12 publications

Effects of Intra‐Aortic Balloon Pump Timing on Baroreflex Activities in a Closed‐Loop Cardiovascular Hybrid Model

Effects of Intra‐Aortic Balloon Pump Timing on Baroreflex Activities in a Closed‐Loop Cardiovascular Hybrid Model

Enhanced external counterpulsation does not compromise cerebral autoregulation

Demonstration of coronary artery myogenic vasoconstriction in the awake dog

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