Arterial baroreflex function is an important determinant of acute cerebral ischemia in rats with middle cerebral artery occlusion

Liu, Aijun; Ling, Gang; Wu, Jian; Shen, Fu‐Ming; Wang, Di-Song; Lin, Lili; Liu, Jianguo; Su, Ding‐Feng

doi:10.1016/j.lfs.2008.06.021

Cited by 19 publications

(25 citation statements)

References 34 publications

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“…Baroreflex dysfunction was significantly associated with increased levels of proinflammatory factors interleukin-1 and interleukin-6 as well as with infarct growth. 25 In line with the latter, an interesting study by Ai et al showed in humans that MCA infarcts encompassing the insula, one of the principal autonomic and baroreflex regulatory areas, are more prone to growth. 26 Second, impaired BRS in acute stroke is associated with blood pressure derangements including hypertensive crises and increased blood pressure variability.…”

Section: Discussionmentioning

confidence: 81%

Baroreflex Sensitivity to Predict Malignant Middle Cerebral Artery Infarction

Sýkora

Steiner

Rocco

et al. 2012

Stroke

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Background and Purpose-Hemicraniectomy has been shown to be an effective treatment of life-threatening edema (LTE) in malignant middle cerebral artery infarction when performed early. Identifying patients who will develop LTE is therefore imperative. We hypothesize that autonomic shift toward sympathetic dominance may relate to LTE formation. We aimed to investigate the predictive potential of baroreflex sensitivity (BRS) as a marker of autonomic balance for calculating the course of large middle cerebral artery infarction. Methods-Patients with middle cerebral artery infarction Ͼ2/3 of the territory and BRS measurement at admission were analyzed. BRS was estimated using the cross-correlational method. Demographic, clinical, and radiological data including stroke severity, infarct size, and basal ganglia involvement were recorded. Malignant course with LTE was defined as clinical deterioration and midline shift Ն5 mm in the first 48 hours. Results-Eighteen

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Section: Discussionmentioning

confidence: 81%

Baroreflex Sensitivity to Predict Malignant Middle Cerebral Artery Infarction

Sýkora

Steiner

Rocco

et al. 2012

Stroke

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“…Baroreflex sensitivity was measured using a previously described method. 14,15 Phenylephrine (5 to 10 mg/kg, intravenously) was used to raise SBP by about 30 mm Hg. The delay between the rise in blood pressure (stimulus) and the prolongation of heart rate (response) was B1 second.…”

Section: Blood Pressure and Baroreflex Sensitivitymentioning

confidence: 99%

“…11,12 Recently, the work in this laboratory suggested that arterial baroreflex dysfunction is an important risk fact for the development of stroke. 14,15 In the current study, we tested the hypothesis that arterial baroreflex is involved in the protective effect of DR against stroke. The interaction of DR, SIRT1, and stroke was also evaluated.…”

Section: Introductionmentioning

confidence: 99%

Involvement of Arterial Baroreflex in the Protective Effect of Dietary Restriction Against Stroke

Liu

Guo

Liu

et al. 2013

J Cereb Blood Flow Metab

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Dietary restriction (DR) protects against neuronal dysfunction and degeneration, and reduces the risk of ischemic stroke. This study examined the role of silent information regulator T1 (SIRT1) and arterial baroreflex in the beneficial effects of DR against stroke, using two distinct stroke models: stroke-prone spontaneously hypertensive rats (SP-SHRs) and Sprague-Dawley (SD) rats with middle cerebral artery occlusion (MCAO). Sirt1 knockout (KO) mice were used to examine the involvement of sirt1. Sinoaortic denervation was used to inactivate arterial baroreflex. Dietary restriction was defined as 40% reduction of dietary intake. Briefly, DR prolonged the life span of SP-SHRs and reduced the infarct size induced by MCAO. Dietary restriction also improved the function arterial baroreflex, decreased the release of proinflammatory cytokines, and reduced end-organ damage. The beneficial effect of DR on stroke was markedly attenuated by blunting arterial baroreflex. Lastly, the infarct area in sirt1 KO mice was significantly larger than in the wild-type mice. However, the beneficial effect of DR against ischemic injury was still apparent in sirt1 KO mice. Accordingly, arterial baroreflex, but not sirt1, is important in the protective effect of DR against stroke.

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“…6 In 1987, WKY from two different laboratories presented differences with respect to growth rate and blood pressure. 10 Although it was previously shown that a portion of normotensive Sprague-Dawley rats spontaneously exhibit lower baroreflex sensitivity 7,11 , no previous study investigated whether differences of baroreflex sensitivity occurred among other type of rats of the same strain. Therefore, in this study we compared the baroreflex sensitivity among young WKY from the same laboratory to determine if there are intra strain differences.…”

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confidence: 99%

Intra-strain variations of baroreflex sensitivity in young Wistar-Kyoto rats

Valenti

Imaizumi²,

Abreu³

et al. 2009

CIM

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Clin Invest Med 2009; 32 (6): E251-E257. AbstractPurpose: To compare baroreflex sensitivity among conscious rats of the same strain. Methods: Male WKY rats (eight weeks old) were studied. Cannulas were inserted into the abdominal aortic artery through the right femoral artery to measure mean arterial pressure (MAP) and heart rate (HR). Baroreflex gain was calculated as the ratio between variation of HR in function of the MAP variation (ΔHR/ΔMAP) tested with a depressor dose of sodium nitroprusside (SNP, 50µg/kg, iv) and with a pressor dose of phenylephrine (PE, 8µg/kg, iv). We divided the rats into four groups: 1) Low bradycardic baroreflex (LB), BG between -1 and -2 bpm/mmHg tested with PE; 2) High bradycardic baroreflex (HB), BG < -2 bpm/mmHg tested with PE; 3) Low tachycardic baroreflex (LT), BG between -1 and -2 bpm/mmHg tested with SNP and; 4) High tachycardic baroreflex (HT), BG < -2 bpm/ mmHg tested with SNP. Significant differences were considered for p<0.05.Results: Approximately 82% of the rats presented reduced bradycardic reflex while 22 showed attenuated tachycardic reflex. No alterations were noted regarding basal MAP and HR, tachycardic and bradycardic peak and HR range. Conclusions: There was alteration in baroreflex sensitivity among rats of the same strain. Care should be taken when interpreting studies employing WKY as a control for the SHR.In 1963, Okamoto and Aoki 1 reported that they had selectively bred Wistar rats to be spontaneously hypertensive. Established as an inbred strain in 1969 at the National Institutes of Health (NIH), the spontaneously hypertensive rat (SHR) remains the most widely studied animal model of essential hypertension (i.e., persistent high blood pressure of unknown causation), and the strain presents similar characteristic to hypertension in humans. As controls for the SHR, most workers have employed normotensive descendants of Wistar rats that NIH investigators obtained in 1971 from the colony in Kyoto from which the SHR strain was originally derived (Wistar-Kyoto rats, WKY). 2 Baroreflex function is one of the body's homeostatic mechanisms to sustain arterial pressure. It offers a negative feedback loop in which the increased arterial pressure reflexively causes blood pressure to de-

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Arterial baroreflex function is an important determinant of acute cerebral ischemia in rats with middle cerebral artery occlusion

Cited by 19 publications

References 34 publications

Baroreflex Sensitivity to Predict Malignant Middle Cerebral Artery Infarction

Baroreflex Sensitivity to Predict Malignant Middle Cerebral Artery Infarction

Involvement of Arterial Baroreflex in the Protective Effect of Dietary Restriction Against Stroke

Intra-strain variations of baroreflex sensitivity in young Wistar-Kyoto rats

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